plga 中文意思是什麼

plga 解釋
聚乳酸聚乙醇酸共聚物
  1. This millirod system incorporates multiple components : a plga matrix ; excipient in free and complex forms ; drug in free, bound, and crystalline forms

    這個微囊系統包括多種成分： plga基質；單一和復合型賦形劑；游離、結合和結晶型藥物。
  2. Characteristics of mscs adhesion to polypeptides modified surface polymer plga - asp - peg

    對骨髓基質細胞黏附特性的影響
  3. There was no difference in other biologic characteristic of mscs between the two separation method, such as cell anchorage ratio and clone formation ratio. ( 2 ) plga film presented uniformity frame with no protuberance and fissure under scanning electron microscopy ( sem ). big aperture with smooth wall and average 400 m i n size running - through each other was observed in porous plga substrate, around the big aperture there were many round micropores about 5 m size. all of the structure were equal and uniform, which satisfied the further research work. ( 3 ) mscs adhesion at earlier time was promoted by biotiegenrafter 3h, cell number was ( 1. 5 0. 18 ) 105 in the plga film coated with biotiegen group, which was significantly higher than that in plga film group ( p < 0. 01 ) and higher than that in coverslip group ( p < 0. 05 ), which cell number was ( 1. 04 0. 21 ) 105. after 6h and 12h biotiegen could not promote cell adhesion, and cell proliferation and alkaline phosphatase ( alp ) activity were not promoted dramatically during 9 days. ( 4 ) cell adhesion was promoted by fibronectin or collagen type i

    G ） i型膠原、纖維粘連蛋白促進細胞增殖，細胞接種后3 、 6 、 gd三個檢測時間點，實驗組細胞均明顯高於對照組。與1型膠原相比，纖維粘連蛋白刺激作用更強。 ） i型膠原、纖維粘連蛋白尚能誘導mscs細胞向成骨細胞分化，不僅表達成骨細胞標志物ocn 、 alp 、 opnmrna ，而且堿性磷酸酶活性明顯增高，堿性磷酸酶及鈣結節7第四軍醫大學博士學位論文一染色均強陽性， i型膠原組mscs細胞堿性磷酸酶活性較fn組更高，有顯著性差異；同時，兔疫組化染色表明，經纖維粘連蛋白作用的mscs1型膠原表達陽性。
  4. Water - assisted formation of honeycomb microporous films starting from plga solution

    共聚物蜂窩狀多孔膜
  5. It was determined that the particle size of haloperidol - loaded plga / pla nanoparticles is effectively controlled by the amount of shear stress transferred from the energy source to the organic phase, which is strongly correlated to the following parameters : type of applied energy, aqueous phase volume, and polymer concentration in the organic solvent

    已經確定可通過對有機相的剪切力大小來有效控制氟哌啶醇plga / pla納米粒的粒徑，而這種剪切力大小與下列參數密切相關：所用能量類型，水相體積和有機溶劑中的聚合物濃度。
  6. Cell adhesion to surface of the substrate is essential to development of the anchorage - dependent cells. only after adhering to surface followed by spreading can cells develop and proliferate. most synthetic polymers used as orthopaedic matrix substitute present hydrophobicity, which may correlates to the low degree of cell attachment. modification with cell adhesion protein / peptides can be benificial to the cell adhesion on polymers and then affect the cell proliferation and differentiation. cell attachment to substrate is primarily mediated by integrins, a widely expressed family of heterodimeric surface receptors. most extrcellular matrix proteins such as fibronectin, osteopontin, collagen type i, bone sialoprotein and vitronectin contain an arg - gly - asp ( rgd ) sequence which is specific to the fixation of cell membrane receptors like integrin. the main aim of this research is to measure, assess adhesion, proliferation of rabbit marrow stromal cells ( mscs ) on the polymers coated by fibronectin, collagen type i or biotie gen, which includes : ( 1 ) biologic characteristics of rabbit mscs were observed by two types of separating method in primary culture. ( 2 ) adhesion, proliferation and differentiation of mscs cultured on polymers coated with biotiegen were assessed. ( 3 ) also, adhesion, proliferation and differentiation of mscs were assessed on plga film or porous plga substrates coated with fibronectin, or collagen type i respectively. ( 4 ) bone formation was observed on the porous plga substrates coated with collagen type i in vivo. this research aims to give new way to make novel synthetic bone with cell adhesion and high bone induction capabilities

    因此將這些蛋白包被、固定到材料表面，觀察骨組織工程種子細胞mscs細胞的粘附、生長特性是本研究的中心環節，並從以下方面進行探討： （ 1 ）採用不同原代細胞分離方法，研究其對mscs細胞的生物學特性影響。 （ 2 ）檢測基因勝肽膠對mscs細胞粘附、增殖及分化的影響。 （ 3 ）分別採用型膠原及纖維粘連蛋白（ fibronectin ， fn ）包被聚乙醇酸-乳酸共聚物（ poly （ 1actide - co - glycolide ） ， plga ）膜及多孔塊型plga材料，觀察細胞在單層或三維培養狀態下，型膠原及fn對mscs細胞粘附、增殖及向成骨細胞分化效應及能力。
  7. When optimized, the drug - loaded plga / pla nanoparticles contain as much as 2. 5 % haloperidol

    在最優條件下， plga / pla納米粒載藥量可高達2 . 5 %氟哌啶醇。
  8. Plga particles expand around nacl particles create the well - distributed foamy disc and plga / nacl particles ratio effects the porosity and open pore rate, the diameter of nacl particles determined the pore size

    支架的釋放性能可以在第7 28天高效維持，並且持續至第49天。
  9. Cell biocompatibility studies of plga tcp

    磷酸三鈣的細胞生物相容性研究
  10. This study focuses on mathematical modeling of drug release from plga cylindrical millirods

    這項研究集中在藥物從plga圓筒型微囊中釋放的數學模型。
  11. This level of understanding should quicken the pace of designing protocols for making new drug - plga nanoparticles

    這種理解能加快制定新載藥plga納米粒的設計方案。
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