誘變致癌物 的英文怎麼說
中文拼音 [yòubiànzhìáiwù]
誘變致癌物
英文
mutagenic carcinogen-
Diet acrimony, sootiness, salt bloats, mildew changes, cankered food : hot food stimulates gastric mucous membrane, as time passes injures gastric mucous membrane ; carcinogenic substance of fumigated food generation can be caused and aggravating illness ; nitric acid salt is contained in souse food, very powerful carcinogen can be formed after with food medium nitrite is united in wedlock - - inferior saltpetre amine ; mildew changes element of very strong carcinogen yellow aspergillus is contained in food ; cankered material can produce effluvial carcinogen aldehyde. 2
忌食辛辣、煙熏、鹽腌、霉變、腐爛食品：辛辣食物刺激胃粘膜，久而久之損傷胃粘膜；熏制食物產生致癌物可誘發和加重病情；腌制食物中含有硝酸鹽，和食物中的亞硝酸鹽結合后可以形成很強的致癌物質? ?亞硝胺；霉變食物中含有很強的致癌物質黃麴黴素；腐爛的物質可以產生惡臭的致癌物質乙醛。Phenanthrene is one of three - aromatic pahs and distributes in environments widely, which causes diseases of human respiration system and skin, and induces mutation, aberrance and carcinogen of fish and other animals
菲為一種廣泛分佈於自然環境的三環芳烴，能導致人類呼吸系統和皮膚的病變，可誘發魚類和其它生物的突變、畸變與癌變。Monofunctional alkylating agent n - methyl - n ' - nitro - n - nitrosoguanidine ( mnng ) is a widely spread environmental mutagen and carcinogen that targets dna and proteins to generate adducts. among the adducts, o6 - alkyl guanine is the predominant mutagenic lesion because of its mispairing properties, which can eventually lead to chromosomal aberrations, point mutations, and cell death. this lesion also appears to be involved in tumor initiation, particularly in gastric carcinogenesis
單功能烷化劑n -甲基- n -硝基- n -亞硝基胍（ mnng ）是一種在環境中廣泛存在的化學誘變劑和致癌劑，它能和dna及蛋白質等生物大分子形成加合物（ adduct ） ，其引起的與突變有關的主要dna損傷類型是o ~ 6 -甲基鳥嘌呤，這種損傷與腫瘤尤其是胃癌的發生密切相關。Analysis on hypervariable sites in mitochondrial dna of malignant transformed cells induced by trans - bpde and nickel sulfide
致癌物誘導惡變細胞中線粒體高變區序列分析Therefore, it is important to study the profiles of gene expression, which will help understand the global cellular stress responses to chemical carcinogens, and further elucidate the mechanisms of nontargeted mutagenesis
所以，從整體上研究烷化劑作用后細胞基因表達譜改變，對于了解化學致癌物誘發的哺乳動物細胞應激反應的全貌和揭示非定標性突變的發生機制具有非常重要的意義。In our laboratory, a unique mutation detection system using a shuttle vector plasmid has been established to demonstrate that a low concentration of mnng ( 0. 2 m ) can induce nontargeted mutation in mammalian cells : the mammalian cells were exposed to 0. 2m mnng for 2. 5h, then a shuttle plasmid pz189 carrying supf trna gene was transfected into cells after 24h culture. we found a 5 - fold higher mutation frequency of the plasmid replicated in pretreated cells than the spontaneous mutation frequency of the plasmid replicated in control cells. this kind of mutation did not occur immediately after mnng exposure
我們實驗室曾用一特殊的突變檢測系統，直接證明dna損傷劑可在哺乳動物細胞誘發非定標性突變：首先用低濃度（ 0 . 2 m ）的短壽烷化劑mnng （半壽期為1 . 1hr ）處理細胞2 . 5h后，繼續培養24h ，將重組有用作突變檢測的靶基因supftrna基因的穿梭質粒pz189轉入細胞復制，發現在未受致癌物直接攻擊的穿梭質粒中有較自發突變率高5倍以上的靶基因突變。分享友人