轉錄激活因子 的英文怎麼說

中文拼音 [zhuǎnlùjīhuóyīnzi]
轉錄激活因子 英文
activating transcription factor
  • 轉 : 轉構詞成分。
  • 錄 : Ⅰ名1 （用做記載物的名稱） record; register; collection; selections 2 （姓氏） a surname Ⅱ動詞1 （...
  • 激 : Ⅰ動詞1 （水因受到阻礙或震蕩而向上涌） swash; surge; dash 2 （冷水突然刺激身體使得病） fall ill fr...
  • 活 : Ⅰ動詞1 （生存; 有生命） live 2 [書面語]（救活） save （the life of a person）:活人無算 （of a goo...
  • 因 : Ⅰ動詞[書面語] （沿襲） follow; carry on Ⅱ介詞1 [書面語] （憑借; 根據） on the basis of; in accord...
  • 子 : 子Ⅰ名詞1 （兒子） son 2 （人的通稱） person 3 （古代特指有學問的男人） ancient title of respect f...
  • 轉錄 : [電學] transcribe; transfer; [聲學] mixing; rerecording; [生物學] transcription; duplicating轉錄...
  • 激活 : activation; sensitization; activate; sensitize; active激活材料 active material; 激活劑 activating...
  1. Comprehensive cellular responses was found in human amnion fl cells following exposure to low concentration of mnng, such as the lowering of dna replication fidelity resulted from alteration of dna polymerase profile ; activation of a lot of transcription factors, such as api, creb, nf - kb etc ; clustering of egfr ( epidermal growth factor receptor ) and tnfr ( tumor necrosis factor receptor ) and activation of camp - pka - creb and jnk / sapk signal pathways

    我們發現，低劑量mnng處理后的人羊膜fl細胞有廣泛的細胞反應，並有多個信號轉導通路的激活和基因表達的改變。例如dna復制保真度下降， dna聚合酶譜發生改變，應用報告基因技術和底物磷酸化檢出技術證明細胞一系列轉錄因子如ap1 、 creb 、 nf b等被激活，細胞表面受體如表皮生長因子受體、腫瘤壞死因子受體發生聚簇，細胞信號轉導通路camp - pka - creb和jnk sapk被激活。
  2. Notch interaction with its ligands induces the cleavage of its intracellular domain ( ic ), and the notch ic translocates to the nucleus and binds to rbp - j, the mammalian homolog of su ( h ), to transactivate transcription of target genes such as e ( spl ) ( enhancer of split ), hesl ( hairy and enhancer of split ) and hes5 four notch receptors and their ligands are differentially and redundantly expressed in a variety of vertebrate tissues

    它通過其識別序列（ cogtgggaa ）結合於受調控基因的啟動子區，在轉錄激活因子的驅動下調節細胞分化和個體發育相關基因的表達。在沒有n 。 tch胞內段的情況下， rbpj可與包含sm盯（ silencingmediatorforretlnoldandthyroidhormonereceptor ）和組蛋白去乙酞化酶的轉錄輔助抑制復合物結合，當notch信號被激活時； rbpj可與n 。
  3. The two single - pass transmembrane proteins, delta and serrate, have been identified as notch ligands. the transcription factor suppressor of hairless [ su ( h ) ] is the major downstream effector of notch signaling pathway. rbp - j, the mammalian homolog of su ( h ), recognizes the core sequence ( c / tgtgggaa ) of dna

    Rbp - j是果蠅促神經發生基因su （ h ） （ suppressorofhairless ）在哺乳動物的同源物，它通過其識別序列（ c tgtgggaa ）結合於受調控基因的啟動子區，在轉錄激活因子的驅動下調節細胞分化和個體發育相關基因的表達。
  4. Zygotic genome activation ( zga ) is a nuclear reprogramming event that transforms the genome from transcriptional quiescence at fertilization to robust transcriptional activity shortly thereafter

    合子基因組激活（ zga ）是一個細胞核重編程事件，使基因組從受精時的轉錄靜止轉變為立即的活躍轉錄。
  5. Stat3 ( signal transducer and activator of transcription 3 ) is important for embryo morphogenesis, cell growth, apoptosis and cell mobility

    信號轉導和轉錄激活因子3 （ stat3 ）在動物的早期胚胎發生、細胞生長、凋亡控制和細胞運動等過程中起著很重要的作用。
  6. Abstract : plant responses to salt stress via a complex mechanism, including sensing and transducing the stress signal, activating the transcription factors and the corresponding metabolizing genes. since the whole mechanism is still unclear, this review emphasize the biochemical events during the plant adaptation to salt stress referring to an index of importance : the homeostasis in cytoplasm, the biosynthesis of osmolytes and the transport of water. most of these biochemical events were elucidated by study of halophyte and salt - sensitive mutations, also many important genes involved were cloned and used to generate stress - tolerance phenotypes in transgenic plants. on the other hand, about the molecular mechanism in signal transduction, the research of arabidopsis mutations and yeast functional complementation provided helpful traces but not full pathway

    摘要植物對鹽脅迫的耐受反應是個復雜的過程，在分子水平上它包括對外界鹽信號的感應和傳遞，特異轉錄因子的激活和下游控制生理生化應答的效應基因的表達.在生化應答中，本文著重討論負責維持和重建離子平衡的膜轉運蛋白、滲調劑的生物合成和功能及水分控制.這些生理生化應答最終使得液泡中離子濃度升高和滲調劑在胞質中積累.近年來，通過對各種鹽生植物或鹽敏感突變株的研究，闡明了許多鹽應答的離子轉運途徑、水通道和物種特異的滲調劑代謝途徑，克隆了其相關基因並能在轉基因淡水植物中產生耐鹽表型;另一方面，在擬南芥突變體及利用酵母鹽敏感突變株功能互補篩選得到一些編碼信號傳遞蛋白的基因，這些都有助於闡明植物鹽脅迫應答的分子機制。
  7. Ie protein have multiple functions, such as conversion of the host cell into a metabolically activate states, activation of viral early genes in the early phase, repression of their own transcription. ie 180 proteins can stimulate transcription from both homologous such as the icp4 of hsv ( herpes simplex virus ) and heterologous viral and cellular promoter such as - globe protein

    經分析偽狂犬病病毒立即早期蛋白（ immediate - earlyprotein180 ， ie180 ）的蛋白質結構，發現ie180具有轉錄激活因子的結構特徵，能與類rna聚合酶結合， ie180基因缺失突變體對sv40及cmv啟動子調控作用的研究，是考察ie180能否作為轉錄激活因子應用的關鍵。
  8. To further enhance protein productivity of expression vectors, two artificial transcription activating domains, ah and vp2, were linked to cl represser protein of phage through a soft linker, respectively, and thus two artificial transcription activators were created

    為了進一步提高表達載體表達外源蛋白的能力，我們把兩個人工轉錄激活結構域ah和vp2分別通過一個柔性的linker融合到噬菌體ci蛋白的c末端，構建了兩個人工轉錄激活因子。
  9. All the components mentioned above were integrated into ped5, producing two vectors : per - ah and per - vp2. the two vectors were tested for their efficiency of expressing ifn - and seap reporter genes in comparison with perfrt, a vector similar to per - ah and per - vp2 except for lacking of artificial transcription activators

    以ifn -和seap報告基因對其表達效果進行檢測，結果per - ah表達外源蛋白的能力僅略高於perfrt （一個除了不含人工轉錄激活因子外，其餘都與per - ah或per - vp2完全相同的載體） 。
  10. There is no characteristic in the amino acid sequence 63 - 152 and it is the piece that we want to delete to identify the function of the segment. ie180 gene mutants deleted the 64 - 151 amino acid was amplified by muti - pcr and were cloned by pmdist - vector. the clone plasmids were named pjmp1p3p2. the segment corresponding to the sequence of 1 - 1079 amino acid of the genbank sequence amplified by pcr, its clone plasmids was named pjmp1p2. the segment corresponding to the sequence of 454 - 1079 of genbank sequence amplified by pcr and its clone plasmids is named pjmp6p2 - three clone plasmids and pcdna3 were digested by restriction enzyme bamhi and hind, the gene segment of p1p2, p1p3p2, p6p2 were recycled

    本試驗應用dnamis及prosis軟體分別對genbank中登記號為no352564的ie180序列進行了蛋白質序列分析，結果表明其1 - 34段氨基酸序列具有典型helix - turn - helix特徵序列，並且富含酸性氨基酸d及e ，是典型的dna識別序列；富含絲氨酸序列的152 - 409氨基酸序列是一個與激活有關的、潛在的磷酸化位點； 454 - 696氨基酸區域是dna結合域； 64 - 151氨基酸片段沒有明顯的序列特徵；從中可看出ie180蛋白的1 - 1080氨基酸段具有典型的轉錄激活因子結構特徵。
  11. One is as signal transducers outside of the nucleus, named nongenomic action. the other is as transcription activators in the nucleus, named genomic action. the two ways may coexist, cooperate and coregulate in the development and maturation of oocyte

    類固醇激素受體在卵母細胞中可能通過兩種途徑發揮作用，一種是存在於胞質中，作為信號轉導因子的非基因組調控機制；另一種是存在於核中，作為核轉錄活性因於，改變基因轉錄活動的基因組調控機制。
  12. Nf - k. b can be activated by lps and regulate transcription of many pro - inflammatory cytokines

    Lps可激活m4b ，調節許多炎性細胞因子的轉錄。
  13. Hypoxia - inducible factor ( hif ) is an oxygen - dependent transcription factor that activates a diverse set of target genes, the products of which are involved in adaptive processes to hypoxia

    低氧誘導因子（ hif ）是一種氧依賴性的轉錄因子，其為低氧適應性過程中的產物，可激活各種靶基因。
  14. Further, in the mouse spleen t lymphocytes activation system, it was found that, without activation by cona, there were no or extremely low level of expression of baf complex and nf1 / ctf in the spleen t lymphocytes

    進一步用小鼠t淋巴細胞活化體系的研究發現，未經cona激活的t淋巴細胞中， baf復合物和轉錄因子nf1 ctf不表達或低水平表達。
  15. In order to get some functional clues from their structures, the upstream regulation region of ndrgl gene and second structure of ndrg2 protein are performed bioinformatics analysis ; we found that there are several binding sequences of some diffirent transcription factors, their functions include regulating tissue - specific gene expression, regulating expression of genes related to growth and early development of cells, besides this, regulating expression of genes under some stimulated conditions, and so on. predict in protein fold classification shows that ndrg2 belongs to alpha / beta hydrolase fold family, and there are high similarity between ndrg2 and epoxide hydrolase from bacteria, this suggests that ndrg2 protein may has enzymatic functions associated with resisting the oxidative stress, maintaining the balance of cell redox potential, involving in the metabolism process of xenobiotics or intracellular toxic molecules

    研究發現呷基因的調控區存在多種轉錄因子結合位點，功能主要涉及組織特異性表達調控，細胞生長發育相關基因的表達調控，刺激反應基因的表達調控等； ndrgz蛋白在結構上屬于a小水解酶類折疊，折疊分類預測表明ndrg2與其中的的細菌環氧化物水解酶的二級結構極為相似，提示ndrgz蛋白具有一定酶活性，可能參與細胞抗氧化應激反應，維持細， an ） armtbffiofbfochmilsyn ） mdafblechmrbfobo4第四軍醫大學碩士學位論文胞內氧還電勢平衡，參與內外源有毒物質的代謝等。
  16. After activated by cona, the mouse spleen t lymphocytes started expressing baf complex and nf1 / ctf. the longer the stimulation, the higher the expression level of baf complex and nf1 / ctf in the cells

    經cona激活后，小鼠脾t淋巴細胞中baf復合物和轉錄因子nf1 ctf開始表達，隨著刺激時間的增加，表達量增加。
  17. Somewhere along the road to malignancy, the same mutant transcription factor that had switched on the genes enabling the tumor cells to divide unchecked had apparently also switched on the genes needed to produce leu - enkephalin

    在發展成為惡性腫瘤的過程中，同樣的突變轉錄因子不僅激活了能夠使癌細胞無限分裂下去的基因，而且同時激活了能產生亮氨酸腦啡肽的基因。
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