肝結合作用 的英文怎麼說
中文拼音 [gānjiēgězuòyòng]
肝結合作用
英文
liver conjugation- 肝 : 名詞(人和高等動物的消化器官之一) liver
- 結 : 結動詞(長出果實或種子) bear (fruit); form (seed)
- 合 : 合量詞(容量單位) ge, a unit of dry measure for grain (=1 decilitre)
- 用 : Ⅰ動詞1 (使用) use; employ; apply 2 (多用於否定: 需要) need 3 (敬辭: 吃; 喝) eat; drink Ⅱ名...
- 結合 : 1 (發生密切聯系; 聯合) combine; unite; integrate; link; binding; coalition; cohesion; connectio...
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Using cd, cu, zn and cr as experimental toxicants and crucian as experimental creature, we employed the environmental biotechniques ( flame atomic absorption spectrophotometry, the method of improved pyrogallol autoxidation and electron microscopy ) to study the acute toxicity and secure concentrations of heavy metals to crucian ; the accumulation and distribution of mixed heavy metals to fingling crucian ; the activities of superoxide dismutase ( sod ) of gill and liver tissues and the hispathological and ultrastructural change of superfine structure of liver and kidney of crucian after cadmium exposure. through which, we intended to fully and systemically study the toxic influence of heavy metals to fish, and preliminarily discuss the influence of heavy metals pollution to the diversified level of fish such as individual, organ, tissue, cell and molecule. thus we tried to provide scientific evidence to establish preventative management measures, avoid and relieve the harm of heavy metals pollution to aquicolous ecosystem in time
隨后以這幾種重金屬作為實驗毒物,以鯽魚為實驗動物,應用環境生物技術、火焰原子吸收分光光度法、鄰苯三酚自氧化法、透射電鏡等技術研究了重金屬cu 、 zn 、 cd和cr對鯽魚的急性毒性及其安全濃度評價、混合重金屬在鯽魚幼體組織內的積累和分佈、 cd對鯽魚鰓和肝臟中sod活性的影響、 cd對鯽魚肝細胞和腎細胞超微結構的影響等,全面和系統地研究了水環境中重金屬暴露對魚類的毒性影響,初步探討了重金屬污染對魚類的個體? ?器官? ?組織? ?細胞? ?分子等各水平層次的影響,為制定漁業生產上預防性的管理措施提供科學依據,及時避免或減輕重金屬污染對水生生態系統造成的損害。Containing privet essence, along with the heat of hot spring, it features favorable effect on curing liver and kidney deficiency, lumbar debility, dizziness, tinnitus, white hair and poor vision
溫泉水中加入女貞子藥包,結合泉水的熱力作用,對肝腎陰虛、腰膝酸軟、頭暈、耳鳴、須發早白、目暗不明有一定療效。The main study in this paper included as follows : the content and distribution of heavy metals in sediments and benthic organisms from the sewage stream in guangzhou city ; the acute toxicity and joint toxicity of mercury and selenium to swordtail fish ( xiphophorus helleri ) ; the damage of mercury to the indexes of antioxidant system in the gills and livers in swordtail ( including the measurement of the activities of total antioxidative capacity [ t ~ aoc ], superoxide dismutase [ sod ], glutathione peroxidase [ gsh - px ] and the concentration of malondiald - ehyde [ mda ] ) and the relief effects of selenium on it, as well as the physiological damage of mercury on the tissues, namely : the antagonistic effect of na + - k + ~ atpase activity on the tissues between selenite and mercury, and the ultrastructural damage under the exposure of mercury
研究內容主要有:廣州市河涌沉積物及底棲生物體內重金屬含量及評價;汞和硒對劍尾魚的急性毒性和聯合毒性及安全濃度的評價;汞對劍尾魚鰓和肝臟中抗氧化系統的毒性,包括對總抗氧化能力、超氧化物歧化酶、谷胱甘肽過氧化物酶活力及丙二醛含量的測定及硒對其保護作用;汞對劍尾魚組織生理毒性即:汞對na ~ + - k ~ + atpase活力的影響及硒的保護作用和汞和對劍尾魚組織超微結構的損傷等。以高氯酸?硝酸消化法和火焰原子吸收分光光度法測定了廣州市河涌沉積物和底棲生物中重金屬含量。Exploring the possible mechanisms is an important content of bioinorganic chemistry and ecotoxicology, which has signality in modifying contamination effect to animals. this thesis studies on the chemical speciation of mercury and selenium in dolphin livers, sub - chronic toxic effect of wistar rats of sodium selenite and mercuric chloride and investigates the antagonism mechanism from there aspects : 1. redistribution of mercury in the presence of selenium, 2
本文以海豚肝臟為對象,研究其積累的高濃度汞硒化合物的化學形態和結構,並結合動物實驗的研究,從汞硒相互作用的總體生物學表現,汞硒在動物體內分佈變化和結合形態的變化以及汞硒化合物的結構等方面探討兩元素毒性拮抗作用機理。Knowledge of distribution and regulation of ugts remains limited. liver microsomes is a frequently used enzyme source in in vitro study of glucuronidation, but it has the following deficient respects : 1. liver microsome is a mixture of various enzymes, and therefore the results from microsome cannot represent the function of a individual isozyme
關于ugts的組織分佈和調節這方面的知識還不多,過去常採用肝微粒體進行研究,但有以下缺陷: u )肝微粒體是多種藥酶沮合的復雜體系,因而實驗結果難以區分是一種同工醇的作用Five analogues and five segments were designed and synthesized by using solid phase synthesis method according to separated papaver somniferum pollen tridecapeptide with antitumor activities as leading peptide. their primary secondary structures in solution were determined by cd spectra and their inhibitive activities to human liver and mammary gland cancer cells were assayed by mtt method. the relationship of structure - activity was studied and discussed
罌粟花粉十三肽對人肝癌和人乳腺癌腫瘤細胞具有明顯的抑制作用,以其為先導化合物,設計併合成了5個類似物和5個片段,結合cd譜測定的二級結構及它們對人肝癌和人乳腺癌腫瘤細胞的抑制作用測定結果,研究並討論了該肽結構與抗腫瘤活性的關系After adding culture mediem of stably transfected jurkat cells to hepatocarcinoma cells, the binding specificity of the scfvs with hbsag was further confirmed by observation by fluorescence microscope, indirect immunofluorescence and flow cytometer analysis. prokaryotic expression plasmids ptat - ha - scfvs were successfully constructed
建系細胞培養上清與肝癌細胞作用后,經熒光顯微鏡觀察、間接免疫熒光及流式細胞儀檢測進一步確定表達的scfv融合蛋白具有與hbsag特異性結合的活性。For further observation the influence of some polysaccharides including free heparin, lmw heparin, cs - a, cs - c, ha, dxs, fucoidan and carrageenan family on the interaction of heparin with ifn -, 1. 5 ng ifn - y was preincubated at 37 for 30 mins in the presence and absence of different concentration of these polysaccharides before addition to coated well
16拜g / ml ) 。結論}浙江大學碩士學位論文多糖與工fn一y的結合是一個復雜的過程, el工sa是一個簡單、靈敏的體外研究蛋白與多糖相互作用的方法,能夠在納克水平檢測到工fn一y與肝素的結合。Hla - g1, which is a newly defined non - classical hla class i molecule, plays an important role in mediating immunotolerance and protecting embryo and even some kinds of tumors from nk cells attacking. the full - length coding sequences containing cdna of hla - g1 were cloned from placenta, monocytes and liver cancer tissue of chinese donors. sequence analysis reveals that it is a highly conserved human gene with only two amino acid mutation sites compared to foreign nationality. its truncated form was overexpressed in
從中國人外周血單個核細胞胎盤組織和肝癌組織等樣品中克隆了包含完整hla - g1讀框的cdna與國外同行獲得的該基因及其蛋白質序列比較分析表明,該基因雖然有著細微的種族特異性,但高度保守並獲得了它的截斷型重組蛋白,根據蛋白一級結構和同源比較方法,模建了它及其與特異性受體kir2dl4形成復合體的空間結構模擬,預測了它們之間相互作用的特徵。The pharmacokinetic profile of lev closely approximates the ideal characteristics expected of an antiepileptic drug, with good bioavailability, linear and time - invariant kinetics, minimal protein binding, and least metabolism
左乙拉西坦幾乎具備了較好的抗癲癇藥物的所有藥動學特性:生物利用度高、線性曲線、低蛋白結合率、無肝酶誘導作用。Bsp ( boyine seminal plasma ) protein is the cardinal protein in bovine sperm, which can combine with choline or phosphycholine and then adhere to the surface of sperm to promote the sperm capacitation induced by heparin and high density lipoproteins ( hdl ). moreover, bsp protein can combine with heterogeneous collagen, fibrinogen, heparin, calmoduline, igf - ii and apoa - i. bsp can also inhibit the migration of cholesterol on the sperm membrane
前言bsp ( bovineseminalplasma )蛋白是牛精漿中的主要蛋白質, bsp蛋白可以與膽堿或磷脂膽堿結合,黏附於精子表面,可促進由肝素、 hdl等誘導的獲能過程,另外bsp蛋白與不同來源的膠原、纖維蛋白原、肝素、鈣調蛋白、 igf - 、 apoa -等結合, bsp蛋白還可抑制精子胞膜上的膽固醇遷移,這些都暗示了bsp蛋白在精子胞膜的脂類代謝及調節精子的獲能以及頂體反應方面發揮重要作用。The results showed that the interaction between selenium and mercury in rats mostly is the antagonism on the both acute toxicity tests and sub - chronic ones. liver, kidney, gland, heart, spleen, lungs, stomach and testis of rats are the target organs of mercury, selenium and their joint poison. and liver, kidney and spleen are three most important target organs
研究結果表明,大鼠體內硒與汞的急性和亞慢性相互作用主要表現為拮抗作用;大鼠肝臟、腎臟、胸腺、心臟、脾、肺、胃和睪丸等組織器官都是硒、汞及其聯合毒物的靶器官,其中肝臟、腎臟、脾臟是三個主要靶器官;肝臟中汞與硒的含量呈高度正相關,腎臟中汞與硒的含量呈負相關,但相關性不甚好。In order to further investigate the role of axudl in human tumor carcinogenesis and the potential association between the axudl gene expression status and the stimulation of transforming growth factor beta in human cancers, the present study was performed in three aspects as follows : ( 1 ) cloning full length enconding region cdna of axudl and construction of eukaryotic vector that expression the fusion protein of axud1 and influenza virus hemagglutin ha epitope tag ; ( 2 ) exploring the time and dose effects of tgf - 1 on the expression - of axudl gene in hepg2 hepatoma cells and spc - a1 lung carcinomas cells, and studying the effects of overexpression of axud1 on the expression of cell cycle and apoptosis related protein in hepg2 hepatoma cells ; ( 3 ) construction and expression of human axudl in e. coli m15. the following main results and conclusions can be obtained from the present study : 1. the full length ecnoding region of human axudl cdna from human peripheral blood lymphocytes was successfully cloned using one step rt - pcr method, and constructed into a eukaryotic expression vector which can be expressed a ha - axud1 fusion protein with axud1 and influenza virus hemagglutin ha epitope tag. the recombinant plasmid was identified by polymerase chain reaction, restriction endonuclease maping and sequencing, this expression vector might be instrumental to further study the function of axud1 protein in tumor cells
為了進一步研究axud1在人類腫瘤發生中的作用及axud1基因的表達狀況與tgf -介導的信號通路的關系,本實驗研究分為三個部分: ( 1 ) axud1基因cdna全長編碼區的克隆和ha表位標記的axud1基因表達載體的構建; ( 2 )探討肝癌細胞hepg2和肺腺癌spc - a1細胞中tgf - 1誘導的axud1基因表達的時間、劑量效應以及誘導表達的可能機理,並研究axud1的過表達對細胞周期和細胞凋亡相關蛋白表達的影響; ( 3 ) axud1原核表達載體的構建及其在大腸桿菌中的表達。本實驗的主要結果和結論如下: 1利用一步法rt - pcr成功地從人類外周血淋巴細胞中克隆出axud1基因編碼區cdna ,並將其構建入真核表達載體中,編碼的ha - axud1融合蛋白帶有流感病毒凝血素ha的表位標記肽段。The dna electrochemical sensor was prepared by self - assembling the designed hepatitis b virus dna specific probe on the surface of au electrode together with hoechst 33258 as electro - active indicator
利用自組裝單分子膜法,將人工合成的乙肝病毒單鏈dna片斷作為特異性探針固定在金電極表面,結合電活性指示劑hoechst33258構成dna電化學傳感器。In addition, the display of repertoires of antibody fragments on the surface of filamentous bacteriophages offers a new way of making antibodies with predefined binding specificities
高親和的抗乙肝病毒表面抗原pres1 ( 20 - 47 )抗體具有封閉hbv的作用。噬菌體展示技術提供了獲得結合特異表位抗體的新途徑。Results : scuteliaria and active ingredients have the antiviral effect on influenza virus, respiratory syncytial virus, sars coronavirus, hepatitis b virus, hepatitis c virus, human immunodeficiency virus, herpes simplex virus, human cytomegalo virus, coxsackie virus, porcine respiratory and reproductive syndrome virus
結果:總結了黃芩具有抗流感病毒、呼吸道合胞體病毒、 sars冠狀病毒、乙型肝炎病毒、丙型肝炎病毒、人類免疫缺陷病毒、單純皰疹病毒、人巨細胞病毒、柯薩奇病毒及豬生殖和呼吸系統綜合征病毒等作用。The gene cloning and sequence analysis of senv - d and senv - h isolated from china according to the published nucleotide sequences of sen viruses, specific primers were designed and synthesized. from the serum of two chinese patients with non - a - e hepatitis, one senv - d isolate named senv - d - bj1 spanning the complete coding region was amplified by semi - nested pcr, another isolate named senv - d - bj2 spanning the partial coding region ( including orf1 and orf2 ) was amplified too. from one blood donor serum, two senv - h isolates named senv - h12 - 1 and senv - h 12 - 2 spanning the complete coding region were amplified by nested pcr respectively
Sen病毒d和h亞型中國分離株的克隆及序列分析我們在前期工作的基礎上,結合已發表的文章及基因序列,針對senv - d和senv - h基因組設計特異性引物,利用套式pcr技術從兩例non - a - e肝炎患者血清中分段克隆得到了一個senv - d亞型分離株( senv - d - bj1 )的全部編碼區基因序列,還得到了一個senv - d亞型分離株( senv - d - bj2 )的大部分編碼區基因序列(包括orf1和orf2 ) ;從一例健康人血清中分段克隆得到了兩個senv - h亞型分離株( senv - h12 - 1和senv - h12 - 2 )的全部編碼區基因序列。Heparin is known to bind and modulate the activity of various proteins, including cell growth factors, cytokines, angiogenic factors, complement components, adhesion molecules, heparin exerts its activities via interaction with some proteins. potent anticoagulant activity of heparin by the interaction with antithrombin iii is extensively used in medicine
肝素能夠與許多蛋白質結合併調節蛋白活性,包括細胞因子、生長因子、趨化因子、抗血管生成因子、粘附分子和補體成分等,肝素通過與蛋白相互作用發揮其生物學活性。Conclusion the new synthesis benzene nitrogen mustard glucoside derivate can inhibit the growth of 7721 hepatumor cells and induce the apoptosis which is the one of the main mechanisms of antitumour
結論新合成的葡萄糖苯氮芥衍生物能明顯抑制肝癌細胞的生長,誘導細胞凋亡是其抗腫瘤作用的主要機制之一。分享友人