肽模擬學 的英文怎麼說
中文拼音 [tàimónǐxué]
肽模擬學
英文
peptide mimeties- 肽 : 名詞[化學] （有機化合物） peptide
- 模 : 模名詞1. （模子） mould; pattern; matrix 2. （姓氏） a surname
- 擬 : 動詞1. （設計; 起草） draw up; draft 2. （打算; 想要） intend; plan 3. （模仿） imitate
- 學 : Ⅰ動詞1 （學習） study; learn 2 （模仿） imitate; mimic Ⅱ名詞1 （學問） learning; knowledge 2 （學...
- 模擬 : imitate; simulate; analog; analogy; imitation; simulation模擬艙 boilerplate; 模擬電路 [電學] circ...
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It was found that in the simulated physiological solution, the hydrogen bindings between some amido groups in the mp - 11 molecules are decomposed and the mp - 11 dimers become monomers. it induces the increase in the contents of the a - helical and ( 3 - turn conformation, the decrease in the content of the random coil conformation of mp - 11 as well as the increase in the exposure extent of the heme group. therefore, the reversibility of the electrochemical reaction and the electrocatalytic activity of mp - 11 for h2o2 reduction increase comparing the situation in the aqueous solution
發現在模擬生理條件下， mp - 11分子的多肽鏈上一些酰氨基的氫鍵發生了解離，使部分雙聚的mp - 11分子變成單體分子， mp - 11分子二級結構中-螺旋和-轉角結構的含量增加，無規捲曲結構含量降低，導致了mp - 11分子中血紅素的暴露程度變大，因此mp - 11電化學反應的可逆性和對h _ 2o _ 2還原的電催化活性比在水溶液中有所增加。Part ii screening of tnfa mimotopes from phage display peptide library : based on the results of screening tnfa binding - peptides, we have tried to use neutral tnfa mcab j1d9 as target to screen tnfa mimotopes from c7c phage display peptide library, which may be another form of antagonist for tnfa, and the mimotopes were identified by sandwich elisa. after 3 rounds of screening, we got 9 phage clones identified as positive clones which can bind with mcab j1d9. we also identified the binding between mimotopes and tnf receptor by competitive elisa, and the results showed strongly binding. the amino acid sequence results shown three different sequences : c - rrpaqsg - c - nkhnrki - c and c - rgmsrki - c
在對噬菌體環七肽庫進行三輪親和性篩選后，隨機挑選20個噬菌體克隆， elisa鑒定出9個陽性克隆，經dna測序推出三種氨基酸序列： c - rrpaqsg - c 、 c - nkhnrki - c和c - rgmsrki - c ，其中優勢克隆序列為c - rrpaqsg - c ；鑒定結果顯示陽性克隆能夠與tnf受體結合，並且能夠阻斷tnf與受體的結合，提示篩選得到的環七肽克隆展示肽具有tnf的抗原性及與tnf受體結第一軍醫大學顧士學位論文合的特性，為tnfa表位模擬肽。
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