histone modification 中文意思是什麼

histone modification 解釋
組蛋白修飾
  • histone : n. 【生物化學】組蛋白。
  • modification : n. 變更，更改，修正；改良，改進；緩和；修改；減輕；限制；【生物學】誘發變異，變態，變體，變型；【語法】修飾；（用變音符號的）母音改變。
  1. These issues are essential to the understanding of the nature of cell cycle control, and to elucidating the roles of the histone acetylation modification in cell cycle regulation in eukaryotes. in this thesis, we studied the mechanisms of histone acetylation in cell cycle regulation in physarum polycephalum, a naturally synchronized slime mold. the results of this study confirmed that histone acetylation changed the expression of proteins related with the regulation of checkpoint conversion in cell cycle

    初步確定了組蛋白乙酰化在多頭絨泡菌細胞周期各轉換點的調控過程中對細胞周期調控相關蛋白表達水平的調節作用；了解了組蛋白乙酰化修飾對細胞周期各轉換點調控的作用途徑；建立了組蛋白乙酰化修飾對多頭絨泡菌細胞周期調控機制的基本模型。
  2. Epigenetic modification of the genome ensures proper gene activation during development and involves : genome methylation changes ; the assembly of histon and histone variants into nucleosomes and remodeling of other chromatin - associated proteins such as linker histones, polycomb group, nuclear scaffold protein, and transcription factors

    這些染色質的再程序化包括dna的甲基化和核小體組蛋白的乙酰化等。組蛋白乙酰化在染色質結構調節、 dna復制、基因轉錄、細胞分化及癌細胞發育都有研究，但在克隆動物中卻是一個有待深入探索的領域。
  3. By treating the cells in s, g2 phase and prophase with histone deacetylase inhibitor tsa, and through the application of microscopic observation and western - blotting, we demonstrated that histone acetylation modification played important roles in the cell cycle regulation in physarum polycephalum, affecting the normal crossover of the checkpoints of s / g2, g2 / m and mitosis exit

    這些炎白的表達水平具有細胞周期依賴性，隨著細胞周期的進行而發生變化。 tsa處理引起的多頭絨泡菌s期、 gz期和前期細胞內組蛋白h3乙酚化水平的提高，改變了細胞內類cyclinbi蛋白、類。
  4. We do not know what cell cycle - associated proteins are regulated by histone acetylation modification, especially at the checkpoints of g1 / s, s / g2, g2 / m and mitosis exit. neither do we know about the manner in which histone acetylation regulates the expression of these genes

    在真核細胞周期調控的重要檢驗點g1 / s和g2 / m ，以及其他的轉換點s / g2和走出m期的各個過程中，哪些細胞周期調控相關蛋白的表達活性與細胞內的組蛋白乙酰化水平相關
  5. As a test to determine whether such histone modification functionally affected plasticity, the researchers administered a drug to adult mice that would increase chemical modification of histone

    為了確定組蛋白的化學修飾是否對大腦可塑性產生功能上的影響，研究人員做了一個試驗，即給予成年鼠服用一種能夠增加組蛋白化學修飾的藥物。
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