terminal amino group 中文意思是什麼
terminal amino group
解釋
端胺基-
The experimental method includes selecting pure complexes of histidine - containing or cysteine - containing materials, from c - and n - terminal group of these amino acids to link to a group which have color or fluorescence or ultraviolet absorption, elucidating their binding affinity, fluorescence or uv - visible spectrum properties with zinc at physiological concentration and to elucidate their structure in the solid state via infrared spectroscopy. with the help of the concerned the data, the analysis was done to prove whether it can be applied to the zinc detection, in other words, whether it can be used as a new fluorescence probe for zinc detection
本實驗首次選用在生物體內與zn ~ （ 2 + ）鍵合能力很突出的物質? ?組氨酸和半胱氨酸，採用類似於多肽合成的方法，在其羧基或氨基分別嫁接上一個帶有標記的基團，生成穩定的共價鍵化合物；在此化合物中模擬生理濃度條件加入鋅離子，通過紅外圖譜、紫外圖譜或熒光圖譜的變化分析鋅離子對標記基團是否產生影響，再結合有關數據分析其是否適合檢測鋅離子，即是否可能作為新的鋅離子熒光探針。 -
The pocket accommodating the aromatic ring of phenylalanine is formed predominantly by hydrophobic side - chains, including those of ile10, ile13, prol50, leul75, leul79, phe209, ser211 and val221 ; whilst the amino group and carboxylate group of phenylalanine is coordinated by asp6, asp7, gln151 and ser180. the n - terminal region is found to be important to the function of arog. point mutation reveals that residue substitution of ilelo to ala10 leads to desensitization in the presence of 1 mm phenylalanine, simultaneously, exhibits a dramatic decrease in enzymatic activity
綜合前人的研究和本研究工作的實驗數據，得出以下結論： 1 ）在arog的反饋抑制位點供苯丙氨酸結合的疏水口袋由asp6 、 asp7 、 ile10 、 ile13 、 pro150 、 gln151 、 leu175 、 leu179 、 ser180 、 phe209 、 ser211和val221等12個氨基酸殘基構成； 2 ）苯丙氨酸結合的疏水口袋分為兩個區域，與苯丙氨酸的苯環發生疏水作用的區域由ile10 、 ile13 、 pro150 、 leu175 、 leu179 、 phe209和val221的側鏈構成，而asp6 、 asp7 、 gln151和ser180的側鏈構成了與苯丙氨酸的氨基和羧基相互作用的區域。
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