p-glycoprotein 中文意思是什麼
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Mdr1 express product p - glycoprotein was detected by immunocytochemical method and flowcytometry. the cytotoxicity and multidrug resistance reversion effect of tea polyphenol was examined by mtt assay in mcf - 7 and mcf - 7 adr carcinoma cell lines, and compared with pgp inhibitor quinidine. the pgp expression of mcf - 7 adr was strongly positive, the positive rate was 15 % ; the pgp expression of mcf - 7 was negative, the positive rate was 1. 8 %. ic50 of tea polyphenol to mcf - 7 and mcf - 7 adr is 115. 2g ml and 207. 6g ml respectively. ic50 of quinidine to mcf - 7 and mcf - 7 adr is 129. 8mol l 42. 1g ml and 94. 1mol l 30. 5g ml respectively. tea polyphenol and quinidine changed little toxicity of adriamycin to mcf - 7, but tea polyphenol and quinidine improved the sensitivity of mcf - 7adr to adriamycin significantly. immunocytochemistry and flow cytometry can detect p - glycoprotein expression level qualitatively and quantitatively. tea polyphenol is not only an anti - tumor agent, but also a multidrug resistant modulator similar as quinidine. tea polyphenol is advantageous for its little toxicity in tumor treatment
用免疫組化法和流式細胞儀對腫瘤細胞系mcf - 7和mcf - 7 adr的p -糖蛋白表達水平進行定性定量研究。用噻唑藍比色法mtt研究茶多酚的細胞毒性及其對耐藥性的逆轉作用，並與pgp抑制劑奎尼定進行了比較。免疫組化法檢測p -糖蛋白表達水平， mcf - 7 adr呈強陽性，而mcf - 7呈陰性流式細胞儀定量檢測結果mcf - 7 adr細胞系細胞陽性率為15 % ， mcf - 7細胞系細胞陽性率為1 . 8 % 。 -
Research on structure - activity relationship of inhibitory effects of flavonoid derivatives on p - glycoprotein
糖蛋白抑制劑的構效關系研究 -
Reversal of p - glycoprotein mediated multidrug resistance by traditional chinese medicines
17逆轉腫瘤細胞多藥耐藥性的研究 -
Holzmager ta, hilsenback s, von hoff dd, et al. clinical correlates of mdr1 ( p - glycoprotein ) gene expression in ovarian and small - cell lung carcinoma [ j ]. j natl cancer inst, 1992, 84 : 1486
陳曉耕，王清水，陳新，等.多藥耐藥基因產物表達和細胞凋亡對胃癌影響的研究[ j ] .中華腫瘤雜志， 2000 ， （ 22 ） 6 : 488
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