激素核受體 的英文怎麼說
中文拼音 [jīsùhéshòutǐ]
激素核受體
英文
hormone nuclear receptor-
Estrogen through binding specific estrogen department of physiology 7 receptor ( er ) in nucleus, functions like a nucleus transcription factor and modulates expression of some genes. it has been found that there exist two subtypes of er. there are a and p subunits which are different in their distribution, density and mediated action
雌激素調節神經系統功能往往通過雌激素受體( estrogenreceptor , er )蛋白介導。 er屬于類固醇受體超家族的核受體,具a 、 p兩種亞型,此二者在各種組織分佈及密度泅異。Estrogen receptor ( er ), an important transcription factor belonging to the nuclear receptor superfamily, plays a key role in reproductive, cardiovascular and central nervous systems and bone tissue
摘要雌激素受體屬于核受體超家族成員,是一類重要的核轉錄因子,它在生殖系統、骨組織、心血管和中樞神經系統中發揮著重要的生理作用,是治療骨質疏鬆和乳腺癌的重要藥物作用靶標。One is as signal transducers outside of the nucleus, named nongenomic action. the other is as transcription activators in the nucleus, named genomic action. the two ways may coexist, cooperate and coregulate in the development and maturation of oocyte
類固醇激素受體在卵母細胞中可能通過兩種途徑發揮作用,一種是存在於胞質中,作為信號轉導因子的非基因組調控機制;另一種是存在於核中,作為核轉錄活性因於,改變基因轉錄活動的基因組調控機制。In addition to the classical genomic pathway through nucleus receptors, estrogen can cause to produce some cellular rapid membrane - mediated effects through nongenomic pathway
Er具核、膜雙重分佈特徵。雌激素的作用通過經典的核受體通路和膜受體通路來完成。There are a and 3 subunits of estrogen receptor ( er ) subtypes. they are different in their distribution, density and mediated action. er can be expressed in nucleus or in cellular membrane
雌激素受體( er )屬于類固醇受體超家族的核受體,具有a和日兩種亞型,此二者在各種組織分佈及密度各異。The following research areas will be involved in the project : ( 1 ) mechanism of hereditic factors and its function in chinese type 2 diabetes ; ( 2 ) metabolomics on the cell stress and its nutrition intervention in the type 2 diabetes ; ( 3 ) mechanisms of metabolic nuclear receptors in the process of insulin resistance and type 2 diabetes onset ; ( 4 ) roles of signal transduction molecules, lipid metabolic disorder to insulin resistance ; ( 5 ) type 2 diabetes development and role of pathological changes of blood vessels ; ( 6 ) abnormal insulin secretion, apoptosis and type 2 diabetes ; ( 7 ) function of molecular network of type 2 diabetes progression
本項目擬開展以下研究工作: ( 1 )中國人2型糖尿病發生過程中遺傳因素的發現及其作用機制; ( 2 )細胞應激在中國人2型糖尿病發生過程中的作用機制及其營養干預的代謝組學; ( 3 )代謝性核受體在胰島素抵抗和2型糖尿病發病中的作用機制; ( 4 )細胞信號轉導分子、脂代謝紊亂與胰島素抵抗的關系; ( 5 ) 2型糖尿病發展過程與血管病變; ( 6 )胰島素分泌異常、細胞凋亡與2型糖尿病; ( 7 ) 2型糖尿病發生過程中的分子網路與作用機制。The colocalization results implicated that nk3 and vasopressin ( vp ) are in same neurons. and by regulating expressing and releasing of vp, nig can modulate function of the paraventricular nucleus and superoptic nuclei. especially it is closely related to salt and water taste
在室旁核和視上核存在nk3受體與加壓素的雙標神經元,與水鹽代謝有關的神經元在高滲刺激下表達fos ,同時可以激活含nk3受體神經元,提示nk3受體通過調節加壓素釋放參與水鹽代謝和滲透壓的調節。Its gene includes seven exons ( 3 - 9 ) and six introns ( 3 - 8 ). with respect to zfghrl, it is also like other ghr1s, which consists of 1578bp and encode a 528 amino acid protein. its gene only includes eight exons ( 1 - 5, 8 ) and seven introns ( l - 5 ). various methods used to find out the transmembrane and boxl domain of zfghrl but the result turns out to be fruitless due to unknown reason. fghr2 and zfghr2 : fghr2 includes eight exons and seven introns, which consists of 1710 bp and encodes a 569 amino acid protein ; zfghr2 includes eight exons ( 1 - 5, 8 ) and seven introns ( 1 - 5 ), which consists of 1758 bp and encodes a 484 amino acid protein
得到的fghr1含有7個外顯子( 3 - 9 )和6個內含子( 3 - 8 ) ,由1755個bp的核苷酸組成並編碼一個584個氨基酸殘基的蛋白質:得到的zfghr1包含有1587個核苷酸並編碼一個528個氨基酸殘基的蛋白質,理學碩士學位論文:南方貼生長激素受體cdna的分子克隆和魚類存在兩種生長激素受體的證明其基因只有8個外顯子( l一5 , 8 )和7個內含子( 1一5 ) 。分享友人