阻抑基因 的英文怎麼說
中文拼音 [zǔyìjīyīn]
阻抑基因
英文
repressor gene-
In 2005, researchers at sloan - kettering reported that the gene could stop massie tumor growth in prostate cancer een when another tumor suppressor, known as p53, was turned off
早在2005年，斯隆-凱特琳中心的研究人員就曾報道了在另一種叫做p53的腫瘤抑制基因關閉時，該基因甚至仍然可以阻止前列腺癌大腫瘤生長。The seven sisters that dr de grey wishes to slaughter with sens are cell loss, apoptosis - resistance ( the tendency of cells to refuse to die when they are supposed to ), gene mutations in the cell nucleus, gene mutations in the mitochondria ( the cell ' s power - packs ), the accumulation of junk inside cells, the accumulation of junk outside cells and the accumulation of inappropriate chemical links in the material that supports cells
德?戈瑞博士想用這一策略對付的七個因素是：細胞丟失，細胞凋亡阻抑（細胞拒絕程序死亡的傾向） ，細胞核內的基因突變，線粒體（細胞的「動力倉」 ）中的基因突變，細胞內的垃圾堆積，細胞外的垃圾堆積和細胞支持性物質中不當化學鍵堆積。Deficiency of apoe may promote to produce and develop atherosclerotic lessions. the apoe gene - targeted mice will result in marked regression of both early and advanced atherosclerotic lesions by injected apoe recombinant protein, or by transfected adviral vector with apoe cdna to express human apoe transgene in liver, or by transplantation of bone marrow with normal rat apoe gene. this demonstrates that apoe gene and its expressing product can inhibit progression of atherogenesis. apoe3 has a more effective prevention from as than apoe2 and apoe4
Apoe的缺失可促進動脈粥樣硬化的發生發展，給apoe基因敲除鼠反復注射apoe重組蛋白、在肝組織中用腺病毒載體表達apoe蛋白、移植帶有正常apoe基因的小鼠骨髓，都能使apoe基因敲除鼠的動脈粥樣硬化得到回復，表明apoe基因及其表達產物對動脈粥樣硬化的發生具有抑制作用， apoe _ 3對動脈硬化的阻抑作用要比apoe _ 2和apoe _ 4都明顯。A c a2 + / calmo dul in - dep endent pro te in kinas e i i ( c amkii ) antagoni st kn - 6 2 ( 5x l0 - ' mol / l ) presented in the intemal solution had no significan effect on the current peaks induced by extracellular nmda ( l0 # mol / l ), but prevented the inhibitory effect of b on inmda " these results indicate that gcs have rapid, reversible idebitory effects on lnmda intracellular application of b thiough microelectrode had no effect on inmda, howevet, extracellular application of b or b - bsa suppressed peaks of inmda : all these denote b exerts its influence on nmda receptor by cytoplasm membrane mechansms, which is naxnely rapid, nongenomic mechhasms
加有快速、可逆的。非濃度依賴性抑制作用。通過微電極將b直接導入細胞內， inmda不受影響，而胞外給予b或besa ， inmda減小，提示b對nmda受體的調控通過膜機制產生，這種作用與經典的基因組機制不同；因為廣譜激酶抑制劑和特異的pka抑制劑均可翻轉b的抑制效應， camk11抑制劑也可阻斷b的效應，而這些激酶抑制劑本身對inmda即有強烈的抑制作用： pka激動劑本身對inmda無明顯作用，也不影響b對l 。Restin was a novel gene isolated by our lab from differentiation tumor cell induced by all - trans retinoic acid in 1999, and its molecular functions were not well understood. it mainly expresses in terminally differentiated cells. by transfection of restin into tumor cell, the cells were arrested in g1 phase and the cell proliferation was inhibited
Restin是1999年本室在研究全反式維甲酸誘導細胞分化時克隆得到的一個人類未知功能的新基因，該基因主要表達于終末分化細胞，穩定轉染該基因的細胞出現g1期阻滯，抑制細胞的增殖，提示restin與細胞周期的調控有關。This silencing also affects the function of many tumor suppressor genes, which, in their unmethylated state, put the brakes on uncontrolled cell growth
這種沉默也影響許多抑癌基因的功能，這些基因在非甲基化狀態下可以阻止不受控制的細胞生長。Tumor - suppressor genes normally protect cells from becoming cancerous, but the gradual silencing of these genes by abnormal methylation is thought to be an early change in cancer deelopment
抑癌基因通常是阻止細胞腫瘤化，隨著這些基因不正常的甲基化，他們就開始沉默，這被視為腫瘤的早期改變。Doc - 1r gene is an candidate tumor suppressor gene which was discovered by zhangxue. it can interact with cdk2 specifically and restrain cdk2 transportation into the nucleus, which will block the formation of cdk2 and cyclin complex and hinder the process of cell cycle
Doc - 1r基因是張學等發現的一個候選抑癌基因，它可與cdk2特異性結合，抑制cdk2的入核轉運，使cdk2不能與cyclin形成復合物，從而阻抑細胞周期的進程。An expression vector with fragment 9 in antisense orientation was constructed to block the expression of the relevant gene ( fragment 9 related gene, fnr gene ) in vero cells. interestingly, we found that the nontargeted mutation frequency induced by mnng was increased significantly, implicating that the product of the blocked gene may be involved in the inhibition of nontargeted mutation
利用反義核酸技術構建含反向插入9號片段的真核細胞表達重組體並轉染細胞，以獲得反義rna阻斷vero細胞中相應基因的表達，發現mn 』 ng誘發的非定標性突變頻率顯著增高，提示被阻斷的相關基因的表達產物可能參與抑制非定標性突變的發生。Abstract : since piezoelectric resonant filter can not effectively prohibit higher - frequency harmonic, the mechanism of this problem has been discussed by means of a specific example which shows that there exists lots of undesirable resonant frequencies of piezoelectric that would let pass undesirable signals. to solve this problem ， an ameliorated electrostatic mechanical resonant filter is proposed and a specific case is demonstrated. the example of electrostatic resonant micro - bridge asserts that by adjusting the gap of exciting capacitance the higher - frequency vibrating model of micro - bridge cannot be excited based on orthogonal character of intrinsic vibrating shape of micro - bridge, so that this kind of resonant filter can effectively filter out undesirable higher - frequency harmonic
文摘:提出壓電諧振濾波器不能很好地濾除高頻諧波的問題，結合一個具體例子理論推導了壓電諧振濾波器存在許多干擾諧振頻率，從而不能有效濾除一些特定頻率的干擾信號.為了解決這個問題，提出一種改進型的靜電激勵諧振濾波器.為了說明其可行性，具體分析了改進型雙端固支微梁靜電激勵諧振濾波器，理論推導證實基於雙端固支微梁的各階振型正交的原理，通過適當調整激振電容的間距，雙端固支微梁的高階振動模態受到很好的抑制，因此這種諧振濾波器可以有效阻止濾波器中心頻率的高頻諧波的通過Since piezoelectric resonant filter can not effectively prohibit higher - frequency harmonic, the mechanism of this problem has been discussed by means of a specific example which shows that there exists lots of undesirable resonant frequencies of piezoelectric that would let pass undesirable signals. to solve this problem ， an ameliorated electrostatic mechanical resonant filter is proposed and a specific case is demonstrated. the example of electrostatic resonant micro - bridge asserts that by adjusting the gap of exciting capacitance the higher - frequency vibrating model of micro - bridge cannot be excited based on orthogonal character of intrinsic vibrating shape of micro - bridge, so that this kind of resonant filter can effectively filter out undesirable higher - frequency harmonic
提出壓電諧振濾波器不能很好地濾除高頻諧波的問題，結合一個具體例子理論推導了壓電諧振濾波器存在許多干擾諧振頻率，從而不能有效濾除一些特定頻率的干擾信號.為了解決這個問題，提出一種改進型的靜電激勵諧振濾波器.為了說明其可行性，具體分析了改進型雙端固支微梁靜電激勵諧振濾波器，理論推導證實基於雙端固支微梁的各階振型正交的原理，通過適當調整激振電容的間距，雙端固支微梁的高階振動模態受到很好的抑制，因此這種諧振濾波器可以有效阻止濾波器中心頻率的高頻諧波的通過We concluded that excessive expression of exogenous htr gene may compete with the endogenous telomerase rna and prevent rna template from combining with telomeric dna, thus repressing the elongation of telomeric dna ( telomeres ) and causing cell aging and cell death. - 6 - 3. some modifications have been made to overcome the limitation of conventional telomeric repeat amplification protocol ( trap ) assay
分析其原因，可能是htr基因的過表達在數量和空間效應上同細胞內的端粒酶rna組分產生竟爭，一定程度上阻礙了端粒酶rna模板區與端粒dna的結合，從而抑制端粒dna的延伸，導致細胞凋亡。Objective the aim of this article was to induce long term survival allografts by blocking cd40 - cd40l pathway with homemade anti - cd40l monoclonal antibody mr1, then purify cd4 + cd25 + regulatory t cells from recipients with long term survival allografts, and adoptively cotransfer such cells together with tcr transgenic allogenic antigen specific cd8 + t cells into immunodeffient mouse. finally study whether cd4 + cd25 + t cells can suppress allogenic antigen specific cd8 + t cell mediated rejection, thus clarified whether cd4 + cd25 + t cell mediated regulation is one of mechanisms of prolongation of allograft survival by cd40 - - cd40l pathway blockade
從移植物長期存活的受體內分選出cd4 + cd25 + t細胞，與tcr轉基因cds + t細胞同時過繼輸注到免疫缺陷小鼠體內，觀察co4 + co25 + t細胞對同種異體反應性cos + t細胞介導排斥反應的作用，探討在阻斷cd40se一~ cd40l共刺激途徑延長移植物存活中， cd4 + cd25 +調節性丁細胞是否是抑制排斥反應的機制之一。分享友人