tgf 中文意思是什麼

We showed here that axudl mrna expression was elevated by tgf - 1 treatment in a time and dose - dependent manner in hepg2 hepatoma cells and spc - a1 lung carcinomas cells, and also indicated that de novo protein synthesis was required for this response using the protein synthesis inhibitor cycloheximide, suggesting that axudl is a primary target of tgf - signalling

在hepg2和spc - a1細胞中， tgf - 1能明顯誘導這兩種細胞中的axud1基因的表達，而且表現出時間和濃度的依賴效應。同時，利用第一軍醫大學博士學位論文蛋白質合成的特異抑制劑還發現， tgf一pl誘導的axudl基因的表達過程需要新的蛋白質的合成，提示axudl基因是tgf一p信號通路的一個主要靶分子。

In addition, axud1 has a high homologue with transforming growth facotr beta ( tgf - ) induced apoptosis protein 2 and 12 using blast exploration at genebank database. these suggest that axudl may have a tumor - suppressor function in these organs and may play an important role in tgf - - induced apoptosis

通過genkbank上blast的搜索結果表明， axud1與tgf -誘導的凋亡蛋白2 、 12 （ taip - 2 、 taip - 12有較高的同源性，提示axud1可能是一個具有腫瘤抑制功能的基因，並可能在tgf -誘導的細胞凋亡中起著重要作用。

Results pulmonary coefficient was significantly lower in all the drug intervening groups than that in the model group p0 05, improvement on alveolitis and pulmonary fibrosis were also shown after intervention, especially in the hxd prevention group pwtbz005. hyp content in lung tissue and tgf 1 content in balf lowered at the same time

結果各藥物干預組與bm組比較，小鼠肺系數明顯下降p005肺泡炎纖維化程度均有改善p005 ，其中化纖湯預防治療組改善最明顯肺hyp含量下降p005 balf中tgf 1含量亦明顯下降。

Tgf - and simultaneous immune suspression of keratoplasty

與角膜移植誘導的免疫耐受

Expression of tgf - 1 in acoustic neuroma and its correlation to tumor angiogenesis

1的表達及其與腫瘤血管形成的相關性

Observation of salvianolic acid b on rat tgf 1 - stimulated cultured hepatic stellate cells

1刺激的大鼠肝星狀細胞的觀察

Pulmonary fibrosis was induced in the model group by intranasal instillation of bleomycin 5 mg kg. hxd were given via gastrogavage to the hxd prevention group and treatment group respectively at 48 h before and 14 days after they were modeled with the same method, and the groups of ligustrazin and prednisone, treatment and prevention, were managed the same as for hxd groups, but with ligustazin and prednisone instead of hxd respectively. bronchoalveolar lavage fluid balf and lung tissue of animals were gathered on day 28 cellular ultrastructural changes of lung was examined under electron microscope by he, masson stain ; content of hydroxyproline in lung tissue was assessed by acidolysis method ; and concentration of transforming growth factor 1 tgf 1 in balf was assessed by elisa

方法68周雄性icr小鼠分8組，模型組bm組經鼻滴入博萊黴素blm 5 mg kg建立肺間質纖維化模型，化纖湯預防治療組pht組于滴入blm前48 h予化纖湯灌胃，化纖湯治療組ht組于滴入blm后第14天用化纖湯灌胃，同時設立丹參預防治療組pdst組及丹參治療組dst組，地塞米松預防治療組pdt組及地塞米松治療組dt組，並與正常小鼠nc組進行對照。

Follistatin, a kind of secreted protein, is known to antagonise the function of several members of the tgf - beta ( transforming growth factor - beta ) superfamily including myostatin, the most powerful inhibitor of muscle growth characterised to date

卵泡抑素（ follistatin ）是一種分泌蛋白，它可以拮抗tgf - beta （ transforminggrowthfactor ，轉化生長因子）超家族中幾種成員的功能，包括myostatin 。

Human bone morphogenetic protein 3 is a member of tgf - b superfamily. lt can induce the differentiation of cartilage and bone tissue in mesenchymal cell. and is important to bone self - repairment and bone development during embryo morphogenesis. in addition, some other biological activities of hbmp - 3 have also been found. such as inducing development of embryo and stimulating differentiation of neural and blood cells. therefore, there is a great prospect in the use of hbmp - 3. there is trace content of hbmp - 3 in human body. it has been expressed in the expression system of eukaryotes and prokaryotes respectively, but its application is restricted because of defects in the process and modification after translation in prokaryotic cells and higher costs and lower yields existed in eukaryotic expression system

人骨形成蛋白3 （ hbmp - 3 ）屬于tgf -超家族的一員，可以誘導間充質細胞分化為軟骨和骨，在胚胎時期骨骼發育和骨再生修復中起著重要的作用，而且對胚胎發育過程中中胚層的誘導和分化、造血組織的發育以及神經系統的發育和修復等都起著重要作用，因而hbmp - 3有廣闊的市場前景。它在人體內含量極微，盡管研究人員已經在原核細胞和真核細胞表達系統中分別進行了表達，但是由於原核表達系統缺乏翻譯后的加工修飾，真核表達系統存在成本高、產量低等特點，限制了其在臨床上的應用。

Levels of fasting blood glucose and 24h urinary microcontent of albumin 24 h malb were determined dynamically ; the serum glycosyl hemoglobin hba1c was determined after the last medication ; the ultrastructural changes of kidney were observed by transmission electron microscope ; the expressions of collagen, fibronctin, laminin ln, and the ecm metabolism influencing factors, including mmp2, tissue inhibitor of metalloproteinase timp2, transfer growth factor 1 tgf 1 in renal tissue were detected by immunohistological chemistry and image collecting analytical system

動態檢測各組大鼠空腹血糖fbg 24h尿微量白蛋白24h malb ，末次給藥后測定大鼠血漿糖化血紅蛋白hba1c透射電鏡觀察各組大鼠腎臟超微結構改變，應用免疫組化技術及圖像採集分析系統測定各組大鼠腎臟組織中型膠原c纖維連接蛋白fn層粘連蛋白ln的表達，測定影響ecm代謝的基質金屬蛋白酶2 mmp2基質金屬蛋白酶抑制劑2 timp2及轉化生長因子1 tgf 1的表達。

Transforming growth factor, tgf

目的明確大腸癌細胞在轉化生長因子

Experimental study of tgf - 2 antisense oligodeo - xynucleotide as an anti - scarring agent in glaucoma surgery

2反義寡核苷酸抑制抗青光眼術后濾過泡瘢痕的實驗研究

During the development of liver in alligator sinensis embryos, ss - ir cells appeared in a few of sinusoid endothelial cells on 8th day. 5 - ht - ir blood cells and tgf p 1 - ir blood cells were found in vein vessel from 30 - 55th day. egf - ir cells and sp - ir cells appeared in the outer membrane of liver from 40 - 55th day

揚子鱷胚胎肝臟中，生長抑素免疫陽性細胞出現于孵育第8天肝血竇內皮細胞間；孵育第30 ? 55天，靜脈血管中發現5 ?羥色胺陽性血細胞和tgf 1陽性血細胞；表皮生長因子陽性細胞和p物質陽性細胞僅在第40 ? 55天出現于肝臟外被膜；甲胎蛋白免疫陽性細胞在第55天出現于肝臟外被膜及靠近外被膜的血管內皮。

The effects of protein kinase c in tgf - 1 stimulating proliferation and collagen synthesis of normal and hypertrophic scar fibroblasts

粉防己堿對兔瘢痕組織作用的實驗研究

Effect of tgf - on the proliferation and differentiation and gene expression in rat osteoblast

補骨脂提取物對體外培養新生大鼠顱骨成骨細胞的影響

However, only c - myc protein was slightly increased in cells transfected with vector alone and other proteins expression level were the same as conditions in the absence of tgf - 1. in addition, hepg2 cells transfected with pcdnas. 1 / ha - axudl plasmid were arrested in gl phase compared with the cells transfected with vector alone

另外，流式細胞儀檢測表明， ha一axudi蛋白的過表達細胞組較空載體轉染細胞組， g0 / g1 （ % ）上升，而s （ % ）下降，說明細胞阻滯于g1期。

In order to further investigate the role of axudl in human tumor carcinogenesis and the potential association between the axudl gene expression status and the stimulation of transforming growth factor beta in human cancers, the present study was performed in three aspects as follows : ( 1 ) cloning full length enconding region cdna of axudl and construction of eukaryotic vector that expression the fusion protein of axud1 and influenza virus hemagglutin ha epitope tag ; ( 2 ) exploring the time and dose effects of tgf - 1 on the expression - of axudl gene in hepg2 hepatoma cells and spc - a1 lung carcinomas cells, and studying the effects of overexpression of axud1 on the expression of cell cycle and apoptosis related protein in hepg2 hepatoma cells ; ( 3 ) construction and expression of human axudl in e. coli m15. the following main results and conclusions can be obtained from the present study : 1. the full length ecnoding region of human axudl cdna from human peripheral blood lymphocytes was successfully cloned using one step rt - pcr method, and constructed into a eukaryotic expression vector which can be expressed a ha - axud1 fusion protein with axud1 and influenza virus hemagglutin ha epitope tag. the recombinant plasmid was identified by polymerase chain reaction, restriction endonuclease maping and sequencing, this expression vector might be instrumental to further study the function of axud1 protein in tumor cells

為了進一步研究axud1在人類腫瘤發生中的作用及axud1基因的表達狀況與tgf -介導的信號通路的關系，本實驗研究分為三個部分： （ 1 ） axud1基因cdna全長編碼區的克隆和ha表位標記的axud1基因表達載體的構建； （ 2 ）探討肝癌細胞hepg2和肺腺癌spc - a1細胞中tgf - 1誘導的axud1基因表達的時間、劑量效應以及誘導表達的可能機理，並研究axud1的過表達對細胞周期和細胞凋亡相關蛋白表達的影響； （ 3 ） axud1原核表達載體的構建及其在大腸桿菌中的表達。本實驗的主要結果和結論如下： 1利用一步法rt - pcr成功地從人類外周血淋巴細胞中克隆出axud1基因編碼區cdna ，並將其構建入真核表達載體中，編碼的ha - axud1融合蛋白帶有流感病毒凝血素ha的表位標記肽段。

Unfortunately, tumor cells can secrete immunosuppressor factors ( such as il - 10, tgf - p, vegf ) to interfere with dc maturation and function. to overcome tumor - mediated inhibition of dc maturation and function in vivo, immunopotentiating cytokines ( such as il - 7, il - 12 ) were used for gene - modification of dc, which has proven to be an efficient way to treat cancer in animal models

雖然有直接瘤內注射dc誘導抗腫瘤免疫效應的報道，但腫瘤局部往往是一個處于高度免疫抑制狀態的微環境，腫瘤細胞分泌的可溶性介質（如ill 、 tgf卜vegf等）能抑制dc的分化成熟，下調dc表面共刺激分子的表達和iliz的分泌，從而抑制dc的抗原提呈功能，亦對t細胞功能有顯著的抑制作用。

Besides morphologic changes, biological moecules including fgf10, integrin, egf, tgf play an important role in the process of eyelids ' reseperation

除了形態學上的變化外，表皮生長因子（ egf ） 、轉化生長因子（ tgf ） 、整合素等生物大分子也參與眼瞼的分離過程。

Experimental study on applying tgf - 1 gene transfection to modify in vivo tissue engineered cartilage

兔骨髓幹細胞向軟骨細胞分化用於半月板組織工程重建