collagen type i 中文意思是什麼

collagen type i 解釋
膠原Ⅰ型
  • collagen : n. 【生物化學】（骨）膠原，成膠質。adj. -ic
  • type : n 1 型，類型，（工業產品的）品種；風格，型式。2 典型，榜樣，樣本，樣板，模範，範本；典型人物；具...
  • i : pron （pl we ） 〈人稱代詞，第一人稱，單數，主格。 （poss adj my; obj me; poss pro mine ） 〉我。...
  1. Results the major morphologic changes were as follows : histologically, alveolar inflammation and interstitial fibrosis were observed. electron microscopic findings were : 1. alveolar type i cells were degenerated 、 broken - down and desquamated, endothelial cells were swelled, with inter cellular tight junction shortened, alveolar type ii cells hyperplastic, basement membrane thinned and deformed ; 2. alveolar macrophages and interstitial macrophages were hyperplastic ; 3. mast cells were infiltrated and degranulated ; 4. electron - dense deposits were present at alveolar wall ; 5. myofibroblasts 、 fibroblasts 、 collagen and basement membrane like material were hyperplastic

    電鏡觀察可見： （ 1 ） i型肺泡上皮細胞變性、崩解和脫落，內皮細胞腫脹，細胞間緊密連接短小， ii型肺泡上皮細胞增生，基底膜變薄和破壞； （ 2 ）肺泡巨噬細胞、間質巨噬細胞增多； （ 3 ）肥大細胞浸潤並見脫顆粒現象； （ 4 ）肺泡壁電子緻密物沉積； （ 5 ）肌纖維母細胞、纖維母細胞、膠原原纖維及基底膜樣物質增生。
  2. There was no difference in other biologic characteristic of mscs between the two separation method, such as cell anchorage ratio and clone formation ratio. ( 2 ) plga film presented uniformity frame with no protuberance and fissure under scanning electron microscopy ( sem ). big aperture with smooth wall and average 400 m i n size running - through each other was observed in porous plga substrate, around the big aperture there were many round micropores about 5 m size. all of the structure were equal and uniform, which satisfied the further research work. ( 3 ) mscs adhesion at earlier time was promoted by biotiegenrafter 3h, cell number was ( 1. 5 0. 18 ) 105 in the plga film coated with biotiegen group, which was significantly higher than that in plga film group ( p < 0. 01 ) and higher than that in coverslip group ( p < 0. 05 ), which cell number was ( 1. 04 0. 21 ) 105. after 6h and 12h biotiegen could not promote cell adhesion, and cell proliferation and alkaline phosphatase ( alp ) activity were not promoted dramatically during 9 days. ( 4 ) cell adhesion was promoted by fibronectin or collagen type i

    G ） i型膠原、纖維粘連蛋白促進細胞增殖，細胞接種后3 、 6 、 gd三個檢測時間點，實驗組細胞均明顯高於對照組。與1型膠原相比，纖維粘連蛋白刺激作用更強。 ） i型膠原、纖維粘連蛋白尚能誘導mscs細胞向成骨細胞分化，不僅表達成骨細胞標志物ocn 、 alp 、 opnmrna ，而且堿性磷酸酶活性明顯增高，堿性磷酸酶及鈣結節7第四軍醫大學博士學位論文一染色均強陽性， i型膠原組mscs細胞堿性磷酸酶活性較fn組更高，有顯著性差異；同時，兔疫組化染色表明，經纖維粘連蛋白作用的mscs1型膠原表達陽性。
  3. It has been confirmed that np30 has sensitizing effect on formation of hepatic egg granulomas in mouse model for hepatic egg granuloma of schistosoma japonicum ; immunization with np30 in kunming mice, c57bl / 6 mice and goats obtained worm reduction of 50. 46 %, 41. 67 % and 42. 78 %, respectively. np30 possesses effects of both anti - fecundity and anti - embryonation immunity on female worms of s. japonicum. moreover, np30 plays a significant down - modulatory role to hepatic granuloma and fibrosis ( the diameter, area and volume of egg granuloma were all significantly less than those of control ; the contents of type i, iii of collagen and fibronectin were also significantly less than those of control )

    已對np30分子進行了較為廣泛的研究，應用小鼠日本血吸蟲肝肉芽腫模型證實np30對蟲卵肉芽腫的形成具有致敏作用；對感染宿主（昆明種小鼠、 c57bl / 6小鼠和山羊）具有較好的免疫保護作用（減蟲率分別為50 . 46 、 41 . 67和42 . 78 ） ；用np30主動免疫小鼠具有抗雌蟲生殖產卵和抗卵胚發育的雙重功效；另外，還對血吸蟲病肉芽腫和肝纖維化有明顯的負調節作用（蟲卵肉芽腫的直徑、面積和體積均明顯小於對照組，肝組織、型膠原及纖維連接蛋白含量均低於對照組） 。
  4. Cell adhesion to surface of the substrate is essential to development of the anchorage - dependent cells. only after adhering to surface followed by spreading can cells develop and proliferate. most synthetic polymers used as orthopaedic matrix substitute present hydrophobicity, which may correlates to the low degree of cell attachment. modification with cell adhesion protein / peptides can be benificial to the cell adhesion on polymers and then affect the cell proliferation and differentiation. cell attachment to substrate is primarily mediated by integrins, a widely expressed family of heterodimeric surface receptors. most extrcellular matrix proteins such as fibronectin, osteopontin, collagen type i, bone sialoprotein and vitronectin contain an arg - gly - asp ( rgd ) sequence which is specific to the fixation of cell membrane receptors like integrin. the main aim of this research is to measure, assess adhesion, proliferation of rabbit marrow stromal cells ( mscs ) on the polymers coated by fibronectin, collagen type i or biotie gen, which includes : ( 1 ) biologic characteristics of rabbit mscs were observed by two types of separating method in primary culture. ( 2 ) adhesion, proliferation and differentiation of mscs cultured on polymers coated with biotiegen were assessed. ( 3 ) also, adhesion, proliferation and differentiation of mscs were assessed on plga film or porous plga substrates coated with fibronectin, or collagen type i respectively. ( 4 ) bone formation was observed on the porous plga substrates coated with collagen type i in vivo. this research aims to give new way to make novel synthetic bone with cell adhesion and high bone induction capabilities

    因此將這些蛋白包被、固定到材料表面，觀察骨組織工程種子細胞mscs細胞的粘附、生長特性是本研究的中心環節，並從以下方面進行探討： （ 1 ）採用不同原代細胞分離方法，研究其對mscs細胞的生物學特性影響。 （ 2 ）檢測基因勝肽膠對mscs細胞粘附、增殖及分化的影響。 （ 3 ）分別採用型膠原及纖維粘連蛋白（ fibronectin ， fn ）包被聚乙醇酸-乳酸共聚物（ poly （ 1actide - co - glycolide ） ， plga ）膜及多孔塊型plga材料，觀察細胞在單層或三維培養狀態下，型膠原及fn對mscs細胞粘附、增殖及向成骨細胞分化效應及能力。
  5. Methods the 54th generation of transformed human embryonic tendon cells and artificial composite materials of carbon fibers ( cf ) and polyglycolic ( pga ) were co - cultured in vitro to construct tet. lt was frozen in liquid nitrogen with four kinds of cpa for 2 months. post - thawed quickly and transplanted into hind limbs of nude mice, and repaired the defects of achilles tendon. after 2, 4, 6, 8, 12 weeks, the morphological, histological, ultrastructure, short tandem repeat loci and immunohistochemistry examination were detected, and biomechanical strength of tet were examined. result tendon cell survived and could secret type i collagen after 12 weeks to transplanted into nude mice. in the group of dmso + raffmose + kh2o4, vacuole in mitochondrion degraded i tendon cell ranged in order, abundant collagen fibers were found and linked each other and the biomechanical strength was increased as time elapsed. c onclusion dmso + raffmose + kh2o4 could protect tet in deep low temperature

    組織工程肌腱制備完成後在四種抗凍劑保護下液氮凍存2月；快速復溫后植入裸鼠以修復跟腱缺損， 2 、 4 、 6 、 8 、 12周后取出，觀察形態學、組織學、電鏡和免疫組織化學變化，短串聯重復位點檢測和生物力學變化。結果實驗組組織工程肌腱體內植入12周后仍有肌腱細胞存活並分泌型膠原；隨著時間延長， 10二甲基亞碸（ dmso ） +棉子糖（ 30mmol l ） + kh _ 2po _ 4 （ 25mmol l ）組線粒體空泡減少，肌腱細胞排列整齊，膠原纖維增粗並連接，抗拉強度增高。
  6. Cell adhesion dramatically increased after 6h by fibronectin and after 12h by collagen type i in monolayer culture

    1型細胞為多角形或長校形， actin表達較少並相對聚集； 11型細胞細胞圓形，鋪展良好， 。
  7. The adsorption and self - assembly of collagen solutions ( type i, from calf skin ) on the mica surface were studied by afm. the mica surface was dealt with mg2 +

    利用afm技術研究來自小牛皮膚的型膠原蛋白溶液在用鎂離子處理過的雲母表面的吸附和自組裝行為。
  8. Pga, phb meshes were dipped into cross - linked type i collagen solution, dried under vacuum freeze condition in a special annular model. the tubular porous scaffolds have elasticity, tenacity and hydrophilic, can maintain their shapes in culture medium for long time

    3cm ，放置培養液中10d ，可保持管腔形狀，不塌陷，不變形，表明採用pga膠原直接模具成型所形成的管形支架是一種較理想的支架材料。
  9. Using those techniques, it is possible to reconstruct vascular model in vitro whose structure and function are same as autogenous vessels. in this experiment two degradable materials were precoated with cross - linked type i collagen, moulded into tubular porous scaffold, and then seeded with ecs. using rotary cell culture technique, vascular model was constructed in vitro

    本實驗採用膠原與幾種可降解材料相復合，構成管形支架，在體外環境下，探索構建分別含內皮細胞、平滑肌細胞及成纖維細胞的三層結構的組織工程化血管，三種細胞相互作用、相互支持，形成一個在形態和功能與正常血管近似的組織工程化血管。
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