靶酶 的英文怎麼說

中文拼音 [bǎ]
靶酶 英文
target enzyme
  • 靶 : 1. （射擊的目標） target 2. （轡革; 韁繩） bridle; halter; reins
  • 酶 : 名詞[生物化學] （生物體的細胞產生的有機膠狀物質） enzyme; ferment
  1. Recently, the chinese plant protection agencies reported the growing hardships in controlling some field populations of oriental migratory locust with organophosphate ( op ) compounds. up to now there are more than 600 arthropod species with documented resistance to one or more insecticides and / or acaricides since resistance phenomenon was first described in san jose scale to lime - sulfur in washington in 1908. enhanced metabolic detoxification and reduced sensitivity of insecticide target - sites are the two major mechanisms in resistance development, involving three primary metabolic enzymes of esterases, glutathione s - transferases and cytochrome p450 polysubstrate monooxygenases

    代謝抗性是指對殺蟲劑起水解或隔離作用的酶發生改變，從而對殺蟲劑起到解毒作用，昆蟲主要解毒酶系有酯酶、谷胱甘肽- s -轉移酶、細胞色素p450單加氧酶等，這三種酶系任何一種的組成部分發生改變均會引起害蟲抗性的改變；靶標抗性是指由於殺蟲劑作用靶標敏感度降低而產生的抗性。
  2. Constructing human colorectal cancer cell line with stably down - regulated grp94 ( 1 ) the plasmid prc / rsv - ribol that contains specific grp94 - targeting ribozyme and the control plasmid prc / rsv were miniprepared, respectively, cleaved by endoenzyme pvuii

    穩定下調grp94的人大腸癌細胞克隆株的構建（ 1 ）分別對含有特異性打靶grp94核酶的質粒prc rsv - ribo1和對照組質粒prc rsv進行小量提取、 pvu酶切鑒定。
  3. Advance in antitumor agents targeting glutathione s transferase

    轉移酶為靶點的抗腫瘤藥物研究進展
  4. Estrogen ( e2 ) is one of the steroid hormones, which is mainly synthesized and secreted by the gonad affecting proliferation, differentiation and function exerting of target tissues. circumferential estrogens were mainly produced by ovary and spermary, and the brain estrogens came mostly from hypothalamus, neurons of limbic system and neuroglias

    雌激素四）是由芳香化酶催化雄激素轉化而來的，它影響靶組織的生長分化和功能發揮，外周雌激素主要由卵巢、睪丸產生，腦內主要由下丘腦、邊緣系統的神經元和神經膠質細胞產生。
  5. 4. engineering dhqase ( arod ) - deficient e. coli mutant with a second copy of the arob gene gene targeting technique was used to disrupt the arod gene in e. coli chromosome. the mutant 31bk was engineered, in which homologous recombination of the arobkanr gene cassette into the arod locus ( arod : : arobkanr ) of the e. coli strain atcc31884 genome utilized the helper plasmid pkd46 with red system. the host cell 31bk lacked catalytic activity of dhqase ( arod ) and had a second copy of the arob gene, so it improved carbon flow into the quinic acid biosynthesis direction

    構建宿主菌基因精確定位突變株31bk （ arod : : arobkan ~ r ）為了改變代謝途徑脫氫奎尼酸（ dhq ）分支點上的代謝流量，使之充分流向目的產物奎尼酸合成方向，利用基因打靶技術構建了31884宿主菌arod基因精確定位插入突變體，使dhq脫水酶（ dhqase ）失活，阻斷了碳代謝流流向芳香氨基酸生成的方向，同時用同源重組的方法將arob基因定位整合入染色體上，解除了限速酶對碳代謝流通過共同途徑到達dhq的阻遏影響，並減輕代謝負擔。
  6. Based on this consideration, we chose human colorectal cancer cell line ccl229 as the experimental object, down - regulating its grp94 expression by specific ribozyme targeting. we observed its effects on the biological characteristics of ccl229 and upr pathway, and gained further understand of the grp94, upr and tumor relationship

    基於此，我們選擇了人大腸癌細胞株ccl229作為研究對象，通過特異性核酶打靶的方式，下調細胞中grp94的表達水平，觀察其對人大腸癌細胞某些生物學特性及upr通路的影響，加深對grp94 、 upr和腫瘤這三者間關系的了解。
  7. Found the phenomenon observed in the nematode caenorhabditis elegans for the first time in 1998, consequently similar processes have been described for drosophila melanogaster, trypanosome, mammals including humans. the mechanism is that sirnas is the mediator, which can induce the risc to the target mrna and degrade it. recently there was great progress in the specific gene therapy and anti - virus, and rnai has been a focus of rna molecular therapy

    自1998年fire等在研究線蟲時首次發現以來，相繼在果蠅、渦蟲、錐蟲、小鼠及哺乳動物細胞中發現rnai現象。一般認為： rnai第四軍醫大學碩士學位論文效應作用機制是sirnaskmallinterferinguaduplex ）作為中介分于，引導risc （ rnaiinducingsuppresscomplex ）至靶基因m洲a處，隨后核酸內切酶將之降解。
  8. The cowpea trypsin inhibitor ( cptt ) gene is testified as a broad spectrum insect - resistant gene at present and its application in insect - resistant botanic transgenic engineering only after s / gene. the cpti transgenic plant developed rapidly for it ' s broad spectrum insect - resistant character and the target insects are uneasy tolerance to it

    豇豆胰蛋白酶抑制劑（ cpti ）基因是目前在植物抗蟲基因工程中應用僅次於bt基因的廣譜性抗蟲基因。鑒於它抗害蟲的廣譜性和靶標昆蟲不易對其產生耐受性的優點，轉cpti基因植物得到了迅速的發展。
  9. The cyst cells enclosing spermatomeres maybe synthesize a kind of scf - like protein, which can recognize specially the c - kit receptor on the cellular membrane of spermatomeres. then c - kit is activated, dimerizing and autophosphorylating. at the same time, the tyrosine kinase domain of c - kit is activized, which phosphorylates the proteins that have sh2 domain

    精母細胞周圍的囊細胞可能合成scf樣蛋白，特異地識別精母細胞膜上的c - kit受體，並刺激c - kit發生二聚化、自體磷酸化，激活胞內酪氨酸激酶活性，活化具有「 sh _ 2結構域」的靶蛋白，可能通過一系列信號級聯，最終激活與減數分裂的相關蛋白或基因。
  10. No, a first gas information molecule discovered in human being, is a typical endothelial - derived relaxant and mediates endothelium - dependent relaxation of blood vessels. in the pathogesis of endotoxin shock vec is one of the major target cells of lps and lps - induced proinflammatory cytokine such as tumor necrosis factor and interlukin 1 and activated. in vec inducible nitric oxide synthase ( inos ) is induced and lead to an increase in production of no, the while endothelial nitric oxide synthase ( enos ) is inhibited and elicit decrease in no formation, both of which are demonstrated to induce the

    在內毒素休克過程中vec是lps及其誘導機體產生的多種促炎細胞因子如tnf 、 il - 1作用的主要靶細胞， vec誘導型一氧化氮合酶（ induciblenitricoxidesynthase ， inos ）激活、 no大量誘生而內皮型一氧化氮合酶（ endothelialnitricoxidesynthase ， enos ）活性被抑制、 no生成障礙，是血管反應性異常變化、血管調節機制紊亂的重要發病環節。
  11. Epsp synthase is a attractive prime target for many antimicrobial agents and herbicides

    該酶是許多抗生素、除草劑作用的首選靶標酶。
  12. There are two kinds of receptor proteins of bt toxic protein in insect body, aminopeptidase receptors and cadherin - like receptors

    靶標昆蟲中bt受體蛋白主要有兩類：氨肽酶和類鈣粘蛋白。
  13. They discovered that existing anti - fungal treatments based on azoles already target p450s, for instance in the treatment for candida albicans ( the causative agent of thrush )

    他們還發現現有的存在於抗真菌治療藥物中的氮雜茂已經具有針對p450酶類的靶點，比如用於白色念珠菌（鵝口瘡的病原體）治療時。
  14. This paper reviewed the progress of targeted therapy of cancer from points of view of western and chinese traditional medicine and clarified the multiple target effect of chinese materis medica of ant - angiogenesis of cancer, inducing apoptosis and inhibition of telomerase activity

    摘要從中西醫角度分別綜述腫瘤靶向治療的研究進展，闡述中藥在腫瘤治療中的抗腫瘤血管生成、誘導細胞凋亡和抑制端粒酶活性的多靶點效應。
  15. Gefitinib ( iressa, zd1839 ), a specific tyrosine kinase inhibitor that targets the epidermal growth factor receptor ( egfr ), is a novel molecular - targeting antineoplastic agent

    摘要吉非替尼是一種新型的分子靶向抗癌藥物，它選擇性抑製表皮生長因子受體酪氨酸激酶而發揮作用。
  16. Sorafenib, a novel, oral multi - kinase inhibitor, targets on serine / threonine and receptor tyrosine kinases of the tumor cells and vasculature ; blocks the signal transconduction and inhibits tumor growth

    摘要索拉非尼是首個口服多激酶抑制藥，靶向作用於腫瘤細胞和腫瘤血管上的絲氨酸和（或）蘇氨酸及受體酪氨酸激酶，阻斷信號傳導，抑制腫瘤生長。
  17. Several kinds of preparation methods and the applied developments of magnetic polymer microsphere in cell separation, immobilized enzyme, dna separation and medicine carrier are discussed in detail, and the prospects of magnetic polymer microsphere are also proposed

    在此基礎上，對磁性高分子微球在細胞分離、固定化酶、靶向藥物、核酸分離等領域的最新應用及存在的問題進行了分析，並指出了該領域今後的研究方向。
  18. Telomerase is a new target of oncotherapy, the growth of tumor could be repressed by restraining telomerase activation

    端粒酶已成為新的腫瘤標志物及腫瘤治療的新靶點，抑制腫瘤細胞端粒酶活性可望達到抑制腫瘤生長的目的。
  19. Resistance would be developed when the activities of any of these three enzymes are increased. the three insecticide target - sites are acetylcholinesterase ( ache ) for organophosphate and carbamate insecticides, voltage - gated sodium channels : knockdown resistance ( kdr or kdr - type ) for ddt & pyrethroids and y - aminobutyric acid ( gaba ) receptors for cyclodienes

    殺蟲劑的作用靶標主要有：有機磷和氨基甲酸酯殺蟲劑的作用靶標?乙酰膽堿酯酶； ddt和擬除蟲菊酯類殺蟲劑的作用靶標?神經軸突鈉離子通道；環戊二烯類和吡唑類等殺蟲劑的作用靶標? -氨基丁酸（ gaba ）受體-氯離子通道復合體。
  20. It presented a natural target because aromatase converts testosterone into estradiol, a potent form of estrogen also used in hormone replacement therapy

    由於芳香酶能把睪酮轉化為雌二醇，而雌二醇也是一種能用於激素替代療法的雌激素，它就提供了一個天然的靶點。
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