dahp 中文意思是什麼

dahp 解釋
羥基嘧啶
  1. In microorganisms and plants the first step in the aromatic acid biosynthetic pathway is the condensation of pep and e4p, with the release of the phosphate of pep and the formation of dahp

    在細菌和植物中,由公共途徑莽草酸途徑以及三個專一性途徑分別合成苯丙氨酸、酪氨酸和色氨酸三種芳香族氨基酸。
  2. The common biosynthesis pathway of aromatic amino acids includes seven steps from dahp to chorismate acid. for the common pathway, 3 - dehydroquinate ( dhq ) synthase ( encoded by arob ), 5 - enolpyruv - oylshikimate s - phosphate ( epsp ) synthase ( encoded by aroa ), and chorisma - te synthase ( encoded by aroc ] are rate - limiting enzymes

    芳香族氨基酸的合成步驟有七步是共同的,亦即從dahp到分支酸的合成步驟,其中脫氫奎寧酸合成酶( arob ) 、 5 -烯醇式丙酮酰莽草酸合成酶( aroa )和分支酸合成酶( aroc )是此代謝途徑的關鍵酶。
  3. So it has increasing commercial demand. escherichia coli and many other microoganism synthesize aromatic amino acids through the condensation reaction between phosphoenolpyru vate ( pep ) and erythrose - 4 - phosphate ( e4p ) to form 3 - deoxy - d - arabinohep tulosonate 7 - phosphate ( dahp ). pep and e4p are limiting substrates for formation of dahp

    大腸桿菌和許多微生物一樣,其合成芳香族氨基酸的起始物是由磷酸烯醇式丙酮酸( pep )和4 -磷酸赤癬糖( e4p )二者縮合形成的3 -脫氧- -阿拉伯庚酮糖酸- 7 -磷酸( dahp ) 。
  4. When both genes were co - expressed in e. coli, the activity of ppsa varied from 2. 1 - 9. 1 fold comparing to control, but the activity of tkta was relatively stable ( 3. 9 - 4. 5 fold ). whatever the two genes were expressed respectively or cooperatively, both could promote the production of dahp, the first intermediate of the common aromatic pathway, but co - expression was more effective on forming dahp and screened ppt - and ptp - as more effective. the results demonstrate that co - expression of ppsa and tkta can improve the production of dahp, and what ' s more, when multigenes co - expressed, the recombinant which has coordinated enzymes activity is optimum

    莽草酸途徑的最優化和整體調控基因csra的敲除正是上述改變的分子基礎,同時也為三種芳香族氨基酸的基因工程菌的構建打下了基礎; 7 .在國內外首次實現了共同途徑限制性底物關鍵酶ppsa刁無『及arog與分支途徑關鍵酶基因phea的串聯高效表達,所構建的重組質粒ptga ,其ppsa 、 tkta 、 arog 、 cm和pd的酶活分別比對照提高了3 、 2 、 2 , 5 、 4 、 2 . 3倍,且其酶活比較協調一致; 8 .將ptga導入到篩選的基因敲除和基因替換菌株大腸桿菌31884 c甲b中,搖瓶發酵證實比以往所構建的基因工程菌株具有較高的phe產量和糖轉化率率,分別為0 . 448 %和22 . 4 % 。
  5. This reaction is catalyzed by dahp synthase, which in microorganisms is also the target for negative - feedback regulation of the pathway mediated either by the pathway intermediate chorismate, or by endproducts phenylalanine, tyrosine and tryptophan

    在大腸桿菌中, arog基因編碼受苯丙氨酸反饋抑制的dahp合成酶同工酶arog ,催化e4p和pep反應生成dahp 。
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