溶瘤細胞的 的英文怎麼說

中文拼音 [róngliúxìbāode]
溶瘤細胞的 英文
oncolytic
  • 溶 : 動詞（溶化; 溶解） dissolve
  • 瘤 : 名詞（瘤子） tumour
  • 細 : 形容詞1 （條狀物橫剖面小） thin; slender 2 （顆粒小） in small particles; fine 3 （音量小） thin ...
  • 胞 : Ⅰ名詞1 （胞衣） afterbirth2 （同一個國家或民族的人） fellow countryman; compatriot Ⅱ形容詞（同胞...
  • 的 : 4次方是 The fourth power of 2 is direction
  • 細胞 : cell; sytes; bioplast; cella; [口語] gene; [生物學] cellule; cellule cellulli cellulo ; cello ; k...
  1. Effect of gapsgf injection on soluble proteome of hepa carcinoma

    瘤細胞可溶性蛋白質組影響的實驗研究
  2. The characteristics of this method are : a, directly counting cell number without the influence of the metabolic state of the cells ; b, discrimination of target cells from effector cells in cell - mediated cytotoxicity assay ; c, less treatment step, and free - radioactivity ; d, high sensitivity and reliability. 2, using the above assay, immunofluorescent labeled technique, and flow cytometry, the pbmc proliferation, apoptosis, necrosis, cell cycle, activation, cytokines and membrane marker were detected. the results showed that the number of pbmc reduced, but the activity of pbmc increased dose - dependently ; the reduction of cell number resulted from necrosis and apoptosis ; the supernatant of k562 cell lines were not able to block the cell cycle, but to promote it ; the ratio of t cell subset and the expression of thl and th2 cytokines increased

    結合以上創建的方法和免疫熒光流式細胞術，用k562細胞株可溶性分泌物（上清）對外周血單個核細胞（ pbmc ）進行培養以模擬體內微環境，然後分別從細胞增殖、凋亡、壞死、細胞周期、活性、細胞因子和表面抗原表達等方面進行研究，結果發現用腫瘤上清培養的pbmc細胞數量下降明顯，但同時對其有激活作用，且呈劑量依賴性；細胞數的下降主要是由細胞壞死和凋亡引起的，腫瘤上清對細胞周期沒有阻斷作用，反而略有促進作用； t細胞亞群比例增加，並促進表達th1 、 th2細胞因子。
  3. 2 ) basis of upon studies, we have also designed and sythesized the mutation ii of the cmiv that been greatly changed in the 3 " of the gene comparing with nature cmiv : the ht gf3 ( the third loop region of htgf2 specifically binding to egfr receptor ) was fused to 3 " of gene of cmiv through a flexible linker. the gene of the mutation ii of cmiv was sequenced and clonged to the vector of ptxfus to fuse to the 3 " of gene of thioredoxin

    二、在以上研究的基礎上，對cmiv抗菌肽的c端進行較大的改造，即將與腫瘤細胞過度表達的表皮生長因子受體（ egfr ）具有高親和性的因子多肽tgf _ 3通過疏水柔性接頭連接在抗菌肽cmiv的c端，設計完整的基因，並在大腸桿菌中利用ptxfus表達載體與硫氧還蛋白進行可溶性融合蛋白表達。
  4. Unfortunately, tumor cells can secrete immunosuppressor factors ( such as il - 10, tgf - p, vegf ) to interfere with dc maturation and function. to overcome tumor - mediated inhibition of dc maturation and function in vivo, immunopotentiating cytokines ( such as il - 7, il - 12 ) were used for gene - modification of dc, which has proven to be an efficient way to treat cancer in animal models

    雖然有直接瘤內注射dc誘導抗腫瘤免疫效應的報道，但腫瘤局部往往是一個處于高度免疫抑制狀態的微環境，腫瘤細胞分泌的可溶性介質（如ill 、 tgf卜vegf等）能抑制dc的分化成熟，下調dc表面共刺激分子的表達和iliz的分泌，從而抑制dc的抗原提呈功能，亦對t細胞功能有顯著的抑制作用。
  5. The originalities of this paper are : 1, development of a a flow cytometry - based assay for quantitative analysis of cellular proliferation and cytotoxicity in vitro ; 2, the soluble secretion of k. 562 cell lines reduce the number of pbmc, but promote the activity of pbmc in dose - dependent manner ; 3, soluble secretion of k562 cell lines can induce the no production by pbmc, but no only plays a part of the role of soluble secretion of k562 cell lines ; 4, establishing a in vitro model and giving some parameters for sreening and appraising anti - tumor medicine

    本研究的創新點在於： l 、建立了用流式細胞術定量測定細胞增殖和細胞毒性的直接檢測技術； 2發現k562可溶性分泌物劑量依賴性地使pbmc細胞數量減少但活性增加； 3 、 k562可溶性分泌物能誘導pbmc產生no ，但是no的作用並不等同於腫瘤上清的全部作用。 4 、為抗腫瘤藥物篩選提供了一個體外模型，並明確了一些篩選指標。
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