腫瘤抗原 的英文怎麼說
中文拼音 [zhǒngliúkàngyuán]
腫瘤抗原
英文
t antigen-
Common ground is told, the immune system that aids is human body is destroyed by aids virus, make human body lost counteractive ability to all sorts of pathogen of minatory life, produce a variety of infection or tumor thereby, cause a kind of of death serious infection finally
通俗地講，艾滋病就是人體的免疫系統被艾滋病病毒破壞，使人體對威脅生命的各種病原體喪失了反抗能力，從而發生多種感染或腫瘤，最後導致死亡的一種嚴重傳染病。[ conclusion ] taken together, these data suggested that two peptides gwyydal and vasavfysalve were effective mimickers of vegf and these peptides maybe potent inhibitors of kdr and offer a hope for the construction of tumor vaccine
而且該模擬抗原表位可能與huvec上表達的vegf受體結合，從而抑制了vegf的促huvec生長作用。這為進一步定位vegf抗原表位，研究vegf受體結合抑制肽，設計腫瘤疫苗提供了有力的基礎。Antibacteral peptide ( abp ) existing in the biosphere with the biotic activity is a kind of little peptide and has the action of antibacteria commonly and even can resist some protozoa, virus and tumour cells. the antibacteral peptide has become one of the hot spots of foreign and domestic scholars " investigavitions who gave more and more favors to it as its no ill effect
抗菌肽（ antibacteralpeptides ， abp ） ，是生物界中廣泛存在的一類生物活性小肽，一般具有抗細菌或真菌作用，有些還具有抗原蟲、病毒或腫瘤細胞的功能，且無毒副作用，倍受國內外學者的青睞，已成為國內外學者的研究熱點。Many cucurbitaceae plants were known to he chinese medicine herbs and contain ribosome - inactivating proteins ( rip ), a group of toxic proteins that have been proposed and demonstrated to play potential use as toxins in the therapy of a variety of human tumors and viruses including hiv
核糖體失活蛋白（ ribosome - inactivatingproteins ， rip ）具有抗腫瘤和抗病毒等醫用價值，以及抗植物病毒和病原真菌等農用價值。它是一種多活性的物質，不同rip具有各自獨特的功能，其潛在活性還在不斷發現之中。The progress in research of swainsonine immunogenicity and anticancer - activity
苦馬豆素的免疫原性及抗腫瘤研究進展Cea gene was transferred into human dcs, and specific anti - cancer effecs induced by the vaccine was observed. this test is part of my tutor ' s. hang you - tian has observed the induction of crcinembryonic antigen ( cea ) - specific cytotoxic t - lymphocyte responses in vitro when he transfected dcs with pcdna3 - cea, and has observed the immunity effects of the dcs ( pcea ) inoculateing against to ct 26 ( hcea + ) loaded in balb / c mice. after vaccination with the cea gene - modified dc, the survival time of the mice vaccinated with ct26 + ( cea + ) ws prolonged more potently than that of the mice vaccinatd with other dcs
癌胚抗原（ carcinoebryonicantigen ， cea ）是一種研廠鄭州大學2002年碩士畢業論文轉染人癌胚抗原真核表達質粒的人樹突狀細胞的抗瘤作用究最為深入的腫瘤相關抗原（ tumorassociatiednigen ， taa ） ，在90的胃腸道腫瘤、 50的乳腺癌及70的非小細胞肺癌中有高水平的表達，是目前國際上公認的腫瘤標志物。These findings of the specific ctls epitopes in irbp and pedf may lead to improved understanding of the pathogenesis of uveitis. our study also provides a strategy to identify specific ctls epitopes within tumour antigen, which is helpful to make tumour vaccine for the patients
本研究也為尋找腫瘤抗原中具有誘導特異性ctls能力的肽片段提供了一種策略，為制備肽片段腫瘤疫苗提供了理論基礎。The characteristics of this method are : a, directly counting cell number without the influence of the metabolic state of the cells ; b, discrimination of target cells from effector cells in cell - mediated cytotoxicity assay ; c, less treatment step, and free - radioactivity ; d, high sensitivity and reliability. 2, using the above assay, immunofluorescent labeled technique, and flow cytometry, the pbmc proliferation, apoptosis, necrosis, cell cycle, activation, cytokines and membrane marker were detected. the results showed that the number of pbmc reduced, but the activity of pbmc increased dose - dependently ; the reduction of cell number resulted from necrosis and apoptosis ; the supernatant of k562 cell lines were not able to block the cell cycle, but to promote it ; the ratio of t cell subset and the expression of thl and th2 cytokines increased
結合以上創建的方法和免疫熒光流式細胞術，用k562細胞株可溶性分泌物（上清）對外周血單個核細胞（ pbmc ）進行培養以模擬體內微環境，然後分別從細胞增殖、凋亡、壞死、細胞周期、活性、細胞因子和表面抗原表達等方面進行研究，結果發現用腫瘤上清培養的pbmc細胞數量下降明顯，但同時對其有激活作用，且呈劑量依賴性；細胞數的下降主要是由細胞壞死和凋亡引起的，腫瘤上清對細胞周期沒有阻斷作用，反而略有促進作用； t細胞亞群比例增加，並促進表達th1 、 th2細胞因子。Cells of the immune system taking part in tumor - host interaction include t cells, natural killer cells ( nk cells ) and antigen - presenting cells ( apc, such as dendritic cells, b cells, macrophages )
參與腫瘤免疫的免疫細胞主要有t細胞， nk細胞和抗原提呈細胞（ apc ） 。Dendritic cells ( dc ) is the most powerful apc, which can markedly increase the antigen - presentation capacity by maximizing the pepitide - mhc complexes on the cell surface and upregulating the co - stimulatory ligands b7 - 1 and b7 - 2, adhesion moleculees such as il - 12 that promote full activation of lymphocytes. full activation of antigen - specific t cells requires two signals - one signal coming via the tcr and the other signal through engagment of co - stimulatary molecules. t cells receiving one signal via their tcr are turned off by mhc ( major histocompatibility complex ), via t cell cd28 binding to b7 on the dc induce tlymphokine and t cell proliferatiion
T細胞介導的細胞免疫在控制腫瘤生長方面發揮著重要作用， t細胞在發揮抗瘤效應（分泌細胞因子和直接殺傷）之前必須先經過活化，體內專職抗原提呈細胞（ apc ）細胞並使其活化，樹突狀細胞（ dendriticcell ， dc ）為t細胞的激活提供雙重信號， t細胞藉助tcr識別由dcmhc分子遞交的抗原肽后，通過tcr - cd3復合體傳遞抗原特異性識別信號（第一信號） ，以cd28為主的t細胞表面輔佐分子識別dc表面b7分子，傳遞非特異性協同刺激信號（第二信號） ，在機體抗腫瘤免疫應答中處于核心地位。Focus on research work and clinical studies in musculoskeletal oncology, especially about mechanism and biological therapy of osteosarcoma, such as proteomics studies of osteosarcoma, prospective control study of osteosarcoma, registration system of musculoskeletal oncology and genic tests about the familial inheritance osteoenchondroma, etc
擬開展《骨肉瘤特異性相關抗原的蛋白質組學研究》 、 《骨肉瘤多中心前瞻性隨機對照研究》 、 《骨與軟組織腫瘤注冊-會診-隨訪登記系統》 、 《多發性骨軟骨瘤家族遺傳性基因的檢測》等課題的相關研究工作，承擔國家、省級和市級重大項目等課題的申報。At present, in an attempt to stimulate specific antitumor immunity, experimental models and clinical studies are currently evaluating the potent antigen - presenting capacity of dc combined with single or multiple tumor antigen epitopes. however, there are several problems in utilizing pulsing dc with synthetic immunodominant peptides from identified antigens. 1 ) the potential induction of tolerance ; 2 ) the need to determine the patient ' s hla haplotype, the limitation of therapy to patients whose tumors express defined specific tumor antigens in the context of the correct hla phenotype, the unavailability of peptides for all hla haplotypes ; 3 ) the lack of cd4 help cell - related epitopes for most antigens ; and 4 ) the ctl resulting from such protocols have a good in vitro capacity to kill peptide - pulsed target cells but only a modest capacity to kill tumor cells
但是，學者們發現這一療法存在著如下的缺陷：單一ctl表位抗原肽的應用其抗腫瘤作用弱於多種腫瘤抗原的聯合應用，且有誘導免疫耐受的潛在危險，有時反而會促進腫瘤的生長；事先需對患者的hla單倍型進行鑒定，以確定ctl表位與hla單倍型是否匹配，目前尚缺乏能與所有hla單倍型相匹配的ctl表位，從而限制了這一療法的應用；這一療法所產生的ctl在體外能有效殺傷經腫瘤抗原肽共孵育過的靶細胞，但對腫瘤細胞的殺傷能力較弱：這種l表位抗原肽缺乏cd4汀h細胞相關的表位，因此，不能誘導有效的th細胞免疫應答。Dcs play a pivotal role in the development of antitumor immunity. t lymphocytes immune response induced by direct antigen - pulsed dcs can not maintain longer for peptides - mhc department or mhc molecules degeneration. the method of dcs loading with tumor antigen gene is another potential approach to enhancing and maintaining immune response
在用抗原直接刺激dc時，由於抗原- mhc復合物解離或細胞mhc分子降解而不能維持所誘導的t細胞免疫應答，藉助載體把腫瘤抗原基因導入dc后腫瘤抗原在dc內的持續表達能增強其抗原提呈能力並能維持所誘導的免疫效應。Objective from 1990s, the successful cloning of many tumor antigen genes of human kind has driven the development of tumor immunology enormously. and so does it to the application of tumor immunodiagno sties and immunotherapy
目的： 20世紀90年代以來，多種人類腫瘤抗原基因克隆的成功，大大推動了腫瘤免疫學理論的發展，也促進了腫瘤免疫診斷和免疫治療的應用。Tumor antigens of hepatocellular carcinoma and its specific cellular immunity
肝癌的腫瘤抗原與特異性細胞免疫Tumor cell - derived exosomes containing tumor antigens and mhc class i molecule could present tumor antigens to dcs and induce cd8 + t cell - dependent antitumor immune responses significantly
其含有mhc類分子和lamp - 1 ，能夠將腫瘤抗原呈遞給抗原遞呈細胞，產生顯著的cd8 ~ + t細胞依賴的抗腫瘤免疫反應。It has been reported by candido et al ( 2001 ) that intratumoral delivery of dc could efficiently induce specific antitumor immunity, resulting in tumor growth inhibition in established breast cancer
若能通過直接瘤內注射的方法，讓dc在腫瘤局部獲得相應的腫瘤抗原以誘導機體產生抗腫瘤免疫，無疑是最經濟、最簡便、具有臨床應用前景的方法。Though with various advantages, these tumor vaccines are because of complicated to prepare, restricted availability of relevant tumor antigens, the lack of molecularly defined tumor antigen delivery or targeting systems and the effects are relatively not promising
這些腫瘤疫苗的制備機理均在於提高對腫瘤抗原的遞呈作用。缺點是制備工藝復雜、效果相對不夠理想。 exosomes是由多種細胞分泌的來源於多囊泡體的小的膜性囊泡。To circumvent these deficits, novel antigen - delivery systems utilizing cytokine gene - modified tumor cells and dc or fusion of dc with tumor cells have resulted in induction of antitumor immunity. however, this u approach is difficult in some cases ( for example in breast cancer ) because only rarely has it been possible to isolate enough viable tumor cells from an individual to prepare the vaccine
為了克服上述缺陷，有學者採用滅活的腫瘤細胞、腫瘤抗原提取物（包括腫瘤細胞裂解物、 it na和洗脫肽等）沖擊致敏dc或將腫瘤細胞與dc融合后再回輸體內以激發機體的抗腫瘤免疫應答，也取得了較好的療效。Methods employed to prepare vaccine include rumor cells genetically modified with cytokines, costimulatory molecules and tumor antigenic peptides, dendritic cells ( dc ) primed with tumor antigens in vitro or genetically modified with tumor antigens, or fusion of tumor cells with antigen presenting cells ( apc )
現有的比較受到關注的制備腫瘤疫苗的方法有各種細胞因子、共刺激分子、腫瘤抗原肽等基因修飾的腫瘤細胞疫苗；體外抗原致敏的或腫瘤抗原肽基因修飾的樹突狀細胞疫苗；腫瘤細胞與抗原遞呈細胞融合疫苗等。分享友人