dead vaccine 中文意思是什麼
dead vaccine
解釋
滅活疫苗-
Researches of schistosomiasis vaccines have gone more than 60 years, approximately including from the stages of dead vaccine and live vaccine ( irradiated attenuated cercariae vaccine ) to gene engineered vaccine, etc. many different forms of vaccines have been tested in animal models, including gluthathione s - transferase, paramyosin, irv - 5, triose phosphate isomerase, sm23, fatty acid binding protein ; which were considered promising by who / tdr. but none of them steadily accomplished the pre - set target level of 40 % protection. in order to enhance the protective capacity further, it is essential to develop novel vaccine antigens and / or vaccine adjuvants
血吸蟲病疫苗研究已有60多年的歷史，大致經歷了死疫苗、活疫苗（照射致弱尾蚴疫苗）和基因工程疫苗等研究階段，產生了一些who / tdr推薦認為很有希望的疫苗候選分子，如谷胱甘肽- s -轉移酶（ gst ） 、副肌球蛋白（ sm97 ） 、照射致弱疫苗抗原5 （ irv - 5 ） 、磷酸丙糖異構酶（ tpi ） 、曼氏血吸蟲膜內在蛋白（ sm23 ）和脂肪酸結合蛋白（ fabp ， sm14 ）等，但其對宿主的保護作用均不甚理想，未能穩定地達到40或以上的保護力水平，因此有必要繼續尋找新的疫苗抗原分子和/或疫苗佐劑，進一步提高其保護力。 -
Yherefore, many researchers have shown great concern with the development of vaccines to against schistosomiasis. at early stage, the research of vaccines of schitosomiasis was centered on dead vaccine and athenuated cercaria of schistosomes while molecular vaccine and athenuated cercaria of schistosomes while molecular vaccine is currently the focus of research with anti - infection protective immunity as its main concern. guan xiaohong and zhao weixian ( 1986 ) certified that the allergen of egg granulonma of schistosoma japonicum might firstly come from gut associated antigen ( gaa ) of schistosomula and adult worm and that daa had cross reaction with soluble egg antigen ( sea ) and membrane associated antigen ( maa ) ; and the gaa of schistosoma japonicum might play a sensitizing role in egg granuloma formation
Np30主動免疫c57bl 6對尾蚴攻擊感染產生42 . 05的保護力，肝組織減卵率為66 . 63 ； balb c和昆明種小鼠的保護率分別為39 . 53和50 . 46 ；免疫山羊可誘導42 . 78的減蟲率，肝組織減卵率為35 . 83 ，糞減卵率為25 ，並可明顯抑制肝臟蟲卵肉芽腫的大小，肉芽腫數量明顯減少，纖維化減輕，體重明顯增加，因此np30是南京醫科大學博士學位論文很有希望的抗日本血吸蟲病疫苗侯選分子。 -
Now vaccine precaution is the optical way to control the diarrhea, but the effect of the dead vaccine was not good and the live vaccine would cause the diffusion and environment contaminate
目前疫苗預防仍是控制此病的最佳選擇，但常規苗存在死苗用量大且效果不好，活苗容易造成擴散和環境污染等缺點。
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