核受體 的英文怎麼說
中文拼音 [héshòutǐ]
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Detection of fibroblast growth factor receptor 3 gene mutation at nucleotide 1138 site in congenital achondroplasia patients
先天性軟骨發育不全成纖維細胞生長因子
受體3基因1138位
核苷酸點突變的檢測
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We hope that our study will provide us with more comprehensive knowledge of the mechanisms of immune regulation and the roles that dc and complement play in innate and acquired immunity, as well as to lay a foundation for further exploration of the roles dc play in antigen - specific immune responses and immune tolerance from a new perspective. part i expression of complement receptors and complement - associated molecules on dendritic cells derived from distinct - origin at different stages of development two subsets of dendritic cells were generated from precursor cells isolated by means of magnetic cell separation system
曰補
體受體及其相關分子在modc上的表達不同分化階段的單
核細胞衍生性dc ( monocytes一deriveddc , modc )的誘導:將新鮮分離的單
核細胞mo ,在含有gm一csf和工l一4培養
體系中誘導5一7d ,即分化為未成熟modc ;對培養至sd的未成熟modc ,用tnfa刺激zd ,即分化為成熟modc ;此時再用lps刺激24h ,即為活化的modc 。
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Expression of leptin receptor in the cerebral amygdala of starved rats
饑餓大鼠腦杏仁
核中瘦素
受體的表達
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Blocking of ampa receptors in the central amygdaloid nucleus modulates the parabrachial nucleus taste responses in rats
受體對臂旁
核味覺反應的影響
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Aryl hydrocarbon receptor nuclear translocator, arnt
芳香烴
受體核轉位蛋白
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A large number of neurons with nig - li were seen in the anterior olfactory nuclei, accumbens nucleus, septal area, 09600045, 39970377, 39570109 ) 9 ventral pallidum, pallidum, caudate putamen, nucleus of the stria terminalis, anterior hypothalamic area, tuber cinereum area, lateral hypothalamic area, perifornical nucleus, supraoptic nucleus, arcuate nucleus, mammillar nuclei, substatia nigra, ventral tegmental area, retrorubral area, superior and inferior colliculus, periaqueductal gray, nucleus of the solitary tract, and superficial layers of the medullary and spinal dorsal horns
大量nk3
受體樣免疫反應陽性神經元出現於前嗅
核、伏隔
核、隔區、腹側蒼白球、蒼白球、尾殼
核、終紋床
核、下丘腦前區、下丘腦結節區、下丘腦外側區、穹隆周區、視上
核、弓狀
核、乳頭
體、黑質、腹側被蓋區、紅
核后區、上丘和下丘、導水管周圍灰質、孤束
核、及延髓和脊髓背角淺層。
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Chemotaxis mediated by chemokine receptors, such as cxcr4, play a key role in lymphocyte homing and hematopoiesis as well as in breast cancer metastasis. we have previously demonstrated that ? - arrestin2 functions to attenuate cxcr4 - meidated g protein activation and to enhance cxcr4 internalization. here we further show that expression of ( - arrestin2 in both hela and hek293 cells significantly enhanced the chemotactic efficacy of stromal - cell derived factor 1 ( ( sdf - 1 ( ), the specific agonist of cxcr4
- arrestin2是趨化因子
受體的一種重要的調節蛋白,本研究工作發現在hek - 293或hela細胞中升高- arrestin2的表達水平會顯著增強cxcr4介導的趨化作用,反之當- arrestin2的表達被它的反義
核苷酸或rnai所抑制, cxcr4介導的趨化作用則被明顯抑制。
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We focused on the following aspects ; 1 ) we first assayed the expression of complement receptors and complement - associated molecules on distinct subsets of dendritic cells during their development in order to understand the physical basis of the sensitivity of dendritic cells to complement and its split products ; we next studied the effects of complement activation on the survival of dendritic cells during their development ; and finally examined the effects of the whole complement system, focusing on the ability of one of the split products of complement activation, c5a, and its first subcomponent - c1q, to influence chemotaxis of dendritic cells, as well as allo - t cell stimulatory activity of dc
我們通過免疫磁珠分離了兩種人dc前
體,即髓系來源的單
核細胞( monocytes , mo )和淋巴系來源的漿細胞樣dc ( plasmaeytoiddendriticeells , pdc ) ,對這兩個不同dc亞群進行
體外誘導培養,使其處于不同的分化發育階段,然後檢測了其表達補
體受體一cd35 ( cri ) 、 cd21 ( crz ) 、 cdilb ( cr3 ) 、 cdlle ( cr4 ) ,補
體調控蛋白一cd46 、 cd55 、以及部分補
體片斷分子
受體一c3ar 、 csar 、 clqrp的水平。
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The syncytiotrophoblast and cytotrophoblast cell of human placenta showed 5 - htia receptor and s - htjreceptor immunoreactivity, positive substance was located in cytoplasm with negative nuclei. 2
人胎盤絨毛滋養層細胞呈現5 - ht
受體和5 - ht _ 3
受體免疫反應性,陽性物質分佈於胞質,胞
核為陰性: 2
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Reconstruction of mouse embryos with chemically enucleated oocytes
化學去
核卵母細胞為
受體的小鼠
體細胞
核移植
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Translocation from endocytic compartments to the cytosol is the essential and rate - limiting step in the intoxication process of most toxins such as ricin, diphtheria toxin, shiga toxin and pseudomonas exotoxin ( pe ). a number of these toxins are transported to trans - golgi network ( tgn ), and in many cases such transport to the tgn is required for the translocation and cytotoxicity. in deed, 5 % of the ricin endocytosed by cells has been shown to reach the tgn
蓖麻毒素進入細胞的機理不甚明了,一般認為是rtb先與細胞膜
受體結合,主要經過
受體介導的內吞作用進入吞噬
體,然後沿著內
體、高爾基
體、內質網等逆向分泌途徑,有序地運輸到內質網,最後從內質網轉位進入細胞漿,在胞漿內攻擊
核糖
體,從而抑制蛋白質的合成,導致細胞死亡。
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Within 2h isolation from the follicle 100 % of oocytes underwent germinal vesicle breakdown and both the nucleolus and the nuclear envelope disappeared. after culturing for 6 h, prometaphase occurred in 90 % oocytes
本研究旨在探索一種嶄新的、化學試劑誘導去
核卵母細胞為
核受體的、無透明帶的、手工
體細胞
核移植方法。
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Pka, receptor tyrosine kinase ( trk ) and classical nuclear receptor of gc were not involved in the gc " s activation of mapks the second part studied the nuclear translocation of gc activated mapks, mainly p38 and jnk, with laser confocal microscopy. the results showed that : 1
Gc激活的mapks的激活不需要pka酪氨酸激酶
受體trk及經典gc
核受體的參與第二部分是研究gc激活的mapks的
核轉位,主要是p38和jnk ,用激光共聚焦顯微鏡觀察到以下結果: 1
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To search proteins that associate with the mouse mint protein and regulate notch signaling in nuclei, and to study the function and mechanism of mint - mediated transcription repression, yeast two - hybrid assay was used to screen proteins that interact with a fragment of mint ( f5, amino acids 2226 - 2959 ). from 4x106 yeast clones transformed with the bait plasmid and a cdna library of 9 dpc mouse embryo, fifty - one were positive for nutritional screening and p - galactosidase assay. restriction digestion identified 10 independent positive clones and these were analyzed by dna sequencing these clones represent 3 correctly fused cdna fragments, which are mint, alpha a - crystallin - binding protein i ( alphaa - crybpl ), and nuclear receptor co - repressor 1 ( n - corl ), respectively
鑒于mwt基因編碼區較長,共有10799個堿基,故此我們將mint分為六段,分別命名為fi一f6 ,本研究以其中的f5 ( 222e959 )和f6 ( 296s576 )片段為研究對象,將h者分別插入pgb盯7載
體中,結果顯示: mintfs可與
核受體輔助抑制因子1階cori ) , o晶狀
體蛋白結合蛋白1hlphatcrybp入及mw加互作用,而f6可與igm的重鏈恆定區、泛素結合酶2l6和一個未知功能的新的蛋白基因進行結合。
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Estrogen through binding specific estrogen department of physiology 7 receptor ( er ) in nucleus, functions like a nucleus transcription factor and modulates expression of some genes. it has been found that there exist two subtypes of er. there are a and p subunits which are different in their distribution, density and mediated action
雌激素調節神經系統功能往往通過雌激素
受體( estrogenreceptor , er )蛋白介導。 er屬于類固醇
受體超家族的
核受體,具a 、 p兩種亞型,此二者在各種組織分佈及密度泅異。
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Estrogen receptor ( er ), an important transcription factor belonging to the nuclear receptor superfamily, plays a key role in reproductive, cardiovascular and central nervous systems and bone tissue
摘要雌激素
受體屬于
核受體超家族成員,是一類重要的
核轉錄因子,它在生殖系統、骨組織、心血管和中樞神經系統中發揮著重要的生理作用,是治療骨質疏鬆和乳腺癌的重要藥物作用靶標。
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In addition to the classical genomic pathway through nucleus receptors, estrogen can cause to produce some cellular rapid membrane - mediated effects through nongenomic pathway
Er具
核、膜雙重分佈特徵。雌激素的作用通過經典的
核受體通路和膜
受體通路來完成。
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There are a and 3 subunits of estrogen receptor ( er ) subtypes. they are different in their distribution, density and mediated action. er can be expressed in nucleus or in cellular membrane
雌激素
受體( er )屬于類固醇
受體超家族的
核受體,具有a和日兩種亞型,此二者在各種組織分佈及密度各異。
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Peroxisome proliferator - activated receptors ( ppars ) are a family of nuclear hormone receptors. ppar superfamily consists of three members : a, 5 and y
過氧化物酶
體增殖因子活化
受體( peroxisomeproliferator - activatedreceptors , ppars )是配
體依賴的轉錄因子的
核受體超家族成員,由ppar 、 ppar和ppar三個成員組成。
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The following research areas will be involved in the project : ( 1 ) mechanism of hereditic factors and its function in chinese type 2 diabetes ; ( 2 ) metabolomics on the cell stress and its nutrition intervention in the type 2 diabetes ; ( 3 ) mechanisms of metabolic nuclear receptors in the process of insulin resistance and type 2 diabetes onset ; ( 4 ) roles of signal transduction molecules, lipid metabolic disorder to insulin resistance ; ( 5 ) type 2 diabetes development and role of pathological changes of blood vessels ; ( 6 ) abnormal insulin secretion, apoptosis and type 2 diabetes ; ( 7 ) function of molecular network of type 2 diabetes progression
本項目擬開展以下研究工作: ( 1 )中國人2型糖尿病發生過程中遺傳因素的發現及其作用機制; ( 2 )細胞應激在中國人2型糖尿病發生過程中的作用機制及其營養干預的代謝組學; ( 3 )代謝性核受體在胰島素抵抗和2型糖尿病發病中的作用機制; ( 4 )細胞信號轉導分子、脂代謝紊亂與胰島素抵抗的關系; ( 5 ) 2型糖尿病發展過程與血管病變; ( 6 )胰島素分泌異常、細胞凋亡與2型糖尿病; ( 7 ) 2型糖尿病發生過程中的分子網路與作用機制。