glucocorticoid response element 中文意思是什麼

glucocorticoid response element 解釋
糖皮質類固醇應答成分
  • glucocorticoid : 促糖皮質激素 糖皮質激素
  • response : n. 1. 回答,答復。2. 【宗教】應唱聖歌。3. (因刺激等引起的)感應,反應,反響;應驗;【物理學】響應;【無線電】靈敏度,感擾性;特性曲線。
  • element : n 1 要素;成分;(構成)部分;分子。2 【化學】元素;【數學】元,素;【機械工程】單元;單體;【無...
  1. L l6 - hsd2 is localized to the sppytiotrophoblast of the placenty providing a fimctional barrier protecting the fetus from matemal glucocorticoids. a sequence resembling glucocorticoid response element ( gre ) has been identified in the promoter region of the human l l0 - hsdl gene. glucocorticoids have been shown to induce the expression of 11p - hsdl in the hippomus in vitro " whereas controversial results were obtained in the hepatocyte

    體內至少存在兩型11 - hsd ,在細胞完整的狀態下, 11 - hsd1主要為還原酶,它活化gc的代謝產物17 -羥- 11 -脫氫皮質酮(嚙齒類為脫氫皮質酮)為有活性的皮質醇(嚙齒類為皮質酮) ,而11 - hsd2為氧化酶,它催化皮質醇為無活性的17 -羥- 11 -脫氫皮質酮,因此11 - hsd1加強gc的作用,而11 - hsd2減弱gc的作用。
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