post-translational cleavage 中文意思是什麼
post-translational cleavage
解釋
翻譯后裂解- post : n 1 （被指定的）地位，崗位；職位，職守。2 【軍事】哨所，站；哨兵警戒區；〈轉義〉哨兵，衛兵。3 基...
- translational : 翻譯的
- cleavage : n. 1. 劈開，劈裂；劈開處。2. 【生物學】卵裂；分裂；【礦物】解理，劈理。
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In vivo, the two functional forms of rat mapllc3 with apparent mobilities of 18 and 16kda, termed lc3 - i and lc3 - ii, separately, were produced by a series of post - translational modifications including a characteristic c - terminal cleavage after the conserved glyl20 residue and this cleavage is essential for the membrane association of the 16kda rat map1lc3 protein.,
其中18kda的map1lc3蛋白是微管相關蛋白1的輕鏈亞基，稱為lc3 - ；另一種16kda的map1lc3蛋白則是自噬體膜的必須組分，稱為lc3 - 。 lc3 -和lc3 -都是一系列翻譯后修飾的產物，其中特徵性的修飾是在保守gly120后發生的羧基端切割，此切割修飾對lc3 -定位於自噬體膜尤為重要。 -
In vivo, the two functional forms of rat map1lc3 with apparent mobilities of 18 and 16kb, termed lc3 - i and lc3 - ii, separately, were produced by a series of post - translational modifications including a characteristic c - terminal cleavage after the conserved gly120 residue and this cleavage was essential for the membrane association of the 16kd rat mapllc3 protein
Lc3 ?和lc3 ?都是一系列翻譯后修飾的產物，其中特徵性的修飾是在保守gly120后發生的羧基端切割，此切割修飾對lc3 -定位於自噬體膜尤為重要。我們研究發現在大鼠，小鼠和人中map1lc3主要以兩種型存在， lc3a型和lc3b型。 -
We found that there are two types of map1lc3 in rat, mouse and human, besides that, there is another type ( map1lc3c ) in human. we expressed all map1lc3 in hek293 cells respectively and found that the post translational modification of all map1lc3 is similar to yeast apg8 and rat map1lc3 identified except human lc3b. characteristic carboxyl cleavage occurred in conserved glycine of them
在hek293細胞中分別表達這三個物種中的所有的a型、 b型以及人map1lc3c分子，發現除了人的map1lc3b外其它同源物的修飾方式與已知的酵母apg8和大鼠的lc3修飾方式相類似，均發生了羧基端的切割反應而且羧基端保守的甘氨酸是它們發生翻譯后修飾的活性位點。
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