chorionic trophoblast 中文意思是什麼
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Which may provide the molecular basis for the inberine regulation of ll p - hsdl expression by glucocorticoids. secondiy, the regulation of l l 9 - hsdl expression and redutase activity by glucocorticoids was investigated in the primny cultured human chorionic trophoblast
整個妊娠過程中胎盤11 - hsd活性以氧化酶為主，使母體gc在進入胎兒循環前大部分被轉化為無活性的17 -羥- 11 -脫氫皮質酮，保證胎兒正常發育所需的激素濃度。 -
The co - expression of l l6 - hsd1 and gr in the saxne chorionic trophoblast suggests possible intrcrine achons ofglucoconicoid generated by l l6 - hsdl within the cells. 2. ewe radiomctric conversion assay showed that trctrient of the cells with the synthetic glucocorticoid - - dexarnethasone ( l0 - ' m ) for 24h increased the conversion of conisone to cortisol, and thes increase was blocked by the gr antagonist ru486
雙標免疫組織化學染色結果顯示11p hsdi和gr共存於同一個滋養層細胞，提示在體內無活性的gc代謝產物?一17羥d脫氫皮質酮經11p hsdi還原活化后可以直接與同一個細胞內的gr結合，即以內在分泌（ intracrine ）形式發揮作用 -
L lp - hsdl ma of i. 5kb was detected in the rna extracted from cult ' ured chorionic trophoblast using northem blot hybridhation method. the expression of ll6 - hsdl wa was induced by treating the chorionic cells with dexamethasone ( l0 - ', l0 ' m ) for 24h, and the induction was blocked by co - treatinent of the cells with ru486. these results suggest a gr - mediated effect of glucocorticoid on the rnrna expression and reductase activity of l l 9 - hsd1
人h合成的肌?一加x門』 m ）對培養的絨毛膜滋養層細胞的11p hsdi還原酶活性具有誘導作用，此誘導作用可以被gr阻斷劑ru486門0川）所阻斷； northern印跡雜交方法進一步證實， dex亦可誘導絨毛膜滋養層細胞11p叫inrna的表達，此誘導作用也可以被ru486門0叫川）所阻斷 -
Main resuits and conclusions are as follows : 1. after 3 days in culture, some of the chorionic trophoblast clustered together and formed mulh - nuclei syncghotrophoblast cells
主要實驗結果和結論如下1免疫組織化學染色顯示， 11p叫和gr免疫活性樣物質存在於培養的絨毛膜滋養層細胞 -
However, whether glucocothcoids modulate llp - hsd1 expression through a prgnoter dependent mechanism has never been studied. in this study we bo exainined whether 1l9 - hsdl and gr are co - expressed in the sarne chorionic trophoblast
胎盤中兩型酶均存在， 11 - hsd1主要存在於胎膜的絨毛膜滋養層細胞，而11 - hsd2主要存在於胎盤的合體滋養層細胞。
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