integrin family 中文意思是什麼
integrin family
解釋
整合素家族-
Cell adhesion to surface of the substrate is essential to development of the anchorage - dependent cells. only after adhering to surface followed by spreading can cells develop and proliferate. most synthetic polymers used as orthopaedic matrix substitute present hydrophobicity, which may correlates to the low degree of cell attachment. modification with cell adhesion protein / peptides can be benificial to the cell adhesion on polymers and then affect the cell proliferation and differentiation. cell attachment to substrate is primarily mediated by integrins, a widely expressed family of heterodimeric surface receptors. most extrcellular matrix proteins such as fibronectin, osteopontin, collagen type i, bone sialoprotein and vitronectin contain an arg - gly - asp ( rgd ) sequence which is specific to the fixation of cell membrane receptors like integrin. the main aim of this research is to measure, assess adhesion, proliferation of rabbit marrow stromal cells ( mscs ) on the polymers coated by fibronectin, collagen type i or biotie gen, which includes : ( 1 ) biologic characteristics of rabbit mscs were observed by two types of separating method in primary culture. ( 2 ) adhesion, proliferation and differentiation of mscs cultured on polymers coated with biotiegen were assessed. ( 3 ) also, adhesion, proliferation and differentiation of mscs were assessed on plga film or porous plga substrates coated with fibronectin, or collagen type i respectively. ( 4 ) bone formation was observed on the porous plga substrates coated with collagen type i in vivo. this research aims to give new way to make novel synthetic bone with cell adhesion and high bone induction capabilities
因此將這些蛋白包被、固定到材料表面，觀察骨組織工程種子細胞mscs細胞的粘附、生長特性是本研究的中心環節，並從以下方面進行探討： （ 1 ）採用不同原代細胞分離方法，研究其對mscs細胞的生物學特性影響。 （ 2 ）檢測基因勝肽膠對mscs細胞粘附、增殖及分化的影響。 （ 3 ）分別採用型膠原及纖維粘連蛋白（ fibronectin ， fn ）包被聚乙醇酸-乳酸共聚物（ poly （ 1actide - co - glycolide ） ， plga ）膜及多孔塊型plga材料，觀察細胞在單層或三維培養狀態下，型膠原及fn對mscs細胞粘附、增殖及向成骨細胞分化效應及能力。 -
The identified proteins are involved in a variety of cellular process including several zinc finger proteins relevant to transcription regulation, such as zinc finger 198, 263, 14, 224, zf6, novel protein similar to transcriptional represser ctcf, and kruppel - like zinc finger protein ; two members of the adams ( a disintegrin and metalloprotease domain ) family ; two members of integrin family ; several proteins involved in the signal transduction, cell - cycle control, chromatin remodeling and transcription repression ; and also some proteins of cell skeleton and some with unknown functions
鑒定出的蛋白包括多個與轉錄調控相關的鋅指蛋白，如鋅指蛋白198 、 263 、 14 、 224 、 zf6 、轉錄抑制因子ctcf樣蛋白、幻肚pple樣鋅指蛋白等:兩個含金屬蛋白酶結構域和整合素結合結構域的家族成員adam28和adam17 ;兩個整合素家族成員pz整合素和含十個egf樣結構域的整合素（ tied ） ;與細胞信號轉導通路有關的蛋白;與細胞周期調控有關的蛋白;與染色體重塑和基因轉錄抑制有關的蛋白;細胞骨架蛋白以及其他功能未明的蛋白等。 -
There are so many molecules involved the fertility, such as : spl7, a mammalian testis - and sperm - specific protein, can specifically bind with zona pellucida, dextran, dextran sulfated, and fucoidin. another germ cell cyritestin is a testis - and sperm - specific protein belonging to the adam family. it has a disintegrin domain at the n - terminal, known as a integrin ligand, that suggests cyritestin could be involved in sperm adhesion and fusion with the egg membrane previous study demonstration
配子中的許多分子均參與了上述關鍵環節，如在精母細胞、精細胞和睪丸精子中表達，並特異性與卵子透明帶糖蛋白、葡聚糖、糖酐脂結合的精子表面蛋白17 （ sp17 ） ，以及參與識別或與卵子膜上的整合素相互作用的adam家族成員之一的cyritestin蛋白等。 -
Results : 5 1, a member of the integrin family, has strong correlation with tumorigenicity, development and metastasis
結果： 5 1是整合素家族的一員，參與腫瘤的發生、發展與轉移。 -
1 -. studies on the inhibition of angiogenic properties by monoclonal antibody against integrin endothelial cell adhesion and migration are important processes during angiogenesis. the capacity of endothelial cells to recognize and migrate in response to the extracellular matrix ( ecm ) depends on one or more members of the integrin family of cell adhesion receptors
血管新生的過程依賴于參與血管生成的細胞因子和細胞粘附的協同作用，整合素（ integrin ）是一組細胞表面受體，介導細胞-細胞間、細胞-基質間的相互作用，對內皮細胞的粘附、遷移、增殖起重要作用。
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