extracellular microelectrode 中文意思是什麼
extracellular microelectrode
解釋
細胞外微電極- extracellular : adj. 【生物學】細胞外的 （opp. intra-cellular）。
- microelectrode : 微電極
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A c a2 + / calmo dul in - dep endent pro te in kinas e i i ( c amkii ) antagoni st kn - 6 2 ( 5x l0 - ' mol / l ) presented in the intemal solution had no significan effect on the current peaks induced by extracellular nmda ( l0 # mol / l ), but prevented the inhibitory effect of b on inmda " these results indicate that gcs have rapid, reversible idebitory effects on lnmda intracellular application of b thiough microelectrode had no effect on inmda, howevet, extracellular application of b or b - bsa suppressed peaks of inmda : all these denote b exerts its influence on nmda receptor by cytoplasm membrane mechansms, which is naxnely rapid, nongenomic mechhasms
加有快速、可逆的。非濃度依賴性抑制作用。通過微電極將b直接導入細胞內， inmda不受影響，而胞外給予b或besa ， inmda減小，提示b對nmda受體的調控通過膜機制產生，這種作用與經典的基因組機制不同；因為廣譜激酶抑制劑和特異的pka抑制劑均可翻轉b的抑制效應， camk11抑制劑也可阻斷b的效應，而這些激酶抑制劑本身對inmda即有強烈的抑制作用： pka激動劑本身對inmda無明顯作用，也不影響b對l 。 -
Electrophysiological experiment : in 73 rats, extracellular recordings in vivo were made from pvn using 3 - barrel microelectrode. neurons were categorized as gastric distension excitatory ( gd - e ) or inhibitory ( gd - i ) neurons tested with gastric distension stimulus. drugs were applied through the 3 - barrel microelectrode by a 4 - programmable pressure injector ( pm2000b, mdi, usa ) : relin, saline ( control group ) relin, " [ d - lys - 3 ] - ghrp - 6 ( antagonist for ghrelin - r ), to observe the effects of drugs on the neuron discharge
電生理實驗方法：在73隻大鼠中，應用三管玻璃微電極細胞外記錄麻醉大鼠一側pvn神經元自發放電，用水囊充盈胃鑒別胃擴張敏感神經元（ gdsn ） ，以壓力注射儀（ pm2000b ， mdi ， usa ）經三管玻璃微電極，對核團內中文摘要單個神經元分別微量注射給予: ghrelin 、生理鹽水ns （對照） ghrelin 、 d一lys一3 ]一ghrp一6 （ ghrelin受體拮抗劑） ，觀察藥物對神經元單位放電的影響。
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