gtpase 中文意思是什麼
gtpase
解釋
紡錘體-
Rab7 mediates transport of proteins from early endosome to late endosome or fusion of early endosome with late endosome, while rab9 mediates the retransport of m6pr from late endosome to trans - golgi network. the gtp / gdp - binding ability and intrinsic gtpase activity of rab proteins make them exist in rab - gtp or rab - gdp status. the switching of rabs between gtp - bound ( active ) and gdp - bound ( inactive ) forms requires other regulatory proteins, including guanosine exchange factor ( gef ), gdp dissociation inhibitor ( gdi ) and gtpase activating protein ( gap ), and lays the foundations of rab function
Rab蛋白家族成員和其他小g蛋白一樣可以結合gtp gdp ，在自身gtp酶的水解作用和其他蛋白（ gef 、 gap 、 gdi ）的調節作用下發生gtp （活化狀態）和gdp （無活性）結合形式的轉變；同時rab蛋白也在膜結合性（ membrane - bound ）和胞漿可溶性（ cytosolic ）之間變化，一個變化過程對應著一個功能循環，接著rab蛋白回到初始狀態參與下一個循環。 -
Over - expression of yggg retarded the cell cycle, on the point after dna partition, resulting in accumulation of diploid as bacteria stop division and sequentially went to death. this appearance is similar to that of the era mutants, including the partially defective in era gtpase activity or the reduced in the synthesis of wild - type era which bacteria become arrested in the cycle at the predivisional two - cell stage
在熒光顯微鏡下細菌形態的變化，以及dapi染色和透射電子顯微鏡觀察， yggg的表達與era突變（使era功能降低時）對細菌分裂的影響有類似之處，即細菌dna合成，子代dna分離后；分裂停滯，形成細菌繁殖受阻時， 2 - 4倍體的出現。 -
The execution of rab gtpase biological functiones is also dependent on some effector proteins
Rab蛋白功能的發揮也需要其他的蛋白存在，即所謂的效應蛋白（ effector ） 。 -
Rab proteins are a family of small molecular weight gtpase of ras superfmaily with characteristic molecular weight about 22 - 25 kd. rab gtpases are expressed in almost all eukaryotic cells, ranging from yeast to drosophila and to human. they are ubiquitously or tissue - specifically expressed and function in all of cellular aspects
Rab蛋白是屬于ras蛋白超家族的小g蛋白（ smallg - proteinorsmallgtpase ） ，分子量大多在22 - 25kda之間，表達于從酵母、果蠅、小鼠到人類等各種真核生物中，發揮著各種各樣的功能；其在酵母中稱為ypt sec4p在高等真核生物中稱為rab 。
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