receptor guanylate cyclase 中文意思是什麼
receptor guanylate cyclase
解釋
鳥苷酸環化酶-
However, there i s no direct evidence about the influences of vnp on the proliferation of other vascular smooth muscle cells. three receptors subtypes for natriuretic peptides have been identified, the natriuretic peptide receptor ( npr ) - a, npr - b and npr - c. the npr - a and npr - b are membrane - bound guanylate cyclase coupled to production of 3 ", 5 ' - cyclic guanosine - 7 - monophophate ( cgmp )
鈉尿肽受體（ natriureticpeptidereceptors ， nprs ）有a 、 b 、 c三個亞型，其中a 、 b （ npr - a 、 b ）受體是鳥苷酸環化酶（ gc ）耦聯受體，與配體結合后引起細胞內cgmp水平升高，而c受體不與gc耦聯，主要通過結合和內化（ internalize ）鈉尿肽而發揮清除受體的功能。 -
The npr - c is a membrane - bound receptor that lacks the intracellular guanylate cyclase domains of the biologically active receptors and is therefore uncoupled with cgmp. npr - c functions as a clearance receptor by binding with and internalizing natriuretic peptides. nprs are widely and differently distributed in most tissues and can be up - or down - regulated in many pathological processes, which indicates that they have different effects on different tissue and participate in the regulation of their physiological and pathological process
正常情況下，三種受體在體內均廣泛分佈，但在不同組織中的分佈有很大差異，而且在不同病理條件下鈉尿肽受體數目還可發生上調和下調，提示鈉尿肽家族及其受體對不同組織器官的作用不同，並參與它們的生理和病理過程的調節。
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