activation signals 中文意思是什麼
-
Changes of intracellular calcium regulatory signals in pc12 cells during the activation and desensitization induced by anatoxin - a
12細胞激活和脫敏時胞內鈣調信號的變化 -
Dendritic cells ( dc ) is the most powerful apc, which can markedly increase the antigen - presentation capacity by maximizing the pepitide - mhc complexes on the cell surface and upregulating the co - stimulatory ligands b7 - 1 and b7 - 2, adhesion moleculees such as il - 12 that promote full activation of lymphocytes. full activation of antigen - specific t cells requires two signals - one signal coming via the tcr and the other signal through engagment of co - stimulatary molecules. t cells receiving one signal via their tcr are turned off by mhc ( major histocompatibility complex ), via t cell cd28 binding to b7 on the dc induce tlymphokine and t cell proliferatiion
T細胞介導的細胞免疫在控制腫瘤生長方面發揮著重要作用， t細胞在發揮抗瘤效應（分泌細胞因子和直接殺傷）之前必須先經過活化，體內專職抗原提呈細胞（ apc ）細胞並使其活化，樹突狀細胞（ dendriticcell ， dc ）為t細胞的激活提供雙重信號， t細胞藉助tcr識別由dcmhc分子遞交的抗原肽后，通過tcr - cd3復合體傳遞抗原特異性識別信號（第一信號） ，以cd28為主的t細胞表面輔佐分子識別dc表面b7分子，傳遞非特異性協同刺激信號（第二信號） ，在機體抗腫瘤免疫應答中處于核心地位。 -
Bottom - up processing and feature detecting theory based on strong electrophysiological evidences has played a dominant role in the visual research for long time. people know top - down processing just by common sense. knowledge or experience are recalled from memory by reactivation of their neural representations and affected visual processes. however recently, researches from human and monkey provide experimental evidences for top - down processing. first, mnemonic representation of visual objects and faces, located in the ventral processing stream of visual perception in monkey, provide the best evidences of how neuronal codes are created by neurons that have the special ability to link the representations of temporally associated stimuli ; second, experiments suggest that not only bottom - up signals from the retina but also top - down signals from the prefrontal cortex can trigger the retrieval of associative codes, which may serve as a neural basis both for the conscious recall and for the visual processes affected by top - down processing further studies will improve people s understanding of the causal relation of activation and behavior by use of combined fmri and electrophysiology or lesion studies
聯想性編碼是通過學習由一些具有特殊功能的神經元建立的，這些神經元具有將時間性關聯刺激的表徵聯系起來的能力。其次，不僅來自視網膜的底-頂信號，而且來自前額葉的頂底信號都能觸發聯想性編碼的提取，既可以作為有意識回憶的神經基礎，又是頂-底加工影響視覺過程的基礎。腦損傷病人研究具有高時間解析度的人類功能性核磁共振成像functional magnetic resonance imaging ， fmri和猴fmri研究以及猴細胞電生理分析相結合，將進一步加強人們對視覺腦機制的全面理解。 -
This kind of mutation may be not only being triggered by the signals originated from dna damage, but also by the signals of extra - nuclear origin through the epigenetic pathway including the activation of various signal transduction pathways and alterations of gene expressions
這種突變除了可能由dna損傷觸發的途徑外，已證明還有非核起源的信號觸發的外遺傳（ epigenetic ）途徑介入，激活細胞信號轉導通路，引起一系列基因表達的改變而最終導致突變的形成。
分享友人