pancreatic cystic fibrosis 中文意思是什麼
pancreatic cystic fibrosis
解釋
胰囊性纖維變性- pancreatic : adj. 胰(腺)的。
- cystic : adj. 1. 膀胱的;膽囊的。2. 胞的,囊的。3. 胞狀的,囊狀的;有胞的,有囊的。
- fibrosis : n. 【醫學】纖維變性,纖維化。
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Cystic fibrosis is caused by mutations in the gene encoding an ion - transport protein, the cystic - fibrosis transmembrane conductance regulator ( cftr ). defective secretion of anions is the primary cause of many of the clinical manifestations of cystic fibrosis, including pancreatic insufficiency
囊性纖維化是由作為陰離子通道的跨膜電導調節器( cftr )的基因突變所致,而陰離子分泌缺損是囊性纖維化的多種臨床表現(包括胰腺功能缺陷)的主要原因。 -
The newly identified gene, nyd - sp27 has structural similarity to an isoform of phospholipase c. nyd - sp27 was expressed endogenously in human pancreatic - duct cells and upregulated in cystic fibrosis. researchers has proved that suppression of the gene resulted in augmentation of phospholipase - c - coupled calcium - ion release and protein kinase c activity, improvement in the amount of mutated cftr reaching the plasma membrane, and thus restoration of pancreatic anion secretion
Nyd - sp27內源性表達在人體的胰腺導管上皮細胞,並在囊性纖維化時表達增高,顯示該基因可能與病變有關。研究人員發現通過抑制該基因在人體囊性纖維化胰腺導管細胞中的表達,可以糾正缺陷的胰腺陰離子分泌。 -
Researchers at the epithelial cell biology research center of the faculty of medicine, the chinese university of hong kong, and their collaborators from the nanjing medical university have recently cloned a new gene related to pancreatic insufficiency in cystic fibrosis
香港中文大學上皮細胞生物學研究中心與南京醫科大學的合作研究,發現並成功克隆一個與囊性纖維化所致胰腺功能缺陷相關的新基因。 -
Professor chan hsiao chang, director the epithelial cell biology research center explained, " the upregulation of nyd - sp27 in pancreatic - duct cells may reveal a previously unsuspected defect in cystic fibrosis contributing to pancreatic insufficiency, and thus represents a new target for pharmacological intervention in cystic fibrosis.
負責該項研究的香港中文大學生物學研究中心主任陳小章教授指出,該基因在囊性纖維化胰腺的高表達,顯示一種以前未曾為研究人員注意到的導致胰腺功能缺陷的病理機制,而實驗結果提示該基因可能成
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