阻抑啟動子 的英文怎麼說
中文拼音 [zǔyìqǐdòngzi]
阻抑啟動子
英文
repressible promoter-
2. specific mutation from a to c at - 137 bp site upstream from transcription start point had no effect on the inducibility of the promoter in response to sa and bth. 3
在轉錄起始點上游137bp定點將a突變為c后,對化學啟動子的化學誘導應答性沒有明顯的影響,但對誘導效應的向上運輸存在一定程度的阻抑作用。Kyot2 lacked two lim domains from the c terminus and had a frameshift in the last exon, creating the rbp - j - binding region in the c terminus. kyotl had a negligible level of interaction with rbp - j. the binding site of kyot2 on rbp - j overlaps those of ramic and kyot2 repressed the rbp - j mediated transcriptional activation by ramic by competing with them for binding to rbp - j
在肌肉母細胞系czc12內過表達kyoth時可阻斷轉錄激活物notch胞內區或ebnaz對rbp依賴性啟動子的轉錄激活作用,這種阻斷作用呈劑量依賴性,提示kyoth可與notch胞內區或ebnaz競爭rbp j上的結合位點,從而抑制二者的轉錄激活活性
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