ring substitution 中文意思是什麼
ring substitution
解釋
環上取代作用- ring : n 1 圈，環，輪；戒指，指環，耳環，鼻圈，鐲子（等）；【運】吊環。2 輪狀物；【植物；植物學】年輪；...
- substitution : n. 1. 代，代用，代替，更替，置換。2. 【化學】取代；【數學】代換；代入；【法律】預定繼承人；【語法】詞的代用。adj. -al ,-ary adj.
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The pocket accommodating the aromatic ring of phenylalanine is formed predominantly by hydrophobic side - chains, including those of ile10, ile13, prol50, leul75, leul79, phe209, ser211 and val221 ; whilst the amino group and carboxylate group of phenylalanine is coordinated by asp6, asp7, gln151 and ser180. the n - terminal region is found to be important to the function of arog. point mutation reveals that residue substitution of ilelo to ala10 leads to desensitization in the presence of 1 mm phenylalanine, simultaneously, exhibits a dramatic decrease in enzymatic activity
綜合前人的研究和本研究工作的實驗數據，得出以下結論： 1 ）在arog的反饋抑制位點供苯丙氨酸結合的疏水口袋由asp6 、 asp7 、 ile10 、 ile13 、 pro150 、 gln151 、 leu175 、 leu179 、 ser180 、 phe209 、 ser211和val221等12個氨基酸殘基構成； 2 ）苯丙氨酸結合的疏水口袋分為兩個區域，與苯丙氨酸的苯環發生疏水作用的區域由ile10 、 ile13 、 pro150 、 leu175 、 leu179 、 phe209和val221的側鏈構成，而asp6 、 asp7 、 gln151和ser180的側鏈構成了與苯丙氨酸的氨基和羧基相互作用的區域。 -
Mirtazapine was prepared by a seven - step reaction, namely nucleophilic ring - opening reaction, chlorination, cyclization, uncleophilic substitution, hydrolysis, reduction and cyclization from styrene oxide and n - methylethanolamine as the starting materials, with overall yield of 22. 6 %
摘要以環氧苯乙烯和n -甲基乙醇胺為起始原料，經親核開環、氯代和環合反應得到中間體1 -甲基3 -苯基哌嗪。
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