blys 中文意思是什麼
blys
解釋
激活因子-
The b lymphocyte stim lator ( blys ) also known as baff, tall - 1, thank, ztnf4, is the most recent addition to the tumor necrosis factor family ( tnf ) ligands. blys induces both in vivo and in vitro b cell proliferation, differentiation and immunoglob lin secretion. meanwhile, it also strongly suppresses the growth of tumor cell lines. the over - production of blys is associated with the development of certain autoimmune disease, such as systemic lupus erythaematosus ( sle ), rheumatoid arthritis, myasthenia gravis, sj greh ' s syndrome
人b淋巴細胞刺激因子（ hblys ）是1999年發現的腫瘤壞死因子超家族成員。最早發現其可誘導腫瘤細胞凋亡，之後發現它是一個強有力的b細胞共刺激因子，它在體外及轉基因動物體內可明顯刺激b細胞的生長，免疫球蛋白分泌，並導致動物自身免疫性改變。 -
Therefore, blys, its receptor or related antagonists may find medical utility in the treatment of b cell disorders associated with autoimmunity, neoplasia, or immunodeficiency syndromes. in this study, epo signal peptide sequence and hsblys gene were linked by soe method. the fusion product was cloned into eukaryotic plasmids. pcdna3, pcdna3. 1, pefneo, respectively. meanwhile, the epo signal peptide sequence was mutated so as to form a restriction enzyme cut site : bin i. thus the recombinant plasmid can be used as secreting plasmid expressing other gene
本實驗通過3 』端互補，進行引物延伸合成epo信號肽序列：信號肽和hsblys基因採用重疊延伸拼接法形成融合基因；融合基因分別插入pcdna3 . 0 、 pcdna3 . 1 、 pefneo真核載體：引物延伸合成信號肽時，利用亮氨酸同義密碼，將信號肽基因的倒數第二個密碼突變，在重組載體上的信號肽序列之後，形成bln酶切位點，使三種載體成為分泌表達載體。
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