hirudin 中文意思是什麼
hirudin
解釋
n. 名詞 【生物化學】水蛭素。-
Hirudin ; rgd sequence ; chimeric antithrombotic
水蛭素rgd序列嵌合抗栓劑 -
Construction and expression of chimeric antithrombotics with hirudin and rgd sequence
含rgd序列水蛭素嵌合抗栓劑的構建與表達 -
Protective effect of hirudin against apoptosis on cultured rat brain microvascular endothelial cells
水蛭素對凝血酶所致腦微血管內皮細胞損傷的保護作用 -
Abstract : hirudin is the potent antithrombotic factor found in nature. hirulog is a dind of peptides designed by imitating hirudin
文摘:水蛭素是迄今發現的最強的天然凝血酶抑制劑，水蛭肽是模仿水蛭素與凝血酶的相互作用機制而合成的肽類化合物。 -
This paper introduces their mechanism, function and clinical research, illustrates their advantages compated with heparin, believing that both hirudin and hirulog are new promising antithrombotic agents
本文介紹了他們的作用機理及其臨床研究，敘述了他們與肝素相比的優越之外，認為水蛭素與水蛭肽是兩類非常有前途的抗栓新藥。 -
Based on the structure and function analysis of hirudin, a potent thrombin inhibitor, and some platelet aggregation inhibitors, which contain the recognition sequence argglyasp as their functional motif, two chimeric antithrombotic molecules were designed by introducing rgd sequence to hirudin cterminus. these chimera genes were constructed by pcr and inserted into the expression vector pet21a, the constructs were confirmed by restriction enzyme digestion and dna sequence analysis. these recombinant plasmids were transformed into
經限制酶消化和dna序列分析，證明兩種重組質粒與設計完全一致。由於rgd -水蛭素嵌合基因上游連接了金黃色葡萄球菌蛋白a spa的信號肽序列，在iptg誘導下兩種嵌合分子都獲得了分泌表達，表達產物主要集中在細胞周質空間。 -
Strain bl21, and gene expression was induced by iptg. the target proteins were directed into the periplasmic space by the staphylococcal protein a signal sequence preceding the rgd - hirudin gene. using ion exchange chromatography and gel filtration chromatography, the chimera proteins were purified, and both of them showed a single band in tricine - sds - page. the results of activity analysis suggested that these two chimera proteins not only have antithrombin activities, but gain platelet aggregation inhibitory activities as well
通過離子交換層析和凝膠過濾層分別對兩種嵌合體蛋白進行純化，純化產物在tricine - sds - page中都顯示為單一條帶。活性分析結果表明兩種嵌合體蛋白在保留水蛭素抗凝血酶活力的同時，還呈現抗血小板聚集活性。
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