lymphocyte activation 中文意思是什麼
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It has been demonstrated that complement activating and cr2 cross - linking on b lymphocytes set up a bridge between innate and acquired immunity. the interaction of c3 and cd21 on b lymphocytes will benefit initiating immune response and regulating primary antibody response. cd21 / cd35 is important in the process of antibody avidity maturing, this is critical to b lymphocyte activation especially in the state of low antigen concentration
現己證實補體的活化以及b細胞表面crz的交聯在先天和獲得性免疫之間架起了重要的橋梁，表現為c3與b細胞cdzi的相互作用有利於啟動抗體應答反應，並對初級抗體應答反應有調節作用： cdzi cd35對于抗體的親和性成熟具有重要作用，在抗原濃度低的情況下，對于活化b細胞是至關重要的，而且mlgm （交聯有利於特異的低親和性b細胞對t細胞依賴性抗原和t細胞非依賴性抗原產生免疫應答。 -
T cell will be apopotosis, clone depletion and / or anergy, in turn inducing an antigen - specific tolerance. ctla4 ( cytotoxic t lymphocyte associated antigen 4 ), a prominent negative costimulator, can competitively bind with b7, and block b7 - cd28 pathway and t cell activation by producing inhibitory singals
Ctla4 （ cytotoxictlymphocyteassociatedantigen4 ）作為一種主要的共刺激負調節劑，可競爭性結合b7分子，阻斷b7 - cd28途徑、並通過產生抑制性信號使t細胞活化障礙。 -
Chemotaxis mediated by chemokine receptors, such as cxcr4, play a key role in lymphocyte homing and hematopoiesis as well as in breast cancer metastasis. we have previously demonstrated that ? - arrestin2 functions to attenuate cxcr4 - meidated g protein activation and to enhance cxcr4 internalization. here we further show that expression of ( - arrestin2 in both hela and hek293 cells significantly enhanced the chemotactic efficacy of stromal - cell derived factor 1 ( ( sdf - 1 ( ), the specific agonist of cxcr4
- arrestin2是趨化因子受體的一種重要的調節蛋白，本研究工作發現在hek - 293或hela細胞中升高- arrestin2的表達水平會顯著增強cxcr4介導的趨化作用，反之當- arrestin2的表達被它的反義核苷酸或rnai所抑制， cxcr4介導的趨化作用則被明顯抑制。 -
It is interesting that pma plus calcium ionophore a23187 can inhibit pma - induced pta1 expression, and this effect ca n ' t be reversed by calcmeurin inhibiter fk506. pta1 mabs can inhibit ctl activation and differentiation in mixed lymphocyte culture system when added at the beginning of the culture but can induce platelet activation and aggregation in the fc dependent manner. in 1997, pta1 cdna was cloned from cdna library of tpa activated jurkat cells, which belongs to immunoglobulin superfamily ( igsf ) with two v - like domains of extracelluar region of pta1
Il - 2 、 tnf - 、 pma可以使t細胞pta1表達上調， tgf -可以下調pta1的表達，而pma加上鈣離子載體a23187可以顯著抑制pma的上調作用，且這種抑制作用不被calcineurin抑制劑fk506所逆轉， 1997年burns教授從pma活化的jurkat細胞cdna文庫中克隆了pta1cdna全長，證實pta1是一個新分子，屬于免疫球蛋白超家族，胞膜外區有兩個v樣結構域。 -
The direct interplay between tumor cells and immune cells could inhibit the immunostimulatory function of dendritic cells ( dc ). more interestingly, tumor cells or tumor tissue could release inhibitors of lymphocyte activation
已有的報道表明，與腫瘤細胞相互作用可以抑制這些免疫細胞包括樹突狀細胞（ dc ）的免疫激發功能，並且在腫瘤的局部抑制dc細胞的功能，並使其數量減少。 -
Macrophage is a kind of immune cell as well as accessory cell. it can function as antiinfection, anticancer, immune response and immunoregulation by phagocytosis, antigen presentation, cytokines secretion, lymphocyte activation, reactive oxygen and no production. it ' s an important part of body immune system
巨噬細胞（ macrophage ）既是免疫細胞，又是輔佐免疫應答細胞，可通過吞噬、抗原呈遞、分泌細胞因子、激活淋巴細胞和產生活性氧、 no等作用而行使抗感染、抗腫瘤、免疫應答和免疫調節作用，是機體免疫系統的重要組成部分。 -
Changes of activation and apoptosis of t - lymphocyte in peripheral blood of patients with copd and their clinical significance
淋巴細胞活化與凋亡的變化及臨床意義
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