autophagosome 中文意思是什麼
autophagosome
解釋
胞噬體-
It is known that cells display the abnormal response of autophagy in undergoing the stress, apoptosis, cell death and many diseases. two forms of rat microtubule - associated protein 1 light chain 3 ( mapllc3 ) exist and serve as a subunit of the microtubule - associated protein 1 and an essential constituent of autophagosome membranes, respectively
已經在細胞的脅迫反應，細胞的凋亡和死亡以及很多疾病組織中都發現了自噬囊泡異常的現象，大鼠微管相關蛋白輕鏈3 （ mapllc3 ）蛋白是第一個在哺乳動物細胞中鑒定的定位在自噬體膜上的蛋白。 -
Two forms of rat microtubule - associated proteinl light chain 3 ( mapllc3 ) exist and serve as a subunit of the microtubule - associated protein 1 and an essential constituent of autophagosome membranes, respectively
大鼠微管相關蛋白輕鏈3 （ map1lc3 ）蛋白在體內同時以兩種不同分子量的形式存在。 -
Subcellular localization by cell fractionation, immunofluorescence revealed that three human isoforms were associated with membranes involved in the autophagic pathway. the glycine and lysine respectively decided the location of autophagosome of human map1lc3a and map1lc3b. in addition, our results indicated that other proteins were involved in the post tranlational modification of human map1lc3b and this modication could be induced by amino acid starvation
人lc3a的膜定位與gly120位點的切割和修飾緊密相關，而人lc3b的膜定位是與lys122相關，進一步證明了修飾方式的特異性，對人lc3b的進一步研究表明參與其修飾的分子也與其它基因不同，並且饑餓可以誘導其修飾的發生。
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