t-cell activation antigen 中文意思是什麼
t-cell activation antigen
解釋
細胞激活抗原-
T cell will be apopotosis, clone depletion and / or anergy, in turn inducing an antigen - specific tolerance. ctla4 ( cytotoxic t lymphocyte associated antigen 4 ), a prominent negative costimulator, can competitively bind with b7, and block b7 - cd28 pathway and t cell activation by producing inhibitory singals
Ctla4 （ cytotoxictlymphocyteassociatedantigen4 ）作為一種主要的共刺激負調節劑，可競爭性結合b7分子，阻斷b7 - cd28途徑、並通過產生抑制性信號使t細胞活化障礙。 -
Dendritic cells ( dc ) is the most powerful apc, which can markedly increase the antigen - presentation capacity by maximizing the pepitide - mhc complexes on the cell surface and upregulating the co - stimulatory ligands b7 - 1 and b7 - 2, adhesion moleculees such as il - 12 that promote full activation of lymphocytes. full activation of antigen - specific t cells requires two signals - one signal coming via the tcr and the other signal through engagment of co - stimulatary molecules. t cells receiving one signal via their tcr are turned off by mhc ( major histocompatibility complex ), via t cell cd28 binding to b7 on the dc induce tlymphokine and t cell proliferatiion
T細胞介導的細胞免疫在控制腫瘤生長方面發揮著重要作用， t細胞在發揮抗瘤效應（分泌細胞因子和直接殺傷）之前必須先經過活化，體內專職抗原提呈細胞（ apc ）細胞並使其活化，樹突狀細胞（ dendriticcell ， dc ）為t細胞的激活提供雙重信號， t細胞藉助tcr識別由dcmhc分子遞交的抗原肽后，通過tcr - cd3復合體傳遞抗原特異性識別信號（第一信號） ，以cd28為主的t細胞表面輔佐分子識別dc表面b7分子，傳遞非特異性協同刺激信號（第二信號） ，在機體抗腫瘤免疫應答中處于核心地位。 -
Effective activation of antigen - specific t cells not only requires the first signal transduction through t - cell receptor ( tcr ) binding with peptide - mhc complex on the antigen presenting cell ( apc ), but also needs the second signal, termed costimulation. costimulation critical to the degree and consequence of t cell activation is provided by interaction between soluble factors or cell - surface molecules on the t cell and on the apc
而t細胞的活化除需要t細胞受體（ tcr ）與抗原呈遞細胞（ antigenpresentingcell ， apc ）表面的抗原肽- mhc復合物結合所形成的第一信號外，還需要t細胞和apc表面的其它膜分子結合所提供的共刺激信號（亦稱第二信號或輔助刺激信號， costimulatorysignal ）的參與。 -
Cd226, also named platelet and t cell activation antigen 1 ( ptal ), was discovered by burns in 1985. pta1 mainly expressed on activated t cell, nk cell, megakaryocyte and platelet. previous study indicated that il - 2, tnf - a and pma could upregulate the expression of pta1 on t lymphocytes and tgf - p down - regulate its expression
Cd226又稱為血小板和t細胞活化抗原1 （ plateletandtcellactivationantigen1 ， pta1 ） ，最早在1985年由bums等發現，主要表達于活化t細胞、 nk細胞、巨核及血小板譜系，參與t細胞的活化與分化以及血小板的活化和聚集。
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