pka 中文意思是什麼

pka 解釋
電離常數
  1. Comprehensive cellular responses was found in human amnion fl cells following exposure to low concentration of mnng, such as the lowering of dna replication fidelity resulted from alteration of dna polymerase profile ; activation of a lot of transcription factors, such as api, creb, nf - kb etc ; clustering of egfr ( epidermal growth factor receptor ) and tnfr ( tumor necrosis factor receptor ) and activation of camp - pka - creb and jnk / sapk signal pathways

    我們發現，低劑量mnng處理后的人羊膜fl細胞有廣泛的細胞反應，並有多個信號轉導通路的激活和基因表達的改變。例如dna復制保真度下降， dna聚合酶譜發生改變，應用報告基因技術和底物磷酸化檢出技術證明細胞一系列轉錄因子如ap1 、 creb 、 nf b等被激活，細胞表面受體如表皮生長因子受體、腫瘤壞死因子受體發生聚簇，細胞信號轉導通路camp - pka - creb和jnk sapk被激活。
  2. Camp, pka inhibitor peptide ( pki ), kemptide, histone h1 ( type iii - s ), polyvinyl alcohol, na3vo4, naf, b - glycerophosphate, p - nitrophenylphosphate, 3 - [ n - morpholino ] - propanesulfonic acid ( mops ), genistein, ml - 9, leupeptin, aprotonin, pepstatin, chymostatin, trypsin - chymotrypsin inhibitor were purchased from sigma chemical co. [ r - 32 p ] atp was obtained from yahui biomedical enginnering co

    實驗材料昆明系小白鼠，中國醫科大學實驗動物部提供。測活用試劑除nacl山inni為國產分析純對rr為amesa產品， y乍jatp為北京亞輝生物醫學工程公司產品外，余者均為sipoa產品。
  3. For example, we have found the clustering of egfr ( epidermic growth factor receptor ) and tnfr ( tumor necrosis factor receptor ) and the activation of camp - pka - creb and jnk / sapk pathways after mnng treatment

    例如細胞表面受體如表皮生長因子受體、腫瘤壞死因子受體發生聚簇，細胞信號轉導通路camp kacgyb和jnk sapk被激活。
  4. They are pkc, pka, mek1 in erk pathway, mekk1 in sapk / jnk, p38 in p38 pathway, the three latter pathways all belong to the map kiiiase pathway. the inhibition of pkc decreases the proliferation after the il - 16 treatments, which hint its role in proliferation signal transduction

    結果表明，加入pkc的抑制劑，強烈抑制了所有濃度16處理下細胞的增殖，暗示pkc在u一16與cd4結合后，可能傳遞了增殖相關信號，它的存在是jllrk盯細胞的生長增殖必須的。
  5. Protein kinase a is camp - dependent kinase, one of the most important signal transduction pathways, plays a pivotal role in growth, differentiation, tumor occur, cell cycle control, etc. pka activators such as camp, 8 - br - camp or phosphodiesterase ( pde ) inhibitor isomethyl butyl xanthine ( imbx ) or purified pka catalytic subunit all can inhibit germinal vesicle breakdown ( gvbd ) and meiotic maturation in mouse oocytes, also in xenopus oocytes

    蛋白激酶a （ proteinkinasea ， pka ）是依賴于camp的絲蘇氨酸蛋白激酶，是重要的信號傳導途徑之一，廣泛參與許多生命過程，包括生長、分化、腫瘤發生、細胞凋亡、細胞周期調控等。以小鼠卵母細胞為實驗對象，給予pka激動劑camp 、 8 - br - camp或磷酸二酯酶抑制劑imbx （ isomethylbutylxanthine ）均可抑制小鼠卵母細胞的胚泡破裂及減數分裂成熟。
  6. Channels via a functionally associated pka in ca1 pyramidal neurons of rat hippocampus

    錐體神經元遲發性死亡中的作用，發現
  7. Pka agonist 8 - br - camp ( l0 # moi / l ) had no effect on lnmda and b ( 10 - ' momi ) suppression of nmda - evoked current

    即rp七amps也具有抑制inmda峰值和翻轉b對inmda快速抑制效應的作用。
  8. Quantum chemistry study of pka for norepinephrine in aqueous solution

    值的量子化學研究
  9. Pka, receptor tyrosine kinase ( trk ) and classical nuclear receptor of gc were not involved in the gc " s activation of mapks the second part studied the nuclear translocation of gc activated mapks, mainly p38 and jnk, with laser confocal microscopy. the results showed that : 1

    Gc激活的mapks的激活不需要pka酪氨酸激酶受體trk及經典gc核受體的參與第二部分是研究gc激活的mapks的核轉位，主要是p38和jnk ，用激光共聚焦顯微鏡觀察到以下結果： 1
  10. In this article, we microinjected camp ( as activator of pka ) and protein kinase inhibitor ( pki ) ( as inhibitor of pka ) into mouse 1 - cell stage fertilized eggs, the camp concentration, pka and mpf activaty were detected, also the cdc25c, cdc2 phosphorylated state and the concentration of ptyr15 for cdc2, cyclin b1. materials females of 4 - 5 week - old kuming mice and males of 8 week - old kuming mice were supplied from the department of laboratory animals, china medical university

    本實驗應用pka激動劑camp及抑制劑pki顯微注射入小鼠二一細胞期受精卵並觀察卵細胞m期形態學變化及pka對mpf活性的影響以及cdc25c ， cdcz電泳遷移率， cdcz的磷酸酪氨酸ptyrl及周期素b含量，為揭示pka在哺乳動物細胞周期調控機制，對生長、發育、癌變、死亡的研究提供理論依據。
  11. In xenopus embryonic extracts camp concentration and pka activity also oscillations accompany with the cell cycle, low in mitosis and increased during m / g1 transition, keep high until next mitosis, and the mechanism concern with the cdc25 phosphorylation state and cyclin b concentration. mouse fertilized egg is the most simple and natural model for cell cycle that near to human, but little is know about pka on mpf also pka on mitosis

    通過對非洲爪贍胚胎細胞周期的研究發現jka活性也隨細胞周期變化而波動，在m期出現時pka活性下降，而m間期轉換時pka活性達最大值，一直維持高值直到下一個m期出現，其對mpf活性調節與cdc25磷酸化狀態及周期素b表達有關。
  12. Owing to resonance stabilization of the conjugate base, an - hydrogen in an aldehyde is more acidic than a hydrogen atom in an alkane, with a typical pka of 17

    醛基是帶有極性的，氧原子是碳氧鍵中的負偶極，將碳原子的電子扯向氧原子。
  13. Free cyclin level is low for they quickly bind with cdc2, the total cyclin mainly exist in mprty ( pre - mpf ) ml to m2 process ; all the elements are set to g2 arrest concentration, then we set pka - > ipka rate = 0. 1 to simulate progesterone effect, ( it has been reported that progesterone can decrease the camp level, thus causes pka inactivation ) mpf activity rise at ml, falls at the inter phase between ml and m2, and then remains high at m2 arrest

    ： 22 nxm m dt 『 ? ? 「 ? 『民十cd 。 251 i ： vj rccjc25 pi然後，我們應用gepasi來進行這個模型的計算機模擬結果爪群卵成熟過程的模型模擬gz期阻滯，總的cyclinb的含量雖然升高，但是mpf保持在低活性狀態，隨著pka的失活， mpf活性有戲劇性的變化，它的活性在mi升高，在問期下降，然後又在mz期升高，最後停留在高活性的mz期。
  14. Gene cloning and expression of pka catalytic subunit and its activity in arabidopsis thaliana

    克隆和表達及鈣調素結合活性分析
  15. The model may be used not only to simulate the process, but also to provide explanations why the process is so ; here we give an explanation of such a process. we showed that pka increased the threshold 0 our model might be used to simulate and explain the normal oo - cyte maturation process, and next, we simulated several experiments and compare results observed in our simulation with those observed in experiments. quantitative models could be well used to simulate kinase activity changes in xenopus oocyte maturation

    模型可以用來模擬這樣的卵成熟的過程，也就說明了這個模型在一定程度上是符合卵成熟過程的真實情況的，但是，如果僅僅是模擬，發揮不出模型的真正作用，模型的作用是讓人們在模擬這樣的卵成熟過程的同時，通過這樣的一個模型工具深人的理解卵成熟的機制我們通過對模型進行分析發現： pka可以升高mpf激活的總的cyclinb閾值，從而使卵停留在gz期
  16. A mutant of pka phosphorylated sites ( mp ) was also checked. the result showed that each of them could bind to full length of raplgap by co - ip

    通過co ip方法，發現上述刪除體和突變體都能和全長rplgap形成二聚體。
  17. ( 3 ) in our study, atp weaken the activities of bkca channels. this effect could be inhibited and reversed by h - 89, which indicated the participation of pka

    通道的活動，而這種抑制作用可被p以特異性阻斷劑1 89翻轉，表明pka介導了atp對通道活動的抑制作用。
  18. It is even more interesting that the activation of some pathways, i. e., the activation of camp - pka - creb and clustering of cellular surface receptor egfr seem to be independent of dna damage, because these events can still occur in enucleated cells

    更值得注意的是這些有關信號轉導通路的激活有的並不依賴于細胞核中的dna損傷，因為在除去細胞核的細胞中有些細胞通路的激活仍可被誘發。
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