intracellular receptor 中文意思是什麼

intracellular receptor 解釋
細胞內受體
  • intracellular : adj. 細胞內的；發生於個體細胞內的。
  • receptor : n. 【生物學】感受器；受體；【化學】接受器；受納體；【電學】感受器；接收器。
  1. Our previous studies showed existence of apoplast cam in the plant cell and cam had many extracellular functions. so it supposed cam may be one of important extracellular polypeptides and trigger the intracellular signal transduction by binding the receptor. in this study, radiolabelled ligand is used to investigate the binding characteristic of cam and a. thaliana protoplasts. and chemical crosslinking is employed to explore binding proteins in the membrane. at first, ( 35 ) ~ s - cam was produced using ( 35 ) ~ s - labeled amino acid mixture in e. coli. sds - page and autoradiograph indicated high - purified, high - specific radioactivity ( 35 ) ~ s - cam was obtained. electrophoresis of ( 35 ) ~ s - cam is the same as that of unlabeled cam with ca ~ ( 2 + ) or egta ; a quatitive of protoplasts was prepared by enzymolysis

    首先，用~ （ 35 ） s標記的氨基酸混合物喂養工程菌成功地制備了~ （ 35 ） s標記的擬南芥鈣調素（ ~ （ 35 ） s - cam ） ， ~ （ 35 ） s - cam純度高、放射活度高、 ca ~ （ 2 + ）與egta存在時的電泳行為與未標記cam相同，可作為一種高靈敏性的探針用於進行受體學分析實驗；用擬南芥種子誘導愈傷，通過酶解制備了大量原生質體。
  2. For example, the signal transduction of g protein - coupled receptor is mediated by g protein and can generate intracellular messages ; there exist some transmembrane proteins in the membrane of endoplasmic reticulum, and some of them are related with the synthesis and transportation of some proteins, while others are related with substance metablism, such as glucose - 6 - phosphatase ( g6pase ). in addition, after binding with the 7 - tm receptors affiliated to frizzled protein family, wnt can activated disheveled protein in cytoplasm which is essential to embryonic development

    如g蛋白偶聯受體通過g蛋白介導產生胞內信使（ camp ， cgmp ， dg ， ip _ 3 ）將胞外信號傳遞到胞內，從而引起生物學效應；內質網上也存在著一些跨膜蛋白，其中一些與蛋白質的合成及運輸有關，一些與物質代謝有關，如葡萄糖- 6 -磷酸酶。
  3. Ricin enters the cells by receptor - mediated endocytosis, followed by translocation across the membranes of intracellular compartments

    蓖麻毒素具有強烈的細胞毒性，具有抗腫瘤的應用前景。
  4. The purposes of the present study were to investigate ( 1 ) the hemodynamic effects of agmatine in anaesthetized dahl salt - sensitive ( ds ) hypertensive and dahl salt - resistant ( dr ) rats ; ( 2 ) the effect of agmatine on vascular tension in the isolated aortic artery of rats and the underlying receptor mechanism ; ( 3 ) the effects of local injection of agmatine on femoral, renal, and mesenteric vascular beds by constant flow perfusion method ; ( 4 ) the effect of agmatine on l - type calcium current ( / ca - t ) in rat ventricular myocytes with whole - cell configuration of the patch - clamp technique ; ( 5 ) the effects of agmatine on free intracellular calcium concentration ( ca2 + d of isolated rat ventricular myocytes

    （ 3 ）採用後肢、腎臟和腸系膜動脈在體恆流灌注法，觀察向灌流環路中直接注射胍丁胺的血管效應。 （ 4 ）應用全細胞膜片箝技術，觀察胍丁胺對大鼠心室肌細胞l -型鈣通道電流（ i _ （ ca - l ） ）的影響。 （ 5 ）用fluo3 - am負載分離的大鼠心室肌細胞后，由激光共聚焦法測定單個心室肌細胞[ ca ~ （ 2 + ） ] _ i的熒光強度，觀察胍丁胺對分離大鼠心室肌細胞內游離鈣濃度（ [ ca ~ （ 2 + ） ] _ i ）的影響。
  5. A c a2 + / calmo dul in - dep endent pro te in kinas e i i ( c amkii ) antagoni st kn - 6 2 ( 5x l0 - ' mol / l ) presented in the intemal solution had no significan effect on the current peaks induced by extracellular nmda ( l0 # mol / l ), but prevented the inhibitory effect of b on inmda " these results indicate that gcs have rapid, reversible idebitory effects on lnmda intracellular application of b thiough microelectrode had no effect on inmda, howevet, extracellular application of b or b - bsa suppressed peaks of inmda : all these denote b exerts its influence on nmda receptor by cytoplasm membrane mechansms, which is naxnely rapid, nongenomic mechhasms

    加有快速、可逆的。非濃度依賴性抑制作用。通過微電極將b直接導入細胞內， inmda不受影響，而胞外給予b或besa ， inmda減小，提示b對nmda受體的調控通過膜機制產生，這種作用與經典的基因組機制不同；因為廣譜激酶抑制劑和特異的pka抑制劑均可翻轉b的抑制效應， camk11抑制劑也可阻斷b的效應，而這些激酶抑制劑本身對inmda即有強烈的抑制作用： pka激動劑本身對inmda無明顯作用，也不影響b對l 。
  6. This hypothesis provide a new thinking on the action of steroid hormone on neurons, and is both a challenge and a supplement to the traditional genomic theory, which held that the action of steroid hormone is solely mediated by its intracellular cytosolic receptor within the cell nucleus

    年代首次在國際上提出糖皮質激素作用於神經元的快速、非基因組機制或膜受體假說。這是對傳統崽體激素基因機制或細胞學說的挑戰與補充，受到國際學術界的高度評價，曾應邀在第
  7. A single molecule of rta is able to depurinate 1500 - 2000 ribosomes per minute. ricin b chain ( rtb ) is a galactose - specific lectin which binds to the receptors on cell surfaces, and may enhance rta translocation by forming a pore in the membrane of intracellular organelles. ricin enters the cells by receptor - mediated endocytosis

    內吞進入細胞的蓖麻毒素一部分返回到膜表面，一部分經早期內體至晚期內體，最後在溶酶體中降解，只有一小部分約5到達高爾基體，隨后逆轉運到粗面內質網，在那裡rta才和rtb解離，游離出有催化活性的rta 。
  8. It is known from studies using brefeldin a ( bfa ) that disruption of tgn can block the cytotoxicity of ricin, suggesting that the intracellular compartment may be an important part of the uptake pathway. ricin enters the cells by receptor - mediated endocytosis, followed by translocation across the membranes of intracellular organelles. in this study, a trans - golgi retention peptide signal yqrl was fused to the c - terminus of ricin a chain ( rta ) by polymerase chain reaction

    本實驗為重點研究反式高爾基體在毒素細胞內轉運過程中的作用，我們設計了一個反式高爾基體的靶向信號肽基因yqrl （ tyr - gln - arg - leu ）連接在rta分子的羧基端，用原核表達蛋白體系，純化並測定rta - yqrl與rta蛋白對hela （人宮頸癌細胞） ， wish （人羊膜上皮細胞） ， skov - 3 （人卵巢癌細胞）三種細胞的毒性作用。
  9. The npr - c is a membrane - bound receptor that lacks the intracellular guanylate cyclase domains of the biologically active receptors and is therefore uncoupled with cgmp. npr - c functions as a clearance receptor by binding with and internalizing natriuretic peptides. nprs are widely and differently distributed in most tissues and can be up - or down - regulated in many pathological processes, which indicates that they have different effects on different tissue and participate in the regulation of their physiological and pathological process

    正常情況下，三種受體在體內均廣泛分佈，但在不同組織中的分佈有很大差異，而且在不同病理條件下鈉尿肽受體數目還可發生上調和下調，提示鈉尿肽家族及其受體對不同組織器官的作用不同，並參與它們的生理和病理過程的調節。
  10. Trka, the high affinity ngf receptor, contains an intracellular domain with tyrosine kinase activity and an extracellular domain with three tandem leucine - rich motifs flanked by two cysteine clusters in their amino termini and two immunoglobulin - like domains in the more membrane - proximal region

    膜外域含有8個亮氨酸的重復區域，其前後分別串聯著一組半胱氨酸殘基，緊挨細胞膜的是兩個c2 -型免疫球蛋白樣區ig和ig ；膜內域為酪氨酸激酶催化活性區。
  11. Pretreatment with the phospholipase c inhibitor u73122 ( 5 umol / l ) significantly inhibited the il - 2 - induced depression of contraction. conclusion : it is concluded that the effect of il - 2 on contraction of ventricular myocytes is mediated via the cardiac k opioid receptor, and the post - receptor signal transduction pathway includes a ptx sensitive g protein and phospholipase c. 2 effect of interieukin - 2 on intracellular calcium tran

    5 200u ffil ）濃度依賴性地降低單個心室肌細胞電刺激誘導的鈣瞬變幅度，使舒張末鈣水平升高； （ 2 ） il 2 （ 200u ml ）使咖啡因誘導的肌漿網內貯鈣的釋放降低： （ 3 ） 50偷i熱失活！
  12. Both spla 2 and ceramidehave been shown to inhibit bradykinin -, and pma - induced phospholipase d activation. these results indicated the existence of a subtle intertwined regulatory interaction between intracellular phosphoglycerol lipids and sphingolipids signaling pathways. in addition, we also found that spla can 2 down regulate theepidermal growth factor ( egf ) receptor activation

    此外，我們還發現分泌型磷脂酶a能下調表皮生長因子受體的活化，它能明顯的抑製表皮生長因子誘導2的受體自身磷酸化，並抑製表皮生長因子誘導的磷脂酶d活性和磷脂酶c - g的1酪氨酸磷酸化。
  13. Some trends in the studies of cellular inorganic chemistry have been described in this review, which mainly contains the aspects of effects of metal ions including calcium ions and lanthanide ions and activated small molecule on ion channels, receptor proteins in the membrane, intracellular receptor proteins and cellular function

    摘要本文評述了當前細胞無機化學研究中的幾個方面，主要是包括鈣離子和稀土離子在內的金屬離子和活性小分子對細胞膜離子通道、膜受體蛋白、胞內受體蛋白以及對細胞功能的影響。
  14. The members of src family are non - receptor tyrosine kinases. their make an important function in a complex network of intracellular signals, such as cell growth, proliferation, transformation, apoptosis, and cell adhesion, migration. the fact that src was discovered as an oncogene suggests that src could closely involvement in cancer

    而今， src已發展成為包括九個成員在內的激酶家族，隸屬于非受體酪氨酸激酶，是細胞信號轉導途徑中一類重要的信號分子，調控細胞的生長，增殖，凋亡，細胞黏附與遷移等一系列功能。
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