terminal residue 中文意思是什麼

terminal residue 解釋
末端殘基
  • terminal : adj 1 終端的，終點的，結尾的；極限的。2 定期的，每期[季]的；每學期的，學期終[末]的。3 期終的；末...
  • residue : n. 殘余，殘渣，餘款；【林業】廢材，木屑；【法律】剩餘遺產，余產；【化學】殘基；濾渣；余渣，殘余物；【數學】殘數，留數，余數。 for the residue 至於其餘；說到其他。
  1. In vivo, the two functional forms of rat mapllc3 with apparent mobilities of 18 and 16kda, termed lc3 - i and lc3 - ii, separately, were produced by a series of post - translational modifications including a characteristic c - terminal cleavage after the conserved glyl20 residue and this cleavage is essential for the membrane association of the 16kda rat map1lc3 protein.,

    其中18kda的map1lc3蛋白是微管相關蛋白1的輕鏈亞基，稱為lc3 - ；另一種16kda的map1lc3蛋白則是自噬體膜的必須組分，稱為lc3 - 。 lc3 -和lc3 -都是一系列翻譯后修飾的產物，其中特徵性的修飾是在保守gly120后發生的羧基端切割，此切割修飾對lc3 -定位於自噬體膜尤為重要。
  2. In vivo, the two functional forms of rat map1lc3 with apparent mobilities of 18 and 16kb, termed lc3 - i and lc3 - ii, separately, were produced by a series of post - translational modifications including a characteristic c - terminal cleavage after the conserved gly120 residue and this cleavage was essential for the membrane association of the 16kd rat mapllc3 protein

    Lc3 ?和lc3 ?都是一系列翻譯后修飾的產物，其中特徵性的修飾是在保守gly120后發生的羧基端切割，此切割修飾對lc3 -定位於自噬體膜尤為重要。我們研究發現在大鼠，小鼠和人中map1lc3主要以兩種型存在， lc3a型和lc3b型。
  3. Carboxyl terminal residue

    羧基末端殘基
  4. The pocket accommodating the aromatic ring of phenylalanine is formed predominantly by hydrophobic side - chains, including those of ile10, ile13, prol50, leul75, leul79, phe209, ser211 and val221 ; whilst the amino group and carboxylate group of phenylalanine is coordinated by asp6, asp7, gln151 and ser180. the n - terminal region is found to be important to the function of arog. point mutation reveals that residue substitution of ilelo to ala10 leads to desensitization in the presence of 1 mm phenylalanine, simultaneously, exhibits a dramatic decrease in enzymatic activity

    綜合前人的研究和本研究工作的實驗數據，得出以下結論： 1 ）在arog的反饋抑制位點供苯丙氨酸結合的疏水口袋由asp6 、 asp7 、 ile10 、 ile13 、 pro150 、 gln151 、 leu175 、 leu179 、 ser180 、 phe209 、 ser211和val221等12個氨基酸殘基構成； 2 ）苯丙氨酸結合的疏水口袋分為兩個區域，與苯丙氨酸的苯環發生疏水作用的區域由ile10 、 ile13 、 pro150 、 leu175 、 leu179 、 phe209和val221的側鏈構成，而asp6 、 asp7 、 gln151和ser180的側鏈構成了與苯丙氨酸的氨基和羧基相互作用的區域。
  5. These results unambiguously demonstrate that a single amino acid residue substitution is sufficient to generate a phenylalanine - insensitive form of arog. furthermore, the mutant a ( l - 15 ) lacking the first fifteen n - terminal amino acid residues exhibits no sensitivity toward phenylalanine in a range of 0 ~ 1 mm phenylalanine

    這些結果揭示: 1 ） n一末端在反饋抑制機理中具有重要作用; 2 ） n一末端的缺失使得ar0g緊密二聚體結構解聚，導致四級結構破壞。
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