proband 中文意思是什麼
proband
解釋
n. 名詞 家譜中發支始祖 （＝propositus）。-
One missense mutation was found in 48 hypertriglyceridemic patients and identified to be pro207 - leu by sequencing, pedigree analysis of this proband has been carried out and showed that the pro band ' s father is also a carrier of this mutation
徵得患者家屬的同意和支持，對其家族三代十人進行了完整的家系分析。家系分析顯示，先證者的突變來自其父親的遺傳。在外顯子6 、 7 、 8中未檢出基因突變。 -
Heredity modes of 6 traits were studied by analysis of population genetics, by the method of family combination analysis, by the methods of proband ' s sib analysis, segregation analysis, the threshold model of polygenes, and analysis of typical family trees, according to the data of the 72 families. the relative importance between genetic and environmental effect on each character was evaluated by comparing the coherence of twins. gene frequencies of 5 genetic characters, calculated from han group in huhhot, were compared with other groups by u - test so as to study the population or nationality difference in heredity
採用群體遺傳學分析、家系組合分析法、先證者同胞法、分離分析法及多基因閾值模式分析方法對所得家系資料進行了統計學分析，結合家繫系譜分析探討了上述6項特徵的遺傳方式；通過雙生子一致率的比較，對上述特徵的遺傳與環境效應的相對重要性進行了評價；計算了呼和浩特市漢族群體5對遺傳性狀的基因頻率，採用u檢驗方法與相關文獻報道的其他群體進行了比較，探討了不同種族間或民族間的遺傳差異性。 -
The individuals of rhd - positive phenotype with intact exons carried generally insert fragments and boxl box2 and box3 and this proved that inserts or rh box could n ' t affect the express of rh d gene. in 2 of the 5 wei nationality pedigrees whose proband were rh d - negative, rhc / e phenotype of all the rh negative individuals was ccee. rhd exon 4nsert and rh box did not be found in all individuals
在7個先證者為rhd陰性的漢族家系中，大部分成員均出現插入片段和rhbox ，且在遺傳上符合孟德爾遺傳定律， d外顯子完整且表型為rhd陽性的家系個體成員廣泛帶有插入片段和box1 、 box2或box3 ，插入片段或rhbox並未影響d基因的表達。 -
In 82 cases of rh d serology negative individuals with rh c / e typing for cc or cc was 20, of which 9 carried intact exons, 6 carried partial deletion exons, and 5 was total deletion. ( 3 ) inseit fragments and rh box were detected in most of cases in 7 han nationality pedigrees which proband were rh d - negative, and intheritance accorded with the mendel ' s law
檢測82例rhd血清學陰性個體中， c e型為cc或cc有20例，其中完整攜帶rhd基因外顯子者為9例，部分攜帶者為6例，完全缺失者為5例。 -
To study on structure and inheritance of rh d gene interaction between gene expression of rh d and rh c / e and influences on rh d gene expression of inserts and rh box - methods : 20 pairs of oligonucleotide specific primers for exon, intron 2 4, insert and rh box of rh d, rhc / e gene were designed and composed the polymerase chain reaction - sequence specific oligonucleotide primer ( pcr - ssp ) was used to amplify the rh c / e gene, rh d gene, exon, intron, insert and rh box in 106 samples of unrelated individuals and 7 han nationality ancestries and 5 wei nationality ancestries whose proband were rh d - negative
目的：觀察中國漢族非血緣關系隨機個體、漢族及維吾爾族家系rh血型的c e基因、 d基因外顯子、內含子、插入片段以及rhbox ，研究rhd基因結構及遺傳規律， d基因表達與c e基因的關聯，以及插入片段和rhbox對d基因表達的影響。
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