associated antagonists 中文意思是什麼
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Therefore, blys, its receptor or related antagonists may find medical utility in the treatment of b cell disorders associated with autoimmunity, neoplasia, or immunodeficiency syndromes. in this study, epo signal peptide sequence and hsblys gene were linked by soe method. the fusion product was cloned into eukaryotic plasmids. pcdna3, pcdna3. 1, pefneo, respectively. meanwhile, the epo signal peptide sequence was mutated so as to form a restriction enzyme cut site : bin i. thus the recombinant plasmid can be used as secreting plasmid expressing other gene
本實驗通過3 』端互補，進行引物延伸合成epo信號肽序列：信號肽和hsblys基因採用重疊延伸拼接法形成融合基因；融合基因分別插入pcdna3 . 0 、 pcdna3 . 1 、 pefneo真核載體：引物延伸合成信號肽時，利用亮氨酸同義密碼，將信號肽基因的倒數第二個密碼突變，在重組載體上的信號肽序列之後，形成bln酶切位點，使三種載體成為分泌表達載體。 -
Excitotoxicity, associated with stroke and neurodegeneration, is triggered primarily by massive ca2 + influx arising from overactivation of glutamate receptor channels of the n - methyl - d - aspartate ( nmda ) subtype. although approaches to treatment of these disorders with antagonists of nmda receptor ( nr ) have been testified to be effective in animal models, successful therapy in humans was limited by the severe side effects of complete nr blockade for their space window and time window
已有的nr受體拮抗劑或阻斷劑均為人工合成的小分子藥物，能彌散通過血腦屏障（空間窗過大） ，作用選擇性低，病變腦區及非病變腦區都會受到影響，而且由於神經元可逆性損害的「時間窗」極短，人們難以適時使用有效的神經保護藥物，這些均導致已有的藥物難以進入臨床。
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