cerebral localization 中文意思是什麼
cerebral localization
解釋
大腦定位作用- cerebral : adj. 1. 大腦的，腦的。2. （文藝等）觸動理智的；理智方面的；非感情方面的。
- localization : n. 1. 定位，定域。2. 局限。3. 地方化。
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The cellular localization of kvl. 2 and the co - localization of kvl. 2 and vegf receptors in the rat brain in rat cerebral cortex, triple - fluorescence labeling for kvl. 2, nse, and gfap showed that kvl. 2 immunopositive labeling was predominantly seen on the membrane of the cells co - stained with nse, a specific neuronal marker. only few kvl. 2 positive labeling cells were co - stained with gfap, an astrocyte glial cell marker
大鼠腦內kv1 . 2蛋白的細胞定位及其與vegf受體間的共存關系大鼠大腦皮層kv1 . 2 、 nse 、 gfap免疫熒光三標結果： kv1 . 2蛋白分佈在細胞膜上，大部分kv1 . 2免疫陽性細胞表達有nse ，只有在少量kv1 . 2陽性細胞上表達有gfap 。 -
To make clear the hypothesis, a middle cerebral artery occlusion ( mcao ) and hypoxia and glucose - deprivation ( hgd ) ischemic models were used in in vivo and in vitro study, respectively. we first studied the cellular localization of kvl. 2 and the co - localization of kvl. 2 protein and vegf receptors flk - 1 and flt - 1, observed the effect of mcao on kvl. 2 expression and phosphrylation in the rat brain in vivo, then investigated the effect of vegf on ischemia / hypoxia cell damage and tyrosine phosphorylation of kvl. 2 in sh - sy5y cells. finally, in order to further elucidate the relationship between vegf ' s neuroprotection and its regulation on kvl. 2 phosphorylation, we used a specific antisense oligodeoxynucleotide ( odn ) to knockdown the expression of endogenous vegf to observe its role in ischemia / hypoxia cell damage and regulation of kvl. 2 phosphorylation
為了驗證上述假設，本文分別在整體和離體水平，採用大腦中動脈缺血（ middlecerebralarteryocclusion ， mcao ）和體外氧?糖剝奪（ hypoxiaandglucose - deprivation ， hgd ）缺血模型，首先了解了kv1 . 2蛋白的細胞定位及與vegf受體flk - 1和flt - 1的共存情況，觀察了整體mcao后缺血再灌不同時間大鼠腦內kv1 . 2蛋白的磷酸化水平變化，然後通過外源性給予vegf蛋白，在sh - sy5y細胞株上觀察其對缺血細胞存活率及kv1 . 2蛋白磷酸化水平的影響，最後利用vegf反義脫氧寡核苷酸（ oligodeoxynucleotide ， odn ）特異阻斷內源性vegf蛋白的表達，觀察內源性vegf蛋白在缺血細胞損傷及調節kv1 . 2蛋白磷酸化中的作用，以進一步明確vegf缺血保護效應與其調節kv1 . 2蛋白磷酸化之間的關系。 -
The distribution of flt - 1 in this area was similar with that in cerebral cortex, and also has no co - localization with kvl. 2
同樣，在該腦區很少見到flt一1免疫陽性細胞，並與kvl . 2免疫熒光標記不共存。
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