integrins 中文意思是什麼
integrins
解釋
整合素-
Integrins are of vital importance to all metazoans, from humans to sponges
從人類到海綿，粘合素對所有多細胞動物來說都至關重要。 -
Cell adhesion to surface of the substrate is essential to development of the anchorage - dependent cells. only after adhering to surface followed by spreading can cells develop and proliferate. most synthetic polymers used as orthopaedic matrix substitute present hydrophobicity, which may correlates to the low degree of cell attachment. modification with cell adhesion protein / peptides can be benificial to the cell adhesion on polymers and then affect the cell proliferation and differentiation. cell attachment to substrate is primarily mediated by integrins, a widely expressed family of heterodimeric surface receptors. most extrcellular matrix proteins such as fibronectin, osteopontin, collagen type i, bone sialoprotein and vitronectin contain an arg - gly - asp ( rgd ) sequence which is specific to the fixation of cell membrane receptors like integrin. the main aim of this research is to measure, assess adhesion, proliferation of rabbit marrow stromal cells ( mscs ) on the polymers coated by fibronectin, collagen type i or biotie gen, which includes : ( 1 ) biologic characteristics of rabbit mscs were observed by two types of separating method in primary culture. ( 2 ) adhesion, proliferation and differentiation of mscs cultured on polymers coated with biotiegen were assessed. ( 3 ) also, adhesion, proliferation and differentiation of mscs were assessed on plga film or porous plga substrates coated with fibronectin, or collagen type i respectively. ( 4 ) bone formation was observed on the porous plga substrates coated with collagen type i in vivo. this research aims to give new way to make novel synthetic bone with cell adhesion and high bone induction capabilities
因此將這些蛋白包被、固定到材料表面，觀察骨組織工程種子細胞mscs細胞的粘附、生長特性是本研究的中心環節，並從以下方面進行探討： （ 1 ）採用不同原代細胞分離方法，研究其對mscs細胞的生物學特性影響。 （ 2 ）檢測基因勝肽膠對mscs細胞粘附、增殖及分化的影響。 （ 3 ）分別採用型膠原及纖維粘連蛋白（ fibronectin ， fn ）包被聚乙醇酸-乳酸共聚物（ poly （ 1actide - co - glycolide ） ， plga ）膜及多孔塊型plga材料，觀察細胞在單層或三維培養狀態下，型膠原及fn對mscs細胞粘附、增殖及向成骨細胞分化效應及能力。 -
Integrins recognize cues encoded by the extra - cellular matrix and convert them into complex biochemical signals that control the behavior of cells
它通過介導復雜的信號通路，將細胞外信息內傳，調控細胞的生命活動。 -
Integrins, a large family of receptors that attach cells to the matrix, exert an extraordinary control on cell adhesion, migration, proliferation and survival
摘要細胞外基質受體整合蛋白全方位影響細胞的形態、運動、存活和增殖。 -
The interaction of integrins with extracellular matrix has been shown to be mediated through an arginine - glyclne - aspartic acid ( rod ) sequence within adhesive proteins
這說明sz2通過對ntegfin6 。的抑制和誘導凋亡的作用表現了抗血管新生的能力。 -
Being a kind of adhesion molecules associating cells with extracellular matrix, integrins play a variety of roles in the process of invasion and metastasis in pancreatic adenocarcinoma
胰腺癌手術切除率低死亡率高的重要原因之一是腫瘤早期即能發生局部浸潤和遠處器官轉移，整合素作為細胞與細胞外基質的黏附分子，在胰腺癌侵襲及轉移過程中發揮多重作用。
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