receptor activation 中文意思是什麼

receptor activation 解釋
受體活化
  • receptor : n. 【生物學】感受器;受體;【化學】接受器;受納體;【電學】感受器;接收器。
  1. Cell proliferation and ca2 - calmodulin dependent protein kinase activation mediated by ? 1a - and ? 1b - adrenergic receptor in hek293 cells

    65 .張坦陳鳳榮張幼怡。腎上腺素受體的生物進化。
  2. Comprehensive cellular responses was found in human amnion fl cells following exposure to low concentration of mnng, such as the lowering of dna replication fidelity resulted from alteration of dna polymerase profile ; activation of a lot of transcription factors, such as api, creb, nf - kb etc ; clustering of egfr ( epidermal growth factor receptor ) and tnfr ( tumor necrosis factor receptor ) and activation of camp - pka - creb and jnk / sapk signal pathways

    我們發現,低劑量mnng處理后的人羊膜fl細胞有廣泛的細胞反應,並有多個信號轉導通路的激活和基因表達的改變。例如dna復制保真度下降, dna聚合酶譜發生改變,應用報告基因技術和底物磷酸化檢出技術證明細胞一系列轉錄因子如ap1 、 creb 、 nf b等被激活,細胞表面受體如表皮生長因子受體、腫瘤壞死因子受體發生聚簇,細胞信號轉導通路camp - pka - creb和jnk sapk被激活。
  3. The degradation of i k b and dissociation from nf - k b complex are essential process for activation of nf - k b. there is no report about whether cck - 8 inhibits nf - k b activity through inhibiting lps - induced degradation of i k b. the present study was designed to observe the regulatory effect of cck - 8 on changes of immune functions induced by lps, the receptor mechanism and signal transduction mechanism involving mapk, stat3 and i k b at different levels including in vivo and in vitro, in order to study its immunomodulatory effect on reversing es and its molecular mechanisms

    Ikb的降解、並從w兒b復合物上解離是w4b激活的必需過程。 ccks是否通過抑制lps誘導的ikb降解,從而抑制nf幾b激活尚未見報道。本研究在整體、細胞及分子水平,觀察了ccke對lps引起的免疫功能改變的調節作用,研究了其受體機制及mapk 、 stat3和ikb的信號轉導機制,以探討cck七抗es時的免疫調節作用及其分子機制。
  4. For example, we have found the clustering of egfr ( epidermic growth factor receptor ) and tnfr ( tumor necrosis factor receptor ) and the activation of camp - pka - creb and jnk / sapk pathways after mnng treatment

    例如細胞表面受體如表皮生長因子受體、腫瘤壞死因子受體發生聚簇,細胞信號轉導通路camp kacgyb和jnk sapk被激活。
  5. Inositol 1, 4, 5 - trisphosphate receptor involved in the activation of calcineurin signaling pathway in myocardium

    三磷酸肌醇受體參與心肌鈣調神經磷酸酶信號通路的激活
  6. Receptor mechanisms underlying synaptic responses of motoneurons to the descending activation and afferent input in neonatal rat spinal cord in vitro

    離體脊髓運動神經元介導下行激活和外周傳入的受體機制
  7. Pka, receptor tyrosine kinase ( trk ) and classical nuclear receptor of gc were not involved in the gc " s activation of mapks the second part studied the nuclear translocation of gc activated mapks, mainly p38 and jnk, with laser confocal microscopy. the results showed that : 1

    Gc激活的mapks的激活不需要pka酪氨酸激酶受體trk及經典gc核受體的參與第二部分是研究gc激活的mapks的核轉位,主要是p38和jnk ,用激光共聚焦顯微鏡觀察到以下結果: 1
  8. This response was mediated by gi and subsequent activation of phospholipase c ( plc ), which triggered two pathways : protein kinase c ( pkc ) led to repulsion, and inositol 1, 4, 5 - triphosphate ( ip3 ) receptor activation led to attractive turning

    信號轉導機制的研究表明, sdf - 1和baclofen激活了生長錐表面的g蛋白耦聯受體,通過gi將信號傳遞給plc ,進而激活pkc和ip3信號通路。
  9. An array of regulatory proteins have been found, which inhibit the formation of central enzymes involved in early stages of the complement activation pathway. these include membrane cofactor protein ( mcp cd46 ), decay - accelerating factor protein ( daf cd5 5 ), complement receptor 1 ( cr1, cd35 ), as well as cd59, which inhibits formation of the membrane attack complex during later stages. these regulatory factors are widely expressed and abundant on many cells, and in fluids of reproductive system

    目前發現,機體多種細胞以及生殖系統的體液中表達和分泌豐富的補體調控蛋白,包括作用於補體活化早期階段的cd55 、 cd46 、 cd35和作用於補體活化終末階段的cd59 ,它們分別通過抑制補體活化過程中關鍵的c3 、 c5轉化酶和抑制形成膜攻擊單位,抵抗補體對自身組織細胞的攻擊。
  10. Effective activation of antigen - specific t cells not only requires the first signal transduction through t - cell receptor ( tcr ) binding with peptide - mhc complex on the antigen presenting cell ( apc ), but also needs the second signal, termed costimulation. costimulation critical to the degree and consequence of t cell activation is provided by interaction between soluble factors or cell - surface molecules on the t cell and on the apc

    而t細胞的活化除需要t細胞受體( tcr )與抗原呈遞細胞( antigenpresentingcell , apc )表面的抗原肽- mhc復合物結合所形成的第一信號外,還需要t細胞和apc表面的其它膜分子結合所提供的共刺激信號(亦稱第二信號或輔助刺激信號, costimulatorysignal )的參與。
  11. It suggests that the second ig - like domain of the trka receptors is critical for ngf binding and receptor activation

    表明i夕在介導ngf與腸沁、的功能結合過程中發揮著至關重要的作用。
  12. These findings suggest that c. chinensis extract may interact with cell surface membranes in a different way from ngf, and indirectly activate ngf receptor. consequently, c. chinensis extract shares the common pathway induced by ngf, leading to activation of specific gene required for the differentiation process

    這說明菟絲子提取物可能通過一種不同於ngf的方式與pc12細胞作用,間接地活化ngf受體;隨后通過與ngf相同的方式激活誘導細胞分化的相關基因,從而誘導pc12細胞分化。
  13. Ngf binding to trka receptors results in receptor dimerization and kinase activation. recent evidence supports that not all extracellular subdomains are responsible for receptor activation. structure based drug design for neurotrophic agonists with small molecular weight relies on knowledge of the interaction of neurotrophin with their receptors

    Trka在ngf作用下發生二聚化,使胞內域中酪氨酸激酶區激活,從而使trka中酪氨酸自磷酸化,並進一步激活胞內信號轉導通路,從而實現神經營養信號傳遞。
  14. Alterations in glycosylation have been proposed to participate in cell adhesion, receptor activation, cell differentiation and tissue morphogenesis. because the early embryo is composed of cells that must adhere to other embryonic cells, it seems likely that glycans modulating this adhesion would have been indispensable for early development. genetic elimination or partial abrogation of expression of some major classes of glycans, such as n - glycans, glycosphingolipids, hyaluronan and sialic acids, has been shown to be lethal during murine embryogenesis

    胚胎發育過程中伴隨著細胞表面糖鏈表達水平及結構的改變,研究表明這些改變參與介導了胚胎細胞之間的粘附聯系,因此,糖鏈對于胚胎正常發育是必須的,一些糖鏈結構(如n -連接糖鏈,糖鞘脂,透明質酸,唾液酸等)的表達缺失能導致小鼠死亡于胚胎的早期發育階段。
  15. In this paper, we review the recent research concerning the integrin activation and integrin signaling, as well as their cooperation with receptor protein tyrosine kinases

    本文綜述了整合蛋白的活化過程、信號轉導過程及其與生長因子受體信號通路相互關聯研究的最新進展。
  16. The study of in - situ construction of cytocompatible surface on pdl - la matrix via amphiphile - amino acid ( rgd ) hybrid self - segregation - the amphiphilic diblock copolymer, poly ( dl - lactide ) - poly ( ethylene oxide ) ( pla - peo ) copolymer, containing hydrophobic pla block and hydrophilic peo block was synthesized via coupling method in this dissertation. cell - adhesion - promoting amino acids and integrin receptor peptide rgd were then immobilized at the end of peo chain of pla - peo copolymer via hydroxyl group activation technique. the solvent blending and casting method was then used to obtain the amphiphile modified pdl - la membranes

    兩親共聚物-氨基酸( rgd )雜化體原位自修飾構建聚乳酸細胞相容性表面的研究一本論文首先設計併合成了一類含疏水聚乳酸( pla )鏈段和親水聚氧乙烯( peo )鏈段的兩親嵌段共聚物材料( pla - peo ) ,利用peo鏈端的活性官能團羥基固定了促細胞粘附的氨基酸及整合素配體多肽片段rgd 。
  17. Both spla 2 and ceramidehave been shown to inhibit bradykinin -, and pma - induced phospholipase d activation. these results indicated the existence of a subtle intertwined regulatory interaction between intracellular phosphoglycerol lipids and sphingolipids signaling pathways. in addition, we also found that spla can 2 down regulate theepidermal growth factor ( egf ) receptor activation

    此外,我們還發現分泌型磷脂酶a能下調表皮生長因子受體的活化,它能明顯的抑製表皮生長因子誘導2的受體自身磷酸化,並抑製表皮生長因子誘導的磷脂酶d活性和磷脂酶c - g的1酪氨酸磷酸化。
  18. The effect of peroxisome proliferator - activated receptor activation on metabolism and blood pressure in hypertensive rats with insulin resistance

    活化對胰島素抵抗合併高血壓大鼠代謝及血壓的影響
  19. However, this strategy lacks the ability of high - throughput screening. as the random screening approach requires a target molecule, it is essential to identify the subdomain of trka responsible for ngf binding and receptor activation

    傳統觀點認為酪氨酸蛋白激酶型受體由於有較大的膜外域,小分子化合物難以使其激活,也難模擬大分子的生物的效應。
  20. Further studies indicate that lipid rafts and caveolae are required only for igf - 1 receptor downstream signaling and not the activation of receptor

    而非特異性的脂質結合試劑, xylazine ,不影響脂肪細胞分化和克隆擴增。
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