n-terminal residue 中文意思是什麼

n-terminal residue 解釋
n端殘基
  • n : 1. 【羅馬數字】90〈N=90000〉。2. 【化學】=nitrogen. 3. =North(ern)。N =nuclear 核的:N-waste 核廢料。
  • terminal : adj 1 終端的,終點的,結尾的;極限的。2 定期的,每期[季]的;每學期的,學期終[末]的。3 期終的;末...
  • residue : n. 殘余,殘渣,餘款;【林業】廢材,木屑;【法律】剩餘遺產,余產;【化學】殘基;濾渣;余渣,殘余物;【數學】殘數,留數,余數。 for the residue 至於其餘;說到其他。
  1. The pocket accommodating the aromatic ring of phenylalanine is formed predominantly by hydrophobic side - chains, including those of ile10, ile13, prol50, leul75, leul79, phe209, ser211 and val221 ; whilst the amino group and carboxylate group of phenylalanine is coordinated by asp6, asp7, gln151 and ser180. the n - terminal region is found to be important to the function of arog. point mutation reveals that residue substitution of ilelo to ala10 leads to desensitization in the presence of 1 mm phenylalanine, simultaneously, exhibits a dramatic decrease in enzymatic activity

    綜合前人的研究和本研究工作的實驗數據,得出以下結論: 1 )在arog的反饋抑制位點供苯丙氨酸結合的疏水口袋由asp6 、 asp7 、 ile10 、 ile13 、 pro150 、 gln151 、 leu175 、 leu179 、 ser180 、 phe209 、 ser211和val221等12個氨基酸殘基構成; 2 )苯丙氨酸結合的疏水口袋分為兩個區域,與苯丙氨酸的苯環發生疏水作用的區域由ile10 、 ile13 、 pro150 、 leu175 、 leu179 、 phe209和val221的側鏈構成,而asp6 、 asp7 、 gln151和ser180的側鏈構成了與苯丙氨酸的氨基和羧基相互作用的區域。
  2. These results unambiguously demonstrate that a single amino acid residue substitution is sufficient to generate a phenylalanine - insensitive form of arog. furthermore, the mutant a ( l - 15 ) lacking the first fifteen n - terminal amino acid residues exhibits no sensitivity toward phenylalanine in a range of 0 ~ 1 mm phenylalanine

    這些結果揭示: 1 ) n一末端在反饋抑制機理中具有重要作用; 2 ) n一末端的缺失使得ar0g緊密二聚體結構解聚,導致四級結構破壞。
分享友人