胰腺纖維變性 的英文怎麼說
中文拼音 [yíxiànxiānwéibiànxìng]
胰腺纖維變性
英文
fibrosis of pancreas-
Gall-bladder disease and cystic fibrosis also often involve me.
膽囊疾病和胰腺囊性纖維性變也常常糾纏我。Cystic fibrosis is caused by mutations in the gene encoding an ion - transport protein, the cystic - fibrosis transmembrane conductance regulator ( cftr ). defective secretion of anions is the primary cause of many of the clinical manifestations of cystic fibrosis, including pancreatic insufficiency
囊性纖維化是由作為陰離子通道的跨膜電導調節器（ cftr ）的基因突變所致，而陰離子分泌缺損是囊性纖維化的多種臨床表現（包括胰腺功能缺陷）的主要原因。The newly identified gene, nyd - sp27 has structural similarity to an isoform of phospholipase c. nyd - sp27 was expressed endogenously in human pancreatic - duct cells and upregulated in cystic fibrosis. researchers has proved that suppression of the gene resulted in augmentation of phospholipase - c - coupled calcium - ion release and protein kinase c activity, improvement in the amount of mutated cftr reaching the plasma membrane, and thus restoration of pancreatic anion secretion
Nyd - sp27內源性表達在人體的胰腺導管上皮細胞，並在囊性纖維化時表達增高，顯示該基因可能與病變有關。研究人員發現通過抑制該基因在人體囊性纖維化胰腺導管細胞中的表達，可以糾正缺陷的胰腺陰離子分泌。
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