telomeric 中文意思是什麼
telomeric
解釋
末端著絲粒的-
2. 4 affymetrix moe430a genechip analysis of expression pattern differences of undifferentiated escs and neural induced cells. 2. 5 telomeric repeat ampliation protocol ( trap ) assays
2 . 4採用月升metrixmo以30a小鼠表達譜晶元進行未分化及分化后第4 、 10天細胞基因表達譜差異的分析。 -
Conversely, however, it may be an underestimate, since cell division is faster in the fetus and neonate than in the adult and since the gene most often mutated in dc, dkc1, seems to have a nucleolar as well as telomeric function
然而，相反地， （ 10年）可能是一種低估，因為在胎兒和嬰兒中，細胞分裂快于在成人中，還因為在dc 、 dkc1中經常突變的基因，似乎有核仁和端粒的功能。 -
Telomerase is a ribonucleoprotein complex ( rnp ) composed by its rna component and protein subunits. telomerase can synthesize telomeric dna onto chromosomal ends using its own rna component as a template, elongate the length of telomere, increase cell life and even induce cell immortalization
端粒酶（ telomerase ）是由端粒酶rna和蛋白質組成的一種核糖核蛋白復合物（ rnp ） 。端粒酶含有引物特異識別位點，能以自身rna為模板，逆轉錄合成端粒dna並加到染色體末端，使端粒延長，從而延長細胞的壽命甚至使其永生化。 -
Telomerase is a celler reverse transcriptase which catalyzes the synthesis and extension of telomeric dna. telomerase activation is not observed in normal tissues of somatic origin but in almost 90 % of human cancer, with the result the telomere shorten progressively with cell division and thus is a critical step for multistep carcinogenesis
正常人體細胞（非生殖細胞）中端粒酶活性的表達很低，或用目前的方法幾乎檢測不到，而在90以上的惡性腫瘤中可檢測到端粒酶活性，相應的良性腫瘤則為陰性或僅有少數陽性。 -
We concluded that excessive expression of exogenous htr gene may compete with the endogenous telomerase rna and prevent rna template from combining with telomeric dna, thus repressing the elongation of telomeric dna ( telomeres ) and causing cell aging and cell death. - 6 - 3. some modifications have been made to overcome the limitation of conventional telomeric repeat amplification protocol ( trap ) assay
分析其原因，可能是htr基因的過表達在數量和空間效應上同細胞內的端粒酶rna組分產生竟爭，一定程度上阻礙了端粒酶rna模板區與端粒dna的結合，從而抑制端粒dna的延伸，導致細胞凋亡。
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