gtp-binding 中文意思是什麼
gtp-binding
解釋
g蛋白即gtp結合蛋白-
Homologues of era have been identified in prokaryotes and eukaryotes. there are two domains in era : the n - terminal gtp - binding domain and c - terminal rna binding kh domain. era plays an important role in cell cycle progression at a specific point in the cycle, after chromosome partitioning but before cytokinesis
Era是在原核和真核生物以及植物中普遍存在的g蛋白，是一個結構上既具有gtp結合結構域又有rna結合結構域、不同於ras的獨特的新的g蛋白亞家族。 -
Rab7 mediates transport of proteins from early endosome to late endosome or fusion of early endosome with late endosome, while rab9 mediates the retransport of m6pr from late endosome to trans - golgi network. the gtp / gdp - binding ability and intrinsic gtpase activity of rab proteins make them exist in rab - gtp or rab - gdp status. the switching of rabs between gtp - bound ( active ) and gdp - bound ( inactive ) forms requires other regulatory proteins, including guanosine exchange factor ( gef ), gdp dissociation inhibitor ( gdi ) and gtpase activating protein ( gap ), and lays the foundations of rab function
Rab蛋白家族成員和其他小g蛋白一樣可以結合gtp gdp ，在自身gtp酶的水解作用和其他蛋白（ gef 、 gap 、 gdi ）的調節作用下發生gtp （活化狀態）和gdp （無活性）結合形式的轉變；同時rab蛋白也在膜結合性（ membrane - bound ）和胞漿可溶性（ cytosolic ）之間變化，一個變化過程對應著一個功能循環，接著rab蛋白回到初始狀態參與下一個循環。 -
Rapl belongs to ras superfamily of small gtp - binding proteins, which is considered to control cell growth, differentiation and survival. rapl was regarded as an antagonist of ras because it can revert the phenotype of oncogene ras transformed cells. recent researches show that rapl has its ras - independent functions in a variety of cellular systems besides its effect as an antagonist of ras
Rap1除具有逆轉原癌基因ras激活突變體所導致的細胞形態改變而被認為是ras的拮抗物外，最近的研究還發現rap1在一系列的細胞系統中有獨立於ras之外的功能，如控制與細胞粘附有關的事件等，因而成為研究的熱點。
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