homodimerization 中文意思是什麼
homodimerization
解釋
均二聚-
Gfral is an extracellular protein that is attached to the outer cell membrane by gpi - anchor and could not transducted signalling directly. according to the original model, a gdnf dimer first binds to either monomeric or dimeric gfral, and the gdnf - gfral complex then interacts with two ret molecules, thereby inducing their homodimerization and tyrosine autophosphorylation
傳統觀點認為： gdnf首先與gfr 1結合形成gdnf - gfr 1復合物，此復合物再與ret結合形成三聚體復合物，引起ret的二聚化，並引起酪氨酸殘基自磷酸化，從而引起下游的信號轉導。
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