costimulation 中文意思是什麼
costimulation
解釋
共同刺激-
Effective activation of antigen - specific t cells not only requires the first signal transduction through t - cell receptor ( tcr ) binding with peptide - mhc complex on the antigen presenting cell ( apc ), but also needs the second signal, termed costimulation. costimulation critical to the degree and consequence of t cell activation is provided by interaction between soluble factors or cell - surface molecules on the t cell and on the apc
而t細胞的活化除需要t細胞受體（ tcr ）與抗原呈遞細胞（ antigenpresentingcell ， apc ）表面的抗原肽- mhc復合物結合所形成的第一信號外，還需要t細胞和apc表面的其它膜分子結合所提供的共刺激信號（亦稱第二信號或輔助刺激信號， costimulatorysignal ）的參與。 -
It has been demonstrated that b7 - cd28 pathway is a prominent costimulation pathway which leads full t cell activation, induces differentiation and regulates the production of cytokines. lacking and blocking of b7 - cd28 pathway will result in blockage of the t cell activation and proliferation
研究表明b7 - cd28通路是最主要的刺激t細胞活化的共刺激信號通路，其不僅參與t細胞活化過程，還影響活化后t細胞的分化、細胞因子產生等。 -
Influence of blockade of cd86 costimulation on th1 th2 cytokines transcription at materno - fetal interface and outcomes of pregnancy
2型細胞因子轉錄調控及妊娠結局的影響 -
Effect of cd86 costimulation on the modulation of th1 th2 cytokines expression at maternal - fetal interface
2型細胞因子表達調控中的作用
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