cyclin 中文意思是什麼

cyclin 解釋
細胞周期調節蛋白,細胞周期蛋白
  1. As the cyclin dependent kinase, cdc2 may act at multiple levels during mitosis to repress ribosome biogenesis, which lead the biosynthesis to a relative silent phase, when the most of cell ' s energy expenditure is used in chromosome condensation, breakdown of the nuclear envelope, and formation of the mitotic spindle

    作為cyclin依賴激酶， cdc2的激酶活性在很大程度上抑制了細胞的合成代謝，使細胞的蛋白合成進入了一個相對的靜止期，而細胞主要的能量則被應用於細胞分裂時的染色體的濃縮、核膜的降解、紡錘體的形成等。
  2. Sds - page and western blotting of plasmodia of physarum polycephalum showed that cyclin b was present in the plasmodia of s phase, g2 phase, prophase, and metaphase. the molecular weight of cyclin b in physarum polycephalum was around 62kda. cyclin b was gradually accumulated from s phase to metaphase, and reached the maximal level at metaphase, however disappeared in the plasmodia of anaphase and telophase

    Westernblotting分析結果表明， cyclinb存在於s期、 g _ 2期、前期和中期的原質團中，分子量約為62kda ， cyclinb的含量從s期到中期逐漸增加，特別是有絲分裂前期增加明顯，中期原質團cyclinb含量最高，后末期原質團中沒有cyclinb 。
  3. In addition to cyclin b, p34cdc2 can be activity or in activity in three site thrl4, tyrl5 and thr 161

    『 」濃度，我們在選擇oag的濃度時，則應注意oag的加人不要影響到細胞內ca濃度的改變。
  4. Cyclins are important proteins in regulating cell cycle, which form the holo - enzyme complex with cdk as a triggering factor in the cell cycle, the assembly and activation, degradation of cyclin - cdk holo - enzyme complex is the main molecular basis of cell cycle regulation

    細胞周期蛋白（ cyclin ）是調節細胞周期活動的重要蛋白質，它們與細胞周期蛋白依賴性激酶（ cyclindependentkinase ， cdk ）共同形成的全酶復合體是細胞周期的正性驅動分子。
  5. All different cyclins found in mammalian cells contain a 100 amino - acid homologous region named cyclin box, which is the molecular structure marker of cyclins. the expression level of cyclins shows cell cycle phase specialty. it can be regulated by transcription and the degree of protein hydrolysis

    在哺乳動物細胞發現的12型細胞周期蛋白中均含有一段由100個左右氨基酸組成的保守區，稱為周期蛋白盒（ cyclinbox ） ，它是細胞周期蛋白的分子結構標志。
  6. Interventional effect of chinese herbal compound digan oral liquid on cyclin genes and adherent molecules of hematopoietic stem cells and stromal cells in bone marrow of mice with irradiative injury

    中藥復方地甘口服液對輻射損傷小鼠骨髓細胞周期素基因及造血幹細胞和基質細胞黏附分子的干預效應
  7. The protein level of p21 increased lightly from 1 to3 h, then decreased at 6 - 9 h, reached maximum at 24 h after 2gy, it increased from 3 to 24 h exposed tology, and the protein level of p21 associated with cdk2 increased, which did not inhibit the cyclin e / cdk2 kinase activity, because of upregulation of cyclin e and deregulation of p27kipl after irradiation. in contrast to p21, p27kipl may be a key regulator of cyclin e / cdk2 activity in dna damage responses. hi the ubiquitin - proteasome pathway invovled in regulation of p27kiplexpression in response to ir the ubiquitin - proteasome pathway regulated selective and time - controlled elimination of p27 kipl

    與p27ki 」 ，表達水平不同， pzi蛋白表達水平在zgy照射后略有增加， 6一gh略有下降，在照后24h達到最大; 10gy照后1一3h開始增加，持續到24h ，並且cycline / cdkz復合物中pzi蛋白結合增多，但cycline / cdkz激酶活性並未受到抑制，除了因ir誘導cydine蛋白表達水平增加外，另一重要的原因就是與pzi同一家族的p27kip ，蛋白表達水平下降，失去了對cycline / cdkz的抑制活性。
  8. In this article, we microinjected camp ( as activator of pka ) and protein kinase inhibitor ( pki ) ( as inhibitor of pka ) into mouse 1 - cell stage fertilized eggs, the camp concentration, pka and mpf activaty were detected, also the cdc25c, cdc2 phosphorylated state and the concentration of ptyr15 for cdc2, cyclin b1. materials females of 4 - 5 week - old kuming mice and males of 8 week - old kuming mice were supplied from the department of laboratory animals, china medical university

    本實驗應用pka激動劑camp及抑制劑pki顯微注射入小鼠二一細胞期受精卵並觀察卵細胞m期形態學變化及pka對mpf活性的影響以及cdc25c ， cdcz電泳遷移率， cdcz的磷酸酪氨酸ptyrl及周期素b含量，為揭示pka在哺乳動物細胞周期調控機制，對生長、發育、癌變、死亡的研究提供理論依據。
  9. To investigate the functions of these factors, cells were treated with anti - c - fos, anti - c - jun and anti - ras antibodies and examined microscopically for the cell cycle progression. the results indicated that c - fos - like protein, c - jun - like protein and ras - like protein played important roles in checkpoint regulation in physarum polycephalum. western blot analysis showed that the c - fos - like protein and c - jun - like protein may act in cell cycle checkpoint by changing the cyclin b1 - like protein and p53 - like protein expression ; and the ras - like protein may act by changing the cyclin bl - like protein, p53 - like protein, c - fos - like protein and c - jun - like protein expression

    蛋白免疫印跡分析的結果表iv明，當s期、 gz期和前期細胞內具有功能活性的類ras蛋白的量減少時，細胞中的細胞周期調控因於類cyclinbi蛋白、類c jun蛋白、類c fos蛋白和類p53蛋白的表達水平，與未經抗體處理時相比發生了變化（或升高或下降） ；而山抗體處理引起的多頭絨泡菌細胞內具有功能活性的類c fos和類c jun蛋白的減少，使細胞內類cyclinbi蛋白和類p53蛋白的表達水平與抗體未處理時相比也發生了明顯的改變。
  10. In xenopus embryonic extracts camp concentration and pka activity also oscillations accompany with the cell cycle, low in mitosis and increased during m / g1 transition, keep high until next mitosis, and the mechanism concern with the cdc25 phosphorylation state and cyclin b concentration. mouse fertilized egg is the most simple and natural model for cell cycle that near to human, but little is know about pka on mpf also pka on mitosis

    通過對非洲爪贍胚胎細胞周期的研究發現jka活性也隨細胞周期變化而波動，在m期出現時pka活性下降，而m間期轉換時pka活性達最大值，一直維持高值直到下一個m期出現，其對mpf活性調節與cdc25磷酸化狀態及周期素b表達有關。
  11. Free cyclin level is low for they quickly bind with cdc2, the total cyclin mainly exist in mprty ( pre - mpf ) ml to m2 process ; all the elements are set to g2 arrest concentration, then we set pka - > ipka rate = 0. 1 to simulate progesterone effect, ( it has been reported that progesterone can decrease the camp level, thus causes pka inactivation ) mpf activity rise at ml, falls at the inter phase between ml and m2, and then remains high at m2 arrest

    ： 22 nxm m dt 『 ? ? 「 ? 『民十cd 。 251 i ： vj rccjc25 pi然後，我們應用gepasi來進行這個模型的計算機模擬結果爪群卵成熟過程的模型模擬gz期阻滯，總的cyclinb的含量雖然升高，但是mpf保持在低活性狀態，隨著pka的失活， mpf活性有戲劇性的變化，它的活性在mi升高，在問期下降，然後又在mz期升高，最後停留在高活性的mz期。
  12. Activation of a cdk requires binding to a specific regulatory subunit, termed a cyclin

    Cdks的活化需要結合一種特異的調節亞基- cyclin 。
  13. They are positive regulating proteins and play a very important role in the development of neoplasma. cki are negative regulators taking part in cell cycle, which can directly or indirectly combine with the corresponding cdks to inhibit their activity. cyclin - cdk - cki constitutes a complex network regulating cell cycle

    細胞周期蛋白依賴性激酶抑制因子（ cyclindependentkinaseinhibitors ， cki ）可直接抑制相應的cdk活性或通過與cyclin競爭性結合cdk而起到抑制cyclin - cdk復合物的活性，從而作為負性調節因子參與細胞周期調控。
  14. The protein level of cyclin e increased lightly after 2gy, but it increased from 1 to 24 h after logy, level of cyclin e associated with cdk2 increased in response to logy, at the same time, there was no significant changes in the level of cdk2, while cdk2 levels remained constant in hela cells. our results indicated that the kinetics of cyclin e / cdk2 kinase activity reflected the increase in cyclin e expression levels

    Cycline蛋白表達水平在zgy照射后略有增加， 1ogy照射后lh開始增加，持續到24h ，但ir后cdkz蛋白水平未發生變化，通過免疫共沉澱檢測了10gy照射后edkz與cydine結合，發現隨著照射時間的延長， cycline與cdkz結合量增多，這說明cycline蛋白水平的增加能反映cycline / cdkz的激酶活性。
  15. Situation of p27 and cyclin e in the study on hypophyseal tumor

    在垂體腫瘤研究中的現狀
  16. Together, these cyclin / cdk complexes are the universal cell cycle regulators, with each complex controlling a specific transition between the subsequent phases in the cell cycle

    Cyclin cdk復合物作為廣泛的影響細胞分裂調節物而發揮作用。每一種復合物參與不同的細胞周期各時段的調控。
  17. The amounts of cyclin b changes due to the phase of cell cycle. in gl phase, cyclin b start to be synthesized, getting more and more and the highest of amounts in the late of g2 phase

    而ca從濃度升高降低p34 」怕是通過使thr161脫磷酸化及cylcinb7k解，同時使p34 」帕一cyclinb復合物分解。
  18. Mpf is a complex that consists of the protein kinase p34cdc2 and the regulatory protein cycli b ; the protein kinase activity of p34cdc2 is strictly dependent on its association with cyclinb. in xenopus laevis eggs the absent of cyclin b, mpf will not be activited

    Ca卜活化p34 」擬的機制第一步是結合cycinb ，並且處于磷酸化狀態，即thr14 、 tyrls和tlirl61都處于磷酸化狀態；第二步是cdc25磷酸酶通過是thr14 、 tyr15脫磷酸化而激活p34 」擬。
  19. Cdc2 is regulated by two pathways, one is the combination with cyclin b, and the other is the phosphorylation of itself. when the tyr15 is phospholated, the mpf is inactive and the transfer from g2 phase to m phase is inhibited

    Cdc2的活性調節機制有兩種，一是與受cyclinb結合的情況；其次就是它自身多種氨基酸殘基的磷酸化狀態，其中當tyr15處于磷酸化狀態時， mpf無活性，從而抑制g2 m的轉換。
  20. Cyclins help control progress through the various stages of the cell cycle by activating protein kinases ( cyclin - dependent protein kinases )

    它可以通過激活蛋白激酶來調節細胞周期中各個階段的進行（細胞周期蛋白依賴性的蛋白激酶） 。
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