誘癌劑 的英文怎麼說
中文拼音 [yòuáijì]
誘癌劑
英文
carcinogen-
The widespread use of x - ray in medical diagnosis and treatment for some diseases in the early 30 s without realizing its harmful effects led to cases of radiation dermatitis and chronic ulceration, eventually resulting in radiation induced cancers. following these, various radiation induced malignances surfaced one after another, drawing attention on the detrimental effects due to radiation
在30年代初期， x射線和放射性核素曾應用於治療某些疾病。由於病人累積過高劑量，曾誘發白血病和肝癌、骨癌等惡性腫瘤。其後種種因輻射而誘發的疾病相繼發現，引起了人們對輻射危害的關注。Monofunctional alkylating agent n - methyl - n ' - nitro - n - nitrosoguanidine ( mnng ) is a widely spread environmental mutagen and carcinogen that targets dna and proteins to generate adducts. among the adducts, o6 - alkyl guanine is the predominant mutagenic lesion because of its mispairing properties, which can eventually lead to chromosomal aberrations, point mutations, and cell death. this lesion also appears to be involved in tumor initiation, particularly in gastric carcinogenesis
單功能烷化劑n -甲基- n -硝基- n -亞硝基胍（ mnng ）是一種在環境中廣泛存在的化學誘變劑和致癌劑，它能和dna及蛋白質等生物大分子形成加合物（ adduct ） ，其引起的與突變有關的主要dna損傷類型是o ~ 6 -甲基鳥嘌呤，這種損傷與腫瘤尤其是胃癌的發生密切相關。Therefore, it is important to study the profiles of gene expression, which will help understand the global cellular stress responses to chemical carcinogens, and further elucidate the mechanisms of nontargeted mutagenesis
所以，從整體上研究烷化劑作用后細胞基因表達譜改變，對于了解化學致癌物誘發的哺乳動物細胞應激反應的全貌和揭示非定標性突變的發生機制具有非常重要的意義。In our laboratory, a unique mutation detection system using a shuttle vector plasmid has been established to demonstrate that a low concentration of mnng ( 0. 2 m ) can induce nontargeted mutation in mammalian cells : the mammalian cells were exposed to 0. 2m mnng for 2. 5h, then a shuttle plasmid pz189 carrying supf trna gene was transfected into cells after 24h culture. we found a 5 - fold higher mutation frequency of the plasmid replicated in pretreated cells than the spontaneous mutation frequency of the plasmid replicated in control cells. this kind of mutation did not occur immediately after mnng exposure
我們實驗室曾用一特殊的突變檢測系統，直接證明dna損傷劑可在哺乳動物細胞誘發非定標性突變：首先用低濃度（ 0 . 2 m ）的短壽烷化劑mnng （半壽期為1 . 1hr ）處理細胞2 . 5h后，繼續培養24h ，將重組有用作突變檢測的靶基因supftrna基因的穿梭質粒pz189轉入細胞復制，發現在未受致癌物直接攻擊的穿梭質粒中有較自發突變率高5倍以上的靶基因突變。The purpose of this study is to compare the keratin profile in dmba - induced squamous cell carcinoma with that in normal hamster cheek pouch epithelium
摘要本篇是誘癌劑dmba所引發倉鼠頰囊袋之鱗狀上皮樣癌與正常囊代表皮中之角質蛋白之比較研究。In 1945, government researchers realized that nitrates and nitrites, commonly used to preserve color in meats, and other food additives, caused cancer
1945年，政府部門的科研工作者了解到，被廣泛用於肉類以保持肉類色澤的硝酸鹽、亞硝酸鹽和其他的添加劑可誘發癌癥。In order to further investigate the role of axudl in human tumor carcinogenesis and the potential association between the axudl gene expression status and the stimulation of transforming growth factor beta in human cancers, the present study was performed in three aspects as follows : ( 1 ) cloning full length enconding region cdna of axudl and construction of eukaryotic vector that expression the fusion protein of axud1 and influenza virus hemagglutin ha epitope tag ; ( 2 ) exploring the time and dose effects of tgf - 1 on the expression - of axudl gene in hepg2 hepatoma cells and spc - a1 lung carcinomas cells, and studying the effects of overexpression of axud1 on the expression of cell cycle and apoptosis related protein in hepg2 hepatoma cells ; ( 3 ) construction and expression of human axudl in e. coli m15. the following main results and conclusions can be obtained from the present study : 1. the full length ecnoding region of human axudl cdna from human peripheral blood lymphocytes was successfully cloned using one step rt - pcr method, and constructed into a eukaryotic expression vector which can be expressed a ha - axud1 fusion protein with axud1 and influenza virus hemagglutin ha epitope tag. the recombinant plasmid was identified by polymerase chain reaction, restriction endonuclease maping and sequencing, this expression vector might be instrumental to further study the function of axud1 protein in tumor cells
為了進一步研究axud1在人類腫瘤發生中的作用及axud1基因的表達狀況與tgf -介導的信號通路的關系，本實驗研究分為三個部分： （ 1 ） axud1基因cdna全長編碼區的克隆和ha表位標記的axud1基因表達載體的構建； （ 2 ）探討肝癌細胞hepg2和肺腺癌spc - a1細胞中tgf - 1誘導的axud1基因表達的時間、劑量效應以及誘導表達的可能機理，並研究axud1的過表達對細胞周期和細胞凋亡相關蛋白表達的影響； （ 3 ） axud1原核表達載體的構建及其在大腸桿菌中的表達。本實驗的主要結果和結論如下： 1利用一步法rt - pcr成功地從人類外周血淋巴細胞中克隆出axud1基因編碼區cdna ，並將其構建入真核表達載體中，編碼的ha - axud1融合蛋白帶有流感病毒凝血素ha的表位標記肽段。In 1994, conry firstly constructed cea dna vaccine, studied its immunological effects and made great achievements. in order to enhance dna vaccine efficacy, researchers are inclined to employ effective and safe vectors, co - delivery cytokines recombinant or adhesion molecules, iss, and so on
1994年， conry鄭州大學醫學院2002研究生畢業論文癌胚抗原a疫苗構建及佐劑對其兔疫效應的影響就構建了ceadna疫苗，並在動物體內誘導產生了良好的兔疫效果。Studies on liver cancer induced by non - necrotizing dose of diethylnitrosamine in rats
非壞死劑量二乙基亞硝胺誘發大鼠肝癌模型的研究分享友人